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Results for "

catalytic oxidative cleavage

" in MedChemExpress (MCE) Product Catalog:

3

Inhibitors & Agonists

1

Fluorescent Dyes

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13817
    IU1
    20+ Cited Publications

    		 Deubiquitinase Autophagy Apoptosis Cardiovascular Disease Neurological Disease Endocrinology Cancer
    IU1 is a selective, reversible USP14 inhibitor with an IC50 of 4-5 μM. IU1 binds USP14’s catalytic cleft to block deubiquitinase activity. IU1 induces calpain-dependent Tau cleavage, causes ATP deficits, reduces E1~Ub thioester levels and 26S proteasome assembly. IU1 enhances 26S proteasome chymotrypsin-like activity, modulates LC3B-dependent autophagy flux, reduces cancer cell proliferation and migration, and blocks G0/G1 to S phase cell cycle transition in follicular thyroid cancer cells. IU1 activates autophagy-lysosomal and ubiquitin-proteasome pathways, triggers apoptosis, and reduces cervical cancer cell growth. IU1 enhances degradation of proteasome substrates linked to neurodegenerative disease, accelerates oxidized protein degradation, and increases oxidative stress resistance. IU1 can be used for the research of Alzheimer’s disease, follicular thyroid cancer, ischemic stroke, cervical cancer, and neurodegenerative disease .
    IU1
  • HY-W015301
    Dimethyl adipate

    Hexanedioic acid dimethyl ester

    		 Environmental Pollutants Drug Intermediate Others
    Dimethyl adipate (Hexanedioic acid dimethyl ester) is an aliphatic dicarboxylate compound. Dimethyl adipate is mainly used as a plasticizer and an intermediate in organic synthesis .
    Dimethyl adipate
  • HY-D3461
    CycLuc1 methyl ester

    		Carboxylesterase (CES) Fluorescent Dye Others
    CycLuc1 methyl ester (Example 1) is a selective CES1 substrate and indirect bioluminescent inducer. CycLuc1 methyl ester undergoes catalytic hydrolysis via CES1-mediated ester bond cleavage to form a carboxyl product. The carboxyl product of CycLuc1 methyl ester undergoes an oxidation reaction with luciferase to generate a detectable bioluminescent signal. CycLuc1 methyl ester enables quantitative detection of CES1 activity .
    CycLuc1 methyl ester

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