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Results for "

cis-isomer

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (1) Apoptosis (1) Cholinesterase (ChE) (1) Constitutive Androstane Receptor (1) CXCR (1) Dipeptidyl Peptidase (1) DNA/RNA Synthesis (1) Drug Intermediate (1) Drug Isomer (11) Drug Metabolite (1) Endogenous Metabolite (3) Epigenetic Reader Domain (1) Estrogen Receptor/ERR (5) Gli (1) HCV (1) HDAC (2) Histone Methyltransferase (1) HIV (1) HSP (1) HSV (2) IGF-1R (1) Insulin Receptor (1) Interleukin Related (1) Isotope-Labeled Compounds (3) Phosphodiesterase (PDE) (1) Potassium Channel (1) Prostaglandin Receptor (1) PROTACs (1) Protein Arginine Deiminase (2) Reference Standards (1) Sodium Channel (1) Src (1) Tie (1) TNF Receptor (1) TRP Channel (2) TrxR (1) Tyrosinase (1) VEGFR (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (2) Endocrinology (7) Infection (4) Inflammation/Immunology (3) Metabolic Disease (8) Neurological Disease (5)

By Targets:

Acyltransferase (1)

Apoptosis (1)

Cholinesterase (ChE) (1)

Constitutive Androstane Receptor (1)

CXCR (1)

Dipeptidyl Peptidase (1)

DNA/RNA Synthesis (1)

Drug Intermediate (1)

Drug Isomer (11)

Drug Metabolite (1)

Endogenous Metabolite (3)

Epigenetic Reader Domain (1)

Estrogen Receptor/ERR (5)

Gli (1)

HCV (1)

HDAC (2)

Histone Methyltransferase (1)

HIV (1)

HSP (1)

HSV (2)

IGF-1R (1)

Insulin Receptor (1)

Interleukin Related (1)

Isotope-Labeled Compounds (3)

Phosphodiesterase (PDE) (1)

Potassium Channel (1)

Prostaglandin Receptor (1)

PROTACs (1)

Protein Arginine Deiminase (2)

Reference Standards (1)

Sodium Channel (1)

Src (1)

Tie (1)

TNF Receptor (1)

TRP Channel (2)

TrxR (1)

Tyrosinase (1)

VEGFR (1)

By Research Areas:

Cancer (6)

Cardiovascular Disease (2)

Endocrinology (7)

Infection (4)

Inflammation/Immunology (3)

Metabolic Disease (8)

Neurological Disease (5)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1583

(Z)-Capsaicin Zucapsaicin; Civamide; cis-Capsaicin	TRP Channel HSV	Neurological Disease
(Z)-Capsaicin is the cis isomer of capsaicin, acts as an orally active TRPV1 agonist, and is used in the research of neuropathic pain.

HY-107425A

cis-MZ 1	PROTACs Epigenetic Reader Domain	Cancer
cis-MZ 1 is a cis isomer of meso-zeaxanthin, a xanthophyll carotenoid component of total zeaxanthin measured in serum and egg yolks.cis-MZ 1 is a triphenyltin benzoate that adopts either a tetrahedral monomeric structure (I) or a trans-SnR₃O₂ polymeric structure (III), with structure determined by a balance of steric and electronic factors .

HY-B1617A

Zuclomiphene citrate 1 Publications Verification	Estrogen Receptor/ERR	Metabolic Disease Endocrinology
Zuclomiphene citrate is a cis isomer of Clomiphene citrate (HY-B0463). Zuclomiphene citrate is orally active and has an antiestrogenic effect. Zuclomiphene can reduce cholesterol levels. Zuclomiphene citrate can be for the researches of endocrinology and metabolic disease .

HY-N1952A

cis-Isoeugenol	Drug Isomer	Infection
cis-Isoeugenol is the cis isomer of Isoeugenol (HY-N1952) .

HY-B1342A

13-cis-Vitamin A 13-cis-Vitamin A1; 13-cis-Retinol	Drug Isomer Drug Metabolite	Metabolic Disease
13-cis-Vitamin A (13-cis-Vitamin A1) is the 13-cis-isomer of Vitamin A (HY-B1342), which is an active metabolite found in butter .

