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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
47 Results for "
brains
" in MedChemExpress (MCE) Product Catalog:
Products (47)
47 Results for "brains" in MCE Product Catalog:
11
11 Publications Verification
Cat. No.: HY-P0265A
Synonyms: Amyloid β-Peptide (1-40) (human) TFA; Aβ40 (human) TFA; Aβ(1-40) (human) TFA
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11
11 Publications Verification
Cat. No.: HY-P0265C
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2
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Mepyramine maleate (Pyrilamine maleate) is a selective histamine H1 receptor antagonist and KCNQ channel inhibitor, with an IC50 of 12.5 μM against KCNQ2/Q3. Mepyramine maleate shows no activity against allergic asthma in mice when used alone, but modulates the effect of JNJ 7777120 (HY-13508) on allergic asthma in mice; it inhibits the development of morphine physical dependence and increases histamine levels in mouse brains. Mepyramine maleate can be used in studies related to seizures, convulsions, allergic asthma and morphine physical dependence .
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2 Cited Publications
Synonyms: (S)-Cycloserine; (S)-4-Amino-3-isoxazolidone
Category:
Microorganisms Neurological Disease Antibiotics Disease Research Antibacterial Disease Research Fields Other Antibiotics Cancer
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GNE-8505 is an orally active, blood-brain barrier-permeable selective dual leucine zipper kinase (DLK) inhibitor. GNE-8505 has an IC50 of 0.144 μM for pJNK, and EC50 of 0.457 μM for DRG. GNE-8505 inhibits the DLK/JNK pathway, reduces stress-induced c-Jun phosphorylation levels, decreases neuronal death and suppresses axonal degeneration. GNE-8505 reduces phosphorylated c-Jun levels in the retina, spinal cord and brain tissues of mice. GNE-8505 is applicable to research related to Alzheimer's disease and amyotrophic lateral sclerosis (ALS) .
Cat. No.: HY-P1466
CAS No.: 131580-10-4
Synonyms: Amyloid β-Protein (1-16)
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Cat. No.: HY-P99185
CAS No.: 648895-38-9
Synonyms: AAB-001
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Synonyms: EKZ-001
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Bavarostat (EKZ-001) is a blood-brain barrier-permeable, potent HDAC6 inhibitor and PET radiotracer, with an IC50 as low as 17 nM against human HDAC6. Bavarostat can be labeled with 18F and used as a probe to map HDAC6 distribution and measure target occupancy in the brains of non-human primates. Bavarostat also selectively modulates tubulin acetylation, but not histone acetylation. Bavarostat is applicable for research on Alzheimer's disease, other neurodegenerative disorders, and cancers .
Cat. No.: HY-175748
CAS No.: 3056154-69-6
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MK-7337 is an α-synuclein ligand with an affinity of < 1 nM. MK-7337 labeled with 11C can be used as a PET tracer for neurodegenerative disorders like Parkinson’s disease imagination .
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Cat. No.: HY-101005
CAS No.: 16503-22-3
Synonyms: Nα-Methylhistamine dihydrochloride
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N-Methylhistamine dihydrochloride (Nα-Methylhistamine dihydrochloride) is a non-selective Histamine receptor agonist. N-Methylhistamine dihydrochloride activates histamine H1, H2 and H3 receptors; it stimulates central H1 receptors by activating sympathetic α and β adrenergic receptors to inhibit intestinal transit, exerts dose-dependent inhibition on intestinal transit, reduces histamine turnover in mouse brains, and increases gastric acid secretion without altering plasma gastrin concentrations. N-Methylhistamine dihydrochloride produces a pH-dependent, voltage-independent potentiating effect on acid-sensing ion channel 1a, and shows no significant activity toward homologous ASIC2a channels. N-Methylhistamine dihydrochloride can be used in studies related to Helicobacter pylori infection .
Cat. No.: HY-P1046
CAS No.: 183745-81-5
Synonyms: Amyloid β-Protein (1-15)
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Cat. No.: HY-126031
CAS No.: 2055172-60-4
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(R)-KT109 is a peripherally restricted serine hydrolase inhibitor that cannot cross the blood-brain barrier. (R)-KT109 irreversibly inhibits ABHD6, DAGLα and DAGLβ via carbamoylation of the active-site serine. (R)-KT109 exerts selective inhibitory effects on serine hydrolases in mouse brains, with pIC50 values of 8.6, 9.1 and 8.2 against human ABHD6, DAGLα and DAGLβ, respectively. (R)-KT109 effectively reduces the levels of 2-arachidonoylglycerol, arachidonic acid, eicosanoids and TNF-α. (R)-KT109 is widely used in studies of metabolic syndrome-related diseases and neuroinflammation .
Cat. No.: HY-P1468
CAS No.: 109770-29-8
Synonyms: Amyloid β-Protein (1-28)
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Cat. No.: HY-161246
CAS No.: 2323525-19-3
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uPSEM792 is a pharmacologically selective effector molecules (PSEM) agonist for PSAM 4-GlyR, with an affinity of Ki of 0.7 nM. uPSEM792 is a substrate for efflux transporters in brains of wild type and dual P-gp and BCRP knockout mice. uPSEM7952 is a possible lead for developing the PET radioligand for PSAM 4-GlyR .
Cat. No.: HY-P3780
CAS No.: 1802078-25-6
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Cat. No.: HY-P5754B
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Cat. No.: HY-W075176
CAS No.: 118712-89-3
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Transfluthrin is an insecticide with extremely low acute toxicity to vertebrates. Transfluthrin acts as a mosquito repellent, exerts mosquito control effects via electric heating fumigators, and is widely used in studies related to malaria, bancroftian filariasis and mosquito-borne infectious diseases. Transfluthrin may also induce adverse reactions such as pulmonary sensory irritation, sensitization, genotoxicity and respiratory depression, and can increase the concentrations and activities of CYP2E1 and CYP3A2 in rat brains. Transfluthrin can be removed from wastewater through biodegradation and activated sludge adsorption, and can be degraded by microorganisms such as Azovibrio and Tauera .
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MCAAD-3 is a near-infrared Aβ imaging probe with blood-brain barrier penetrability. MCAAD-3 has a strong affinity for Aβ polymers (Ki >106 nM) and can label Aβ plaques in the brains of transgenic mice .
Cat. No.: HY-P0265AS
Synonyms: Amyloid Beta-Peptide-15N (1-40) (human) TFA; Amyloid β-Peptide-15N (1-40) (human) TFA
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
