2. Antibody-drug Conjugate/ADC Related Neuronal Signaling
  3. Radionuclide-Drug Conjugates (RDCs) α-synuclein
  4. MK-7337

MK-7337 is an α-synuclein ligand with an affinity of < 1 nM. MK-7337 labeled with 11C can be used as a PET tracer for neurodegenerative disorders like Parkinson’s disease imagination.

For research use only. We do not sell to patients.

MK-7337

MK-7337 Chemical Structure

CAS No. : 3056154-69-6

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Based on 1 publication(s) in Google Scholar

MK-7337 Related Antibodies

Top Publications Citing Use of Products

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α-synuclein α-synuclein Aggregation α-synuclein/CHMP2B

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Description

MK-7337 is an α-synuclein ligand with an affinity of < 1 nM. MK-7337 labeled with 11C can be used as a PET tracer for neurodegenerative disorders like Parkinson’s disease imagination[1].

In Vitro

MK-7337 binds with high affinity (< 1 nM) to alpha-synuclein pathology in postmortem human PD, Alzheimer’s disease, and non-diseased brain tissues, with moderate off-target binding liability[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MK-7337 Related Antibodies
In Vivo

[11C]MK-7337 exhibits strongly displaceable binding to α-synuclein pathological structures in the brain/brainstem of aged A30P transgenic mice[1].
[11C]MK-7337 exhibits favorable brain kinetic properties and a moderate risk of off-target binding in non-human primates without pathological conditions[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

455.52

Formula

C24H25N9O
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

COC[C@H]1CN(CCN1C2=NC=CC=N2)C3=NC=C(C=N3)/C=C/C4=CC=C(N=C4)N5C=CN=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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MK-7337 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MK-73373056154-69-6MK7337MK 7337Radionuclide-Drug Conjugates (RDCs)α-synucleinα-Synpostmortem non-diseased brain tissuespostmortem human PD brain tissuesalpha-synuclein pathologyalpha-synuclein-overexpressing transgenic mouse midbrain/brainstem regionspostmortem Alzheimer’s disease brain tissuesnon-human primate brainsParkinson's diseaseA30P transgenic miceAlzheimer’s diseasepostmortem Parkinson's disease brain tissuesInhibitorinhibitorinhibit

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