Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
chemical detection
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "chemical detection" in MCE Product Catalog:
3
3
3 Cited Publications
Cat. No.: HY-15922A
CAS No.: 20666-12-0
3
3 Cited Publications
Cat. No.: HY-K1099
MCE Endotoxin Detection Kit (Recombinant Factor C) is suitable for the detection of endotoxins in therapeutic injectable drugs for human use (such as chemical drugs, antibiotics, and biologics), as well as in medical devices including dialysis fluids and implantable devices. It can be applied throughout raw material screening, process development, manufacturing, and commercialization stages.
Cat. No.: HY-D0862
CAS No.: 145551-16-2
Cat. No.: HY-W133919
CAS No.: 28631-66-5
Cat. No.: HY-D2443
Cat. No.: HY-W004547
CAS No.: 18511-69-8
Synonyms: 4,4'-Diamino-2,2'-bipyridine
Cat. No.: HY-W200545
CAS No.: 4693-01-0
Target:
Research Areas:
1M6 is a reagent used for chemical detection of RNA structure .
Cat. No.: HY-D0898
CAS No.: 21872-70-8
Cat. No.: HY-D2475
CAS No.: 1359828-78-6
Cat. No.: HY-160043
Target:
Research Areas:
AL6 aptamer sodium is a short-chain nucleic acid aptamer chemically synthesized in vitro. AL6 aptamer sodium specifically targets Angiopoietin (Ang) for the specific detection of Ang. The AL6 aptamer binds to Ang, causing the rotational motion of the fluorophore on the AL6 aptamer to become slower. The concentration of Ang in the test solution can be quantified by detecting the anisotropy of AL6 aptamer/Ang .
Cat. No.: HY-D3581
Target:
Research Areas:
AF594 Picolyl Azide is a composite fluorescent probe formed by covalent linkage of the Alexa Fluor 594 fluorophore and the Picolyl Azide functional group via chemical bonds. AF594 Picolyl Azide contains a copper chelation domain, and through the copper-catalyzed azide-alkyne cycloaddition click chemistry reaction, it can covalently label alkyne-bearing target molecules and generate fluorescent detection signals. AF594 Picolyl Azide can be used for the detection of alkyne-modified sialylated glycoconjugates, and can also label nascent bacterial polypeptides to determine bacterial protein synthesis rates .
Cat. No.: HY-L152
5,064 compounds
19F-NMR has proved to be a detection mode in fragment-based drug discovery (FBDD) for studies of protein structure and interactions. 19F shows high sensitivity for NMR detection, and the exquisite sensitivity of 19F chemical shifts and linewidths to ligand binding all make it a valuable approach in FBDD.F (Fluorine) -Fragments can be used for 19F-NMR detection after binding to target proteins, and can be used as an effective 19F-NMR tool for FBDD.
MCE designs a unique collection of 5,064 F-fragments, all of which obey a heuristic rule called the “Rule of Three (RO3)”, in which molecular weight ≤300 Da, the number of hydrogen bond donors (H-donors) ≤3, the number of hydrogen bond acceptors (H-acceptors) is ≤3 and cLogP is ≤3. This F-fragments library is an important source of lead-like drugs.
Cat. No.: HY-D3170
Cat. No.: HY-W150770
CAS No.: 1740-57-4
Synonyms: Isophthalic acid diamide
Target:
Research Areas:
Isophthalamide (Isophthalic acid diamide) is a widely used chemical scaffold for the design of high-performance fluorescent chemosensors.Isophthalamide, with its inherent hydrogen-bond-donating properties and tunable chelating cavity, enables highly selective recognition and detection of various analytes ranging from inorganic ions to complex organic molecules.Isophthalamide can be incorporated with various fluorophores to develop sensors displaying “turn-on” or “turn-off” signal responses.Isophthalamide-based sensors are thus capable of detecting diverse analytes including metal ions, anions, neutral molecules, pharmaceuticals, and explosives .
Cat. No.: HY-D3109
CAS No.: 148043-22-5
Target:
Research Areas:
pH-Ap-1 is a fluorescent probe used for ratiometric monitoring of pH fluctuations during autophagy in living cells, and it can detect intracellular pH changes in the autophagy process. For fluorescence detection of pH-Ap-1, its excitation wavelength is 475 nm, with an emission wavelength of 538 nm under alkaline conditions and 645 nm under acidic conditions. For intracellular imaging, excitation is performed at 488 nm: the emission light ranging from 500-550 nm is collected via the green channel corresponding to 538 nm, while the emission light ranging from 625-750 nm is collected via the red channel corresponding to 645 nm. pH-Ap-1 exhibits excellent photostability and chemical stability .
Cat. No.: HY-184641
Aminated magnetic microspheres are superparamagnetic magnetic particles with amino functional groups modified on their surface, widely used in biomedical and molecular biology research. This 1μm aminated magnetic microsphere is composed of polystyrene and nano-iron oxide, exhibiting hydrophilicity and good biocompatibility. The aminated magnetic microspheres possess superparamagnetism, fast magnetic response, good monodispersity, ensuring reaction uniformity and detection consistency. The unique rough surface structure and polymer modification give the aminated magnetic microspheres a high amino density, allowing them to covalently couple with bioligands such as peptides, proteins, oligonucleotides, drug molecules, and glycoproteins through the action of special chemical reagents (such as glutaraldehyde). They serve as excellent coating materials and are important carrier tools in medical and biomolecular research.
Cat. No.: HY-LD002
100 billion compounds
The discovery of hit molecule is a cornerstone of drug development. Among the diverse tools available, DNA-encoded libraries have emerged a revolutionary platform for high-throughput screening. Compared with traditional HTS, DEL features shorter screening processes, lower costs, simpler assays, and larger library capacities.
DEL Construction utilizes split-and-pool synthesis, a combinatorial chemistry approach that involves iterative splitting, reaction, and pooling. This strategy enables rapid, exponential assembly of fragments in minimal steps without the need for individual compound synthesis andassoicicated isolation or purification steps, thus greatly reducing overall costs. The technology enables simultaneous affinity screeningof massive compound collections to target proteins in a single step. By coupling chemical structures with unique DNA barcodes, each compound is tagged with a distinct DNA sequence for convenient tracking and decoding.DELs readily enable the construction and efficient screening of libraries containing millions to billions of compounds. As a result, DEL screening combines the dual advantages of high efficiency and low cost, making DEL a transformative technology in modern drug discovery.
The DEL kit consists of 50 independent libraries with a total scale of 100 billion compounds. It is constructed through stepwise combinatorial chemistry strategies involving 2-, 3-, and 4-round synthesis. By employing diverse scaffolds and flexible linking strategies, it encompasses various ring systems, linear frameworks, and heterocyclic structures. Screening can be achieved solely through affinity, independent of target-specific activity detection methods. This library is suitable for DEL screening against a wide range of targets.
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