HY-182641

*SAG analog (cis-isomer)* SAG-Cl (cis-isomer)	Gli	Cardiovascular Disease
SAG analog (cis-isomer) (SAG-Cl (cis-isomer)) (Compound 10b) is a Gli1 activator with an EC₅₀ of 7.6 nM. SAG analog (cis-isomer) is non-toxic .

HY-114571

cis-Lomibuvir cis-VX-222	DNA/RNA Synthesis HCV	Infection
cis-Lomibuvir (cis-VX-222) is the cis-isomer of Lomibuvir. Lomibuvir (VX-222), a selective, non-nucleoside polymerase inhibitor, targets thumb pocket 2 of the HCV NS5B polymerase (RdRp) with a K_d of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC₅₀ of 5.2 nM. Lomibuvir preferentially inhibits elongative RNA synthesis rather than de novo-initiated RNA synthesis . cis-Lomibuvir is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W740803

15-cis-Phytofluene (15Z)-Phytofluene	Drug Intermediate Drug Isomer	Others
15-cis-Phytofluene is a cis-isomer of Phytofluene. 15-cis-Phytofluene is an acyclic carotenoid. 15-cis-Phytofluene acts as a biosynthetic intermediate in carotenoid biosynthesis .

HY-101648

ACAT-IN-1 cis isomer	Acyltransferase	Metabolic Disease
ACAT-IN-1 cis isomer is a potent ACAT inhibitor with an IC₅₀ of 100 nM.

HY-N8356A

9-cis-Vitamin A palmitate 9-cis-Retinyl palmitate	Endogenous Metabolite	Others
9-cis-Vitamin A palmitate (9-cis-Retinyl palmitate) is a 9-cis isomer formed by vitamin A palmitate in corn flakes. 9-cis-Vitamin A palmitate has a biological activity of 26% of all-trans-vitamin A palmitate, the most biologically ac-tive form of vitamin A .

HY-118105

RK-20448	Src VEGFR Tie	Infection Cancer
RK-20448 is an ATP-competitive inhibitor of Lck, Src, KDR/VEGF2R and Tie-2 with IC₅₀ values of 0.24, 1.19, 10.74 and 5.85 µM, respectively. RK-20448 also inhibits BLK, Csk, Fyn and Lyn with IC₅₀ values of 0.37, 4.27, 2.03 and 0.43 µM, respectively. RK-20448 is the cis isomer of A-419259 (HY-15764) .

HY-10252A

cis-NVP-ADW742 cis-ADW742; cis-GSK 552602A; cis-ADW	IGF-1R Insulin Receptor Apoptosis	Inflammation/Immunology
cis-NVP-ADW742 (cis-ADW742) is a cis isomer of NVP-ADW742 (HY-10252). NVP-ADW742 is an orally active, selective IGF-1R tyrosine kinase inhibitor with an IC₅₀ of 0.17 μM. NVP-ADW742 inhibits insulin receptor (InsR) with an IC₅₀ of 2.8 μM. NVP-ADW742 induces pleiotropic antiproliferative/proapoptotic biologic sequelae in tumor cells .

HY-15805A

cis-KIN-8194	Drug Isomer	Others
cis-KIN-8194 is the cis-isomer of KIN-8194 (HY-15805)

HY-161414

trans-VUF25471	CXCR	Others
trans-VUF25471 (Compound trans-3e) is a photoswitchable ACKR3 agonist. trans-VUF25471 binds and activates ACKR3 at 10-fold lower concentrations compared to its cis-isomer .

HY-119316A

CM-545	HDAC Phosphodiesterase (PDE)	Neurological Disease
CM-545, the cis-isomer of CM-414 (HY-119316), is a dual inhibitor of PDE5, HDAC1, HDAC2, HDAC3, and HDAC6 with pIC₅₀ values of 7.47, 6.65, 6.14, 6.55, and 6.84, repectively .

HY-171002

PAD2-IN-2	Protein Arginine Deiminase	Cancer
PAD2-IN-2 (cis-isomer of 1) is a protein arginine deiminase 2 (PAD2) inhibitor. PAD2-IN-2 possess an azobenzene photoswitch to optically control PAD activity. PAD2-IN-2 inhibits histone H3-citrullination .

HY-171002A

PAD2-IN-2 TFA	Protein Arginine Deiminase	Cancer
PAD2-IN-2 (cis-isomer of 1) TFA is a protein arginine deiminase 2 (PAD2) inhibitor. PAD2-IN-2 TFA possess an azobenzene photoswitch to optically control PAD activity. PAD2-IN-2 TFA inhibits histone H3-citrullination .

HY-173419

5-cis-15(R)-Iloprost 5-cis-15(R)-Ciloprost; 5-cis-15(R)-ZK 36374	Drug Isomer Prostaglandin Receptor	Endocrinology Cancer
5-cis-15(R)-Iloprost (5-cis-15(R)-Ciloprost) is the C-5 cis-isomer and 15(R)-epimer of Iloprost (HY-A0096). Iloprost is a prostacyclin (PGI2) analogue, involves in embryo development and inflammation improvement, and inhibits tumor metastasis. Iloprost can be used for peripheral vascular research .

HY-117583

cis-BG47	HDAC Histone Methyltransferase	Neurological Disease
cis-BG47 is an cis-isomer of BG47, BG47 is a prototypical histone deacetylases HDAC1 and HDAC2 selective, optoepigenetic probe. BG47 can bind to and competitively inhibits the deacetylase activity of HDAC targets upon a light-induced trans-to-cis isomerization, and increases Histone Methyltransferase H3K9 acetylation. cis-BG47 can be used for neurological disease research .

HY-155516A

cis-KV1.3-IN-1	Potassium Channel	Inflammation/Immunology
cis-KV1.3-IN-1 (Compound cis-18) is a cis-isomer of KV1.3-IN-1 (HY-155516). cis-KV1.3-IN-1 is an inhibitor of the KV1.3 channel. cis-KV1.3-IN-1 (10 μM) inhibits KV1.3 by 25.53% in Xenopus oocytes expressing human hKV1.3 .

HY-N0619A

cis-Mulberroside A Mulberroside D	TNF Receptor Interleukin Related Tyrosinase	Inflammation/Immunology
cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM .

HY-155295

Z-CITCO	Constitutive Androstane Receptor Drug Isomer	Metabolic Disease
Z-CITCO is the cis isomer of CITCO (HY-103244). Z-CITCO is an agonist of constitutive androstane receptor (CAR) with an EC₅₀ value of 3.9 µM .

HY-145806

13-cis-Retinyl acetate 13-cis-Retinol acetate; 13-cis-Vitamin A acetate	Endogenous Metabolite	Endocrinology
13-cis-Retinyl acetate (13-cis-Retinol acetate; 13-cis-Vitamin A acetate) is a 13-cis isomer formed by Retinyl acetate. 13-cis-Retinyl acetate is an active metabolite of vitamin A .

HY-B1583R

(Z)-Capsaicin (Standard) Zucapsaicin (Standard); Civamide (Standard); cis-Capsaicin (Standard)	Reference Standards TRP Channel HSV	Neurological Disease
(Z)-Capsaicin (Standard) is the analytical standard of (Z)-Capsaicin. This product is intended for research and analytical applications. (Z)-Capsaicin is the cis isomer of capsaicin, acts as an orally active TRPV1 agonist, and is used in the research of neuropathic pain.

HY-B1617

Zuclomiphene	Estrogen Receptor/ERR	Metabolic Disease Endocrinology
Zuclomiphene is a cis isomer of Clomiphene citrate (HY-B0463). Zuclomiphene is orally active and has an antiestrogenic effect. Zuclomiphene can reduce cholesterol levels. Zuclomiphene can be for the researches of endocrinology and metabolic disease .

HY-169234

BChE-IN-35	Cholinesterase (ChE)	Neurological Disease
BChE-IN-35 (Azo-9) is a BChE inhibitor. BChE-IN-35 has a dynamic cis/trans conformational change, where the cis isomer preferentially binds to BChE. BChE-IN-35 can be used in Alzheimer's disease (AD) research .

HY-N8356

13-cis-Vitamin A palmitate 13-cis-Retinyl palmitate	Endogenous Metabolite	Others
13-cis-Vitamin A palmitate (13-cis-Retinyl palmitate) is a 13-cis isomer formed by vitamin A palmitate in corn flakes. 13-cis-Vitamin A palmitate has a biological activity of 75% of all-trans-vitamin A palmitate, the most biologically ac-tive form of vitamin A .

HY-B1617AS2

Zuclomiphene d10 Citrate salt	Isotope-Labeled Compounds Estrogen Receptor/ERR	Metabolic Disease Endocrinology
Zuclomiphene d₁₀ Citrate salt is deuterium labeled Zuclomiphene citrate (HY-B1617A). Zuclomiphene citrate is a cis isomer of Clomiphene citrate (HY-B0463). Zuclomiphene citrate is orally active and has an antiestrogenic effect. Zuclomiphene can reduce cholesterol levels. Zuclomiphene citrate can be for the researches of endocrinology and metabolic disease .

HY-B1617AS

Zuclomiphene-d4 citrate	Isotope-Labeled Compounds Estrogen Receptor/ERR	Metabolic Disease Endocrinology
Zuclomiphene-d₄ citrate is a deuterium labeled Zuclomiphene citrate (HY-B1617A). Zuclomiphene citrate is a cis isomer of Clomiphene citrate (HY-B0463). Zuclomiphene citrate is orally active and has an antiestrogenic effect. Zuclomiphene can reduce cholesterol levels. Zuclomiphene citrate can be for the researches of endocrinology and metabolic disease .

HY-B1617AS1

Zuclomiphene-d5 citrate	Isotope-Labeled Compounds Estrogen Receptor/ERR	Metabolic Disease Endocrinology
Zuclomiphene-d₅ citrate is the deuterium labeled Zuclomiphene citrate (HY-B1617A). Zuclomiphene citrate is a cis isomer of Clomiphene citrate (HY-B0463). Zuclomiphene citrate is orally active and has an antiestrogenic effect. Zuclomiphene can reduce cholesterol levels. Zuclomiphene citrate can be for the researches of endocrinology and metabolic disease .

HY-N17724

Cimicifugic acid N	Drug Isomer	Others
Cimicifugic acid N is the cis-isomer of Cimicifugic acid G, can be found in the aerial parts of Cimicifuga simplex and Cimicifuga japonica .

HY-Z15805

Teprenone Impurity 5	Drug Isomer HSP TrxR	Cancer
Teprenone Impurity 5 (5Z-GGA) is the cis-isomer of Teprenone (HY-B0779). Teprenone Impurity 5 has inhibitory activity on the proliferation of human ovarian cancer cells Caov-3, and can block the invasion process of cancer cells. Teprenone Impurity 5 can induce the expression of heat shock protein 70 (HSP70) and thioredoxin (Trx). Teprenone Impurity 5 can be used for the research of ovarian cancer .

HY-141176B

cis-Cyclooctene-amine	Drug Isomer	Others
cis-Cyclooctene-amine is the cis isomer of TCO-amine (HY-141176). TCO-amine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. TCO-amine is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

HY-141176C

cis-Cyclooctene-amine hydrochloride	Drug Isomer	Others
cis-Cyclooctene-amine hydrochloride is the cis isomer of TCO-amine hydrochloride (HY-141176A). TCO-amine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. TCO-amine hydrochloride is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

HY-182334

azo-Q2a	Sodium Channel	Cardiovascular Disease
azo-Q2a is a photoswitchable Na_V1.5 inhibitor. azo-Q2a exists as the trans isomer with low activity in the dark or under 480 nm illumination, and exists as the cis isomer with higher inhibitory potency under 365 nm illumination. azo-Q2a reduces the heart rate of living zebrafish larvae in a light-dependent manner. azo-Q2a can be used for the study of arrhythmias .

HY-151871A

cis-ICeD-2	HIV Dipeptidyl Peptidase Drug Isomer	Infection
cis-ICeD-2 is the cis isomer of ICeD-2 (HY-151871). ICeD-2 is a cell death inducer that induces cell death in HIV-1-infected cells. ICeD-2-mediated killing of HIV-1-infected cells is dependent on HIV-1 protease activity. ICeD-2 effectively blocks the hydrolysis of Gly-Pro-AMC by the dipeptidyl peptidases DPP8 and DPP9. ICeD-2 demonstrates strong stability against DPP9 in PBMCs. .

Cat. No.	Product Name	Category	Target	Chemical Structure