16503-22-3
Chemical Structure
N-Methylhistamine dihydrochloride
Synonym(s): Nα-Methylhistamine dihydrochloride
- CAS No.: 16503-22-3
- Formula:C6H13Cl2N3
- Molecular Weight:198.09
IUPAC Name: 2-(1H-imidazol-5-yl)-N-methylethan-1-amine dihydrochloride
InChIKey: AYUQICXJAMPXPF-UHFFFAOYSA-N
SMILES: CNCCC1=CN=CN1.Cl.Cl
Biological Activity: N-Methylhistamine dihydrochloride (Nα-Methylhistamine dihydrochloride) is a non-selective Histamine receptor agonist. N-Methylhistamine dihydrochloride activates histamine H1, H2 and H3 receptors; it stimulates central H1 receptors by activating sympathetic α and β adrenergic receptors to inhibit intestinal transit, exerts dose-dependent inhibition on intestinal transit, reduces histamine turnover in mouse brains, and increases gastric acid secretion without altering plasma gastrin concentrations. N-Methylhistamine dihydrochloride produces a pH-dependent, voltage-independent potentiating effect on acid-sensing ion channel 1a, and shows no significant activity toward homologous ASIC2a channels. N-Methylhistamine dihydrochloride can be used in studies related to Helicobacter pylori infection[1][2][3][4].
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N-Methylhistamine dihydrochloride | 99.99% | N-Methylhistamine dihydrochloride (Nα-Methylhistamine dihydrochloride) is a non-selective Histamine receptor agonist. N-Methylhistamine dihydrochloride activates histamine H1, H2 and H3 receptors; it stimulates central H1 receptors by activating sympathetic α and β adrenergic receptors to inhibit intestinal transit, exerts dose-dependent inhibition on intestinal transit, reduces histamine turnover in mouse brains, and increases gastric acid secretion without altering plasma gastrin concentrations. N-Methylhistamine dihydrochloride produces a pH-dependent, voltage-independent potentiating effect on acid-sensing ion channel 1a, and shows no significant activity toward homologous ASIC2a channels. N-Methylhistamine dihydrochloride can be used in studies related to Helicobacter pylori infection. | ||||||||||||||||||||
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References
- [1]. Shteinikov VY, et al. Ligands of histamine receptors modulate acid-sensing ion channels. Biochemical and biophysical research communications. 2017 Sep 02;490(4):1314-1318. [Content Brief]
- [2]. Oishi R, et al. N alpha-methylhistamine inhibits intestinal transit in mice by central histamine H1 receptor activation. European journal of pharmacology. 1993 Jun 24;237(2-3):155-9. [Content Brief]
- [3]. Korte A, et al. Characterization and tissue distribution of H3 histamine receptors in guinea pigs by N alpha-methylhistamine. Biochemical and biophysical research communications. 1990 May 16;168(3):979-86. [Content Brief]
- [4]. Murray S, et al. N alpha-methylhistamine: association with Helicobacter pylori infection in humans and effects on gastric acid secretion. Clin Chim Acta. 2000 Nov;301(1-2):181-92. [Content Brief]
