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Results for "

collagen 3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Collagen (51) 11β-HSD (2) 5-HT Receptor (1) Acyltransferase (2) Adenosine Receptor (1) Adrenergic Receptor (4) Akt (7) Amine N-methyltransferase (1) Amino Acid Derivatives (4) Aminoacyl-tRNA Synthetase (1) AMPK (1) Amyloid-β (1) Anaplastic lymphoma kinase (ALK) (1) Angiotensin Receptor (5) Angiotensin-converting Enzyme (ACE) (4) Antibiotic (8) AP-1 (1) Apoptosis (55) Arginase (1) ATP Synthase (1) Autophagy (16) Bacterial (20) Bcl-2 Family (3) Bcr-Abl (1) Biochemical Assay Reagents (65) Btk (1) c-Fms (3) c-Kit (1) Cadherin (1) Calcium Channel (28) Cannabinoid Receptor (1) Carbonic Anhydrase (2) Caspase (9) CaSR (4) Cathepsin (6) CCR (2) CDK (1) Cholecystokinin Receptor (1) Cholinesterase (ChE) (4) Complement System (1) COX (7) CXCR (1) Cytochrome P450 (4) Discoidin Domain Receptor (9) DNA/RNA Synthesis (10) Dopamine β-hydroxylase (2) Drug Derivative (12) Drug Intermediate (6) Drug Isomer (1) Drug Metabolite (2) DYRK (2) EGFR (1) Endogenous Metabolite (43) Environmental Pollutants (5) ERK (10) Estrogen Receptor/ERR (1) Exosomes (1) Factor Xa (2) FAK (3) FAP (1) Ferroptosis (1) FGFR (1) FLT3 (2) Fluorescent Dye (4) Formyl Peptide Receptor (FPR) (1) Free Fatty Acid Receptor (1) Fungal (6) FXR (1) Galectin (3) Glutaminase (1) Glycoprotein VI (5) Glycosyltransferase (2) GPR55 (1) GSK-3 (2) Guanylate Cyclase (3) HDAC (6) Heme Oxygenase (HO) (1) HIF/HIF Prolyl-Hydroxylase (7) Histamine Receptor (1) Histone Methyltransferase (2) HIV (8) HIV Protease (2) HSP (1) HSV (2) IFNAR (3) Influenza Virus (1) Insecticide (1) Integrin (25) Interleukin Related (13) IRAK (5) Isotope-Labeled Compounds (5) JAK (6) JNK (8) Kallikrein (1) Keap1-Nrf2 (2) Leukotriene Receptor (1) Liposome (4) Lipoxygenase (4) LPL Receptor (3) LXR (1) Lysyl Oxidase (2) MDM-2/p53 (4) MHC (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (1) Mitophagy (1) MMP (66) MOFs (1) Molecular Glues (1) Monoamine Oxidase (7) mRNA (1) mTOR (5) Myosin (2) Na+/H+ Exchanger (NHE) (1) Necroptosis (1) Neprilysin (1) NF-κB (12) NO Synthase (9) NOD-like Receptor (NLR) (5) Notch (2) Osteopontin (2) P-glycoprotein (2) P-selectin (1) P2X Receptor (1) P2Y Receptor (3) p38 MAPK (14) PANoptosis (1) Parasite (9) PD-1/PD-L1 (1) PDGFR (1) PDI (1) PERK (1) PGC-1α (2) PGE synthase (4) Phosphatase (14) Phosphodiesterase (PDE) (11) Phospholipase (1) Photosensitizer (3) PI3K (6) Pim (1) PINK1/Parkin (1) PKA (6) PKC (7) PKG (1) Platelet-activating Factor Receptor (PAFR) (7) PPAR (5) Procollagen C Proteinase (1) Prostaglandin Receptor (8) PROTACs (1) Protease Activated Receptor (PAR) (3) Proteasome (8) Protein Arginine Deiminase (1) PTHR (1) Pyroptosis (1) RAR/RXR (1) Reactive Oxygen Species (ROS) (40) Reference Standards (38) ROCK (8) ROR (2) RUNX (1) RXFP Receptor (1) SARS-CoV (3) Sec61 (1) Serotonin Transporter (1) SGLT (1) Sialyltransferase (1) Sirtuin (2) SOD (3) Sodium Channel (8) Src (1) STAT (7) Syk (1) TAM Receptor (2) TGF-beta/Smad (28) TGF-β Receptor (12) Thrombin (4) Tie (1) TNF Receptor (14) Toll-like Receptor (TLR) (4) Transmembrane Glycoprotein (2) TREM receptor (3) Trk Receptor (1) TRP Channel (1) VD/VDR (2) VEGFR (4) VSV (1) Wnt (4) Xanthine Oxidase (1) α-synuclein (1) β-catenin (4)
By Research Areas:	Cancer (124) Cardiovascular Disease (109) Endocrinology (15) Infection (46) Inflammation/Immunology (262) Metabolic Disease (86) Neurological Disease (40)
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Targets Recommended: Collagen

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-NP003

Collagen, Type II, from bovine snout membrane 2 Publications Verification collagen	Collagen	Inflammation/Immunology
Collagen, Type II, from bovine snout membrane is a type II collagen that can be used for cell culture . This product is enzymatically hydrolyzed collagen peptides.

HY-P2738

Collagen, Type I, from bovine achilles tendon	MMP	Inflammation/Immunology
Collagen, Type I, from bovine achilles tendon are extracellular matrix proteins and show many applications in food, cosmetic, pharmaceutical and biomedical industries. This product is enzymatically hydrolyzed collagen peptide .

HY-NP010

*Type I Collagen, from rat tail*	MMP	Others
Collagen, rat tail is a kind of collagen extracted from rat tail tendon tissue. Collagen, rat tail stimulates cell growth. Collagen, rat tail is often used as an attachment substrate for cell culture ^[3].

HY-124817

Col003 5+ Cited Publications	HSP	Inflammation/Immunology
Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen binding site on Hsp47 (IC₅₀=1.8 μM). Col003 discourages the interaction of Hsp47 with collagen and inhibits collagen secretion by destabilizing the collagen triple helix. Col003 can be used for the investigation of fibrosis

HY-NP175

Collagen (bovine skin)	Biochemical Assay Reagents Integrin Discoidin Domain Receptor	Others
Collagen (bovine skin) is a three-dimensional cell culture matrix and morphoregulator extracted from bovine skin, which binds to integrins (such as α1β1, α2β1, α11β1) and discoidin domain receptors (DDR1 and DDR2). Collagen (bovine skin) can be reconstituted into a three-dimensional fibrous network to mimic the in vivo tissue environment. It can not only be modified through cross-linking or concentration adjustment, but also interact with fibronectin to enhance matrix-associated cellular activities. Collagen (bovine skin) mediates the proliferation, aggregation, durotactic migration and differentiation of fibroblasts, regulates the synthesis, remodeling and contraction of extracellular matrix, and modulates the expression, activation of MMP as well as cell apoptosis, etc. Collagen (bovine skin) can be used in studies related to the mechanisms of cancer occurrence and development .

HY-NP156

*Type I Collagen, for cell culture, from Bovine*	Biochemical Assay Reagents	Others
Type I Collagen, for cell culture, from Bovine plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, for cell culture, from Bovine can mimic the extracellular matrix (ECM) and is suitable for 2D/3D cell culture .

HY-29035

Dopamine acrylamide	Collagen	Others
Dopamine acrylamide, a polyphenol derivative, can cross-link collagen mainly via noncovalent bonding under acidic-non-oxidized conditions .

HY-15183

Collagen proline hydroxylase inhibitor	Collagen	Cancer
Collagen proline hydroxylase inhibitor is a collagen proline hydroxylase inhibitor, which can be used as an anti-fibrotic agent .

HY-NP132

*Recombinant Humanized Type III Collagen* 28.6kDa**	Biochemical Assay Reagents Integrin Autophagy Apoptosis Discoidin Domain Receptor	Cancer
Recombinant Humanized Type III Collagen 28.6kDa is a 28.6 kDa recombinant humanized type III collagen. Recombinant Humanized Type III Collagen possesses a variety of biological functions, such as promoting the regeneration of the skin extracellular matrix and improving the cellular microenvironment. Recombinant Humanized Type III Collagen can also inhibit the proliferation, migration and invasion of breast cancer cells. Recombinant Humanized Type III Collagen plays a role in cell adhesion, migration, proliferation and differentiation by interacting with Integrin .

HY-NP132A

*Recombinant humanized type III collagen* (MW 55900)**	Biochemical Assay Reagents Integrin Autophagy Apoptosis Discoidin Domain Receptor	Cancer
Recombinant humanized type III collagen (MW 55900) is a type III collagen with a molecular weight of 55900 Da. Recombinant humanized type III collagen has various biological functions, such as promoting skin extracellular matrix regeneration and improving the cell microenvironment. Recombinant humanized type III collagen inhibits the proliferation, migration, and invasion of breast cancer cells. Type III collagen functions in cell adhesion, migration, proliferation and differentiation through its interaction with integrins .

HY-P10904

Vezocolmitide ST-100	Collagen	Others
Vezocolmitide (ST-100) is a collagen mimetic peptide. Vezocolmitide can rapidly repair damaged collagen triple helix structures, thereby quickly reversing damage to the ocular surface and extracellular matrix, and restoring corneal nerve function while repairing the epithelium. Vezocolmitide can be used for research of dry eye disease (DED) .

HY-P5003

Collagen Type II Fragment	MMP	Inflammation/Immunology
Collagen Type II Fragment is an anti-inflammatory peptide that potently inhibits collagen-induced arthritis (CIA) in mice. Collagen Type II Fragment can be used for research on inflammation and immunity .

HY-NP160

Recombinant Humanized Type I Collagen 1 Publications Verification	Biochemical Assay Reagents	Others
Recombinant Humanized Type I Collagen is a recombinant humanized collagen protein with has unique immunological features and plays an important role in the structure and function of skin, bones, tendons, etc .

HY-P11087

P15	Collagen	Others
P15 is a collagen mimetic peptide with the sequence of GTPGPQGIAGQRGVV. P15 can mimic the cell-binding domain of human type I collagen. P15 is capable of promoting the adhesion, proliferation, and differentiation of osteoblasts. Biomaterials modified with P15 can be used in research related to bone regeneration .

HY-111247

Ro 09-0680	Others	Cardiovascular Disease
Ro 09-0680 is a potent inhibitor of rabbit platelet aggregation induced by Collagen with an IC₅₀ of 6.6 μM .

HY-W128156

10-Hydroxystearic acid 10-HSA	PPAR	Inflammation/Immunology
10-Hydroxystearic acid (10-HSA) is a PPARα agonist. 10-Hydroxystearic acid stimulates collagen synthesis. 10-Hydroxystearic acid is an anti-aging agent and reduces the appearance of pores and hyperpigmented lesions .

HY-P1868A

α2β1 Integrin Ligand Peptide TFA 3 Publications Verification DGEA peptide TFA	Integrin	Others
α2β1 Integrin Ligand Peptide TFA interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular signals into cells. It is a potential antagonist of collagen receptors .

HY-P2738A

Collagen petide Type I	MMP	Inflammation/Immunology
Type I collagen peptide is a fibrillar form of collagen that promotes the activation and growth of epithelial cells . This product is an enzymatically hydrolyzed collagen short peptide.

HY-NP109

*Highly purified type I collagen, from mouse skin* Mouse Type I collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified type I collagen, from mouse skin (Mouse Type I collagen, immunization grade) is an immune grade collagen derived from mouse skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP113

*Highly purified Type II collagen, from chick sternal cartilage* Chick Type II collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type II collagen, from chick sternal cartilage (Chick Type II collagen, immunization grade) is an immune grade collagen derived from chick sternal cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP101

*Highly purified Type I collagen, from bovine skin* 1 Publications Verification Bovine Type I collagen, immunization grade	Biochemical Assay Reagents	Inflammation/Immunology
Highly purified Type I collagen, from bovine skin (Bovine Type I collagen, immunization grade) plays an important role in the structure and function of skin, bone, tendons, and many others. Type I collagen potently stimulates angiogenesis in vitro and in vivo. Highly purified Type I collagen, from bovine skin is an immunization grade that can be used for immunization to generate antibodies .

HY-158225

Methacrylated Type I collagen Col1MA	MMP	Others
Methacrylated Type I collagen (Col1MA) is a methacrylated tissue engineering scaffold material that retains the basic properties of natural collagen . Methacrylated Type I collagen needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity. Application: cell culture, biological 3D printing, tissue engineering, etc.

HY-P3153

Cathepsin K 1 Publications Verification	Cathepsin	Metabolic Disease
Cathepsin K is a cysteine protease with endo and collagenolytic activities. Cathepsin K induces degradation of bone collagen and can be used for the research of osteoporosis .

HY-103070

PythiDC	MMP	Inflammation/Immunology
PythiDC is a selective collagen prolyl 4-hydroxylase (CP4H1) inhibitor with an IC₅₀ value of 4.0 μM. PythiDC can be used as a CP4H probe and also can be used for the development of a new class of antifibrotic and antimetastatic agents .

HY-146332

Collagen-IN-1	P-selectin	Cardiovascular Disease
Collagen-IN-1 (compound 3), an ortho-carbonyl hydroquinone derivative, is a selective inhibitor on *collagen. Collagen-IN-1 inhibits agonist-induced platelet aggregation in a non-competitive manner with an IC₅₀ value of 1.77 μM. Collagen-IN-1 reduces the expression of P-selectin, activation of glycoprotein IIb/IIIa, and release of adenosine triphosphate and CD63 from platelet. Collagen*-IN-1 has the potential for platelet-related thrombosis diseases research .

HY-NP126

*Highly purified Type XI collagen, from porcine articular cartilage* Porcine Type XI collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type XI collagen, from porcine articular cartilage (Porcine Type XI collagen, immunization grade) is an immune grade collagen derived from porcine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP162

Recombinant Humanized Type XVII Collagen	Biochemical Assay Reagents	Others
Recombinant Humanized Type XVII Collagen is a transmembrane protein that forms hemidesmosomes. Recombinant Humanized Type XVII Collagen facilitates interactions between stem cells，surrounding cells，and the extracellular matrix，thereby regulating skin homeostasis，aging，and wound healing. Recombinant Humanized Type XVII Collagen also possesses unique cell adhesion sites and signal transduction functions，which can regulate cell migration，proliferation，and differentiation .

HY-NP158A

*Type II Collagen, T Cell Grade, from Chick*	Biochemical Assay Reagents	Others
Type II Collagen, T Cell Grade, from Chick is a T-cell dependent antigen with unique immunological features. Type II Collagen, T Cell Chick, from Bovine can be used as a stimulating antigen for T-cells in in vitro culture systems .

HY-NP131

*Recombinant Humanized Type III Collagen* (10.4kDa)**	Discoidin Domain Receptor Apoptosis Autophagy	Cancer
Recombinant Humanized Type III Collagen 10.4kDa is a novel biomaterial that have anticancer effects. Recombinant Humanized Type III Collagen 10.4kDa activates discoidin domain receptor 1 (DDR1), and thus inhibits autophagy, proliferation, and migration of cancer cells, and induces apoptosis .

HY-113230B

Galactosylhydroxylysine hydrochloride 1 Publications Verification	Endogenous Metabolite	Metabolic Disease
Galactosylhydroxylysine hydrochloride is a component of bone collagen produced by post-translational glycosylation of hydroxylysine. Galactosylhydroxylysine hydrochloride is released during bone resorption and has been shown to be elevated in metabolic bone loss .

HY-NP102

*Highly purified Type II collagen, from bovine articular cartilage* Bovine Type II collagen, immunization grade	Biochemical Assay Reagents	Inflammation/Immunology
Highly purified Type II collagen, from bovine articular cartilage (Bovine Type II collagen, immunization grade), an immunization grade, is the major matrix protein in cartilage that can be used for the study of arthritis .

HY-NP103

*Highly purified Type III collagen, from bovine skin* Bovine Type III collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type III collagen, from bovine skin (Bovine Type III collagen, immunization grade) is an immune grade collagen derived from bovine skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-P2738B

Collagen petide Type II	MMP	Inflammation/Immunology
Collagen petide Type II is an extracellular matrix proteins and show many applications in food, cosmetic, pharmaceutical and biomedical industries. This product is enzymatically hydrolyzed collagen peptide .

HY-P1912

*Alpha 1(I) Collagen* (614-639), human**	MMP	Endocrinology
Alpha 1(I) Collagen (614-639), human is a peptide fragment of alpha-1 type I collagen.

HY-NP156A

*Type I Collagen, for cell culture, from Porcine*	Biochemical Assay Reagents	Others
Type I Collagen, for cell culture, from Porcine is a type of collagen derived from porcine sources, which can be used for cell culture .

HY-NP158

*Type II Collagen, T Cell Grade, from Bovine*	Biochemical Assay Reagents	Others
Type II Collagen, T Cell Grade, from Bovine is a T-cell dependent antigen with unique immunological features. Type II Collagen, T Cell Grade, from Bovine can be used as a stimulating antigen for T-cells in in vitro culture systems .

HY-NP157

*Type I Collagen, T Cell Grade, from Bovine*	Biochemical Assay Reagents	Others
Type I Collagen, T Cell Grade, from Bovine has unique immunological features and plays an important role in the structure and function of skin, bones, tendons, etc. Type I Collagen, T Cell Grade, from Bovine can be used as a stimulating antigen for T-cells in in vitro culture systems .

HY-145358

FAP-PI3KI1	PI3K	Cancer
FAP-PI3KI1 is a fibroblast-activated protein (FAP)-targeted *PI3K* inhibitor that selectively targets FAP-expressing human idiopathic pulmonary fibrosis (IPF) cells and effectively inhibits collagen synthesis and reduces collagen deposition .

HY-P0284A

C-telopeptide TFA	MMP	Inflammation/Immunology
C-telopeptide TFA, a cross-linked peptide of type I collagen, is released during bone resorption and has been correlated with bone mineral density (BMD) .

HY-113025A

L-hydroxylysine dihydrochloride (2S,5R)-5-Hydroxylysine dihydrochloride	Endogenous Metabolite	Others
L-hydroxylysine dihydrochloride ((2S,5R)-5-Hydroxylysine dihydrochloride), an amino acid, is exclusive to collagen protein, which is formed by posttranslational hydroxylation of some lysine residues .

HY-129502

Fibrostatin C P-23924C	HIF/HIF Prolyl-Hydroxylase	Others
Fibrostatin C (P-23924C) is an orally active prolyl hydroxylase inhibitor that also inhibits *collagen* biosynthesis. Fibrostatin C also increases the number of cytoplasmic granules immunoreactive with antibodies to collagen I or III. Fibrostatin C inhibits the secretion of type I collagen in Tenon's capsule fibroblasts. Fibrostatin C is promising for research of the wound fibrotic response in the wound of glaucoma filtering surgery .

HY-P990251

*Anti-Human/Mouse denatured collagen* type-I Antibody (XL313)**	MMP Collagen PD-1/PD-L1	Inflammation/Immunology Cancer
Anti-Human/Mouse denatured collagen type-I Antibody (XL313) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to human/mouse *denatured collagen* type-I*. Anti-Human/Mouse denatured collagen* type-I Antibody (XL313) selectively binds to proteolyzed collagen type I. Anti-Human/Mouse denatured collagen type-I Antibody (XL313) reduces PD L1 levels in tumor cells. Anti-Human/Mouse denatured collagen type-I Antibody (XL313) can be used for the researches of cancer and inflammation, such as such as ovarian tumor ^[3].

HY-NP124

*Highly purified Type III collagen, from porcine skin* Porcine Type III collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type III collagen, from porcine skin (Porcine Type III collagen, immunization grade) is an immune grade collagen derived from porcine skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP107

*Highly purified Type I collagen, from rat skin* Rat Type I collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type I collagen, from rat skin (Rat Type I collagen, immunization grade) is an immune grade collagen derived from rat skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP111

*Highly purified Type V collagen, from mouse intestine* Mouse Type V collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type V collagen, from mouse intestine (Mouse Type II collagen, immunization grade) is an immune grade collagen derived from mouse intestine, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP106

*Highly purified Type XI collagen, from bovine articular cartilage* Bovine Type XI collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type XI collagen, from bovine articular cartilage (Bovine Type XI collagen, immunization grade) is an immune grade collagen derived from bovine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP158I

Collagen Type II (undenatured)	Biochemical Assay Reagents	Inflammation/Immunology
Collagen Type II (undenatured) is a T-cell dependent antigen with unique immunological features. Type II Collagen, T Cell Grade, from Bovine can be used as a stimulating antigen for T-cells in in vitro culture systems .

HY-NP158D

*Type II Collagen, T Cell Grade, from Mouse*	Biochemical Assay Reagents	Others
Type II Collagen, T Cell Grade, from Mouse is a T-cell dependent antigen with unique immunological features. Type II Collagen, T Cell Grade, from Mouse can be used as a stimulating antigen for T-cells in in vitro culture systems .

HY-N12514

Cyclomulberrin	Others	Cardiovascular Disease
Cyclomulberrin is a extended flavonoid that shows inhibition of arachidonic acid (AA)- and collagen-induced platelet aggregation, with IC₅₀ value of 128.2 μM .

HY-P11447

COLIV-peptide	Collagen	Cardiovascular Disease
COLIV-peptide is a type of specific binding peptide that can recognize and bind to Collagen Ⅳ, a key non-cellular component in atherosclerotic plaques. COLIV-peptide can be used for the study of atherosclerotic .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0166

L-Ascorbic acid 75+ Cited Publications L-Ascorbate; Vitamin C	Structural Classification Natural Products Neurological Disease Classification of Application Fields Moringa oleifera Lam. Endocrine diseases Metabolic Disease Plants Endogenous metabolite Disease markers Moringaceae Nervous System Disorder Disease Research Fields Source Classification	Environmental Pollutants Endogenous Metabolite Calcium Channel Reactive Oxygen Species (ROS) Apoptosis
L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Ca_v3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor ^[3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .

HY-B0166A

L-Ascorbic acid sodium salt 75+ Cited Publications Sodium ascorbate; Sodium L-ascorbate; Vitamin C sodium salt	Structural Classification Natural Products other families Classification of Application Fields Plants Disease Research Fields Source Classification Cancer	Environmental Pollutants Apoptosis Endogenous Metabolite Calcium Channel Reactive Oxygen Species (ROS)
L-Ascorbic acid sodium salt (Sodium ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid sodium salt selectively inhibits Ca_v3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid sodium salt is also a collagen deposition enhancer and an elastogenesis inhibitor ^[3].

HY-103701A

L-Ascorbic acid 2-phosphate magnesium 5+ Cited Publications 2-Phospho-L-ascorbic acid magnesium; LAA2P magnesium	Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Phosphatase Reactive Oxygen Species (ROS) Endogenous Metabolite
L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) is a long-acting vitamin C derivative that can stimulate collagen formation and expression . L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation ^[3].

HY-107837

L-Ascorbic acid 2-phosphate trisodium 5+ Cited Publications 2-Phospho-L-ascorbic acid trisodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Phosphatase Reactive Oxygen Species (ROS) Endogenous Metabolite
L-Ascorbic acid 2-phosphate trisodium (2-Phospho-L-ascorbic acid trisodium) is a long-acting vitamin C derivative that can stimulate collagen formation and expression . L-Ascorbic acid 2-phosphate trisodium (2-Phospho-L-ascorbic acid trisodium) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-Ascorbic acid 2-phosphate trisodium (2-Phospho-L-ascorbic acid trisodium) increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation ^[3].

HY-N1584

Halofuginone 15+ Cited Publications RU-19110	Infection Cardiovascular Disease Alkaloids Piperidine Alkaloids Classification of Application Fields Dichroa febrifuga Lour Saxifragaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM . Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity ^[3] . Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca ²⁺ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-P3160

Fibronectin Maximum Cited Publications 8 Publications Verification	Cardiovascular Disease Structural Classification Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Integrin
Fibronectin, a glycoprotein present in blood as well as in cells, is a biomarker of tissue injury. Fibronectin binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans . This product is a human Fibronectin obtained by recombinant expression in a rice expression system.

HY-103701

L-Ascorbic acid 2-phosphate 5+ Cited Publications 2-Phospho-L-ascorbic acid; LAA2P	Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Phosphatase Reactive Oxygen Species (ROS) Endogenous Metabolite
L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) is a long-acting vitamin C derivative that can stimulate collagen formation and expression . L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-ascorbic acid 2-phosphate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation ^[3].

HY-103701B

L-Ascorbic acid 2-phosphate magnesium hydrate 5+ Cited Publications 2-Phospho-L-ascorbic acid magnesium hydrate; LAA2P magnesium hydrate	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Phosphatase Reactive Oxygen Species (ROS) Endogenous Metabolite
L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) magnesium hydrate is a long-acting vitamin C derivative that can stimulate collagen formation and expression. L-ascorbic acid 2-phosphate magnesium hydrate can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-ascorbic acid 2-phosphate magnesium hydrate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation ^[3].

HY-P0063

Copper tripeptide 1 Publications Verification GHK-Cu	Natural Products Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Biochemical Assay Reagents
Copper tripeptide (GHK-Cu) is a tripeptide. During wound healing, Copper tripeptide may be freed from existing extracellular proteins via proteolysis and serves as a chemoattractant for inflammatory and endothelial cells. Copper tripeptide has been shown to increase messenger RNA production for collagen, elastin, proteoglycans, and glycosaminoglycans in fibroblasts. Copper tripeptide is a natural modulator of multiple cllular pathways in skin regeneration .

HY-119358

Traumatic Acid 3 Publications Verification	Microorganisms Classification of Application Fields Leguminosae Ketones, Aldehydes, Acids Plants Phytohormone Phaseolus vulgaris Linn. Inflammation/Immunology Disease Research Fields Cytokinