2. Neuronal Signaling
  3. Amyloid-β
  4. β-Amyloid (1-15)

β-Amyloid (1-15)  (Synonyms: Amyloid β-Protein (1-15))

Cat. No.: HY-P1046 Purity: 96.63%
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β-Amyloid (1-15) is a fragment of β-Amyloid peptide. Beta-amyloid is a peptide that forms amyloid plaques in the brains of Alzheimer's disease (AD) patients.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

β-Amyloid (1-15) Chemical Structure

β-Amyloid (1-15) Chemical Structure

CAS No. : 183745-81-5

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5 mg USD 125 In-stock
10 mg USD 200 In-stock
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Based on 1 publication(s) in Google Scholar

β-Amyloid (1-15) Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

β-Amyloid (1-15) is a fragment of β-Amyloid peptide. Beta-amyloid is a peptide that forms amyloid plaques in the brains of Alzheimer's disease (AD) patients.

IC50 & Target

Amyloid-β[1]
In Vitro

β-Amyloid (1-15) is produced by concerted β- and α-secretase cleavage of amyloid-β protein precursor (AβPP). β-Amyloid (1-15) seems to be a sensitive acute pharmacodynamic biomarker for γ-secretase inhibition and may have several advantages compared to measuring longer CSF Aβ species. [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

β-Amyloid (1-15) Related Antibodies
Molecular Weight

1826.84

Formula

C78H107N25O27
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln
Sequence Shortening

DAEFRHDSGYEVHHQ
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (27.37 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5474 mL 2.7370 mL 5.4739 mL
5 mM 0.1095 mL 0.5474 mL 1.0948 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.5474 mL 2.7370 mL 5.4739 mL 13.6848 mL
5 mM 0.1095 mL 0.5474 mL 1.0948 mL 2.7370 mL
10 mM 0.0547 mL 0.2737 mL 0.5474 mL 1.3685 mL
15 mM 0.0365 mL 0.1825 mL 0.3649 mL 0.9123 mL
20 mM 0.0274 mL 0.1368 mL 0.2737 mL 0.6842 mL
25 mM 0.0219 mL 0.1095 mL 0.2190 mL 0.5474 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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β-Amyloid (1-15) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Amyloid (1-15)183745-81-5Amyloid β-Protein (1-15)Amyloid-ββ-amyloid peptideAβAbetaInhibitorinhibitorinhibit

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