MK-7337
Based on 1 Customer Validation
MK-7337 is an α-synuclein ligand with an affinity of < 1 nM. MK-7337 labeled with 11C can be used as a PET tracer for neurodegenerative disorders like Parkinson’s disease imagination.
For research use only. We do not sell to patients.
- Purity: 98.14%
- CAS No.: 3056154-69-6
- Formula: C24H25N9O
- Molecular Weight:455.52
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
MK-7337 binds with high affinity (< 1 nM) to alpha-synuclein pathology in postmortem human PD, Alzheimer’s disease, and non-diseased brain tissues, with moderate off-target binding liability[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
[11C]MK-7337 exhibits favorable brain kinetic properties and a moderate risk of off-target binding in non-human primates without pathological conditions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3056154-69-6
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Appearance Solid
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Molecular Weight 455.52
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Formula C24H25N9O
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Color Off-white to light yellow
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SMILES
COC[C@H]1CN(CCN1C2=NC=CC=N2)C3=NC=C(C=N3)/C=C/C4=CC=C(N=C4)N5C=CN=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (265 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
- MK-7337
- 3056154-69-6
- MK7337
- MK 7337
- Radionuclide-Drug Conjugates (RDCs)
- α-synuclein
- postmortem non-diseased brain tissues
- postmortem human PD brain tissues
- alpha-synuclein pathology
- alpha-synuclein-overexpressing transgenic mouse midbrain/brainstem regions
- postmortem Alzheimer’s disease brain tissues
- non-human primate brains
- Parkinson's disease
- A30P transgenic mice
- Alzheimer’s disease
- postmortem Parkinson's disease brain tissues
- Inhibitor
- inhibitor
- inhibit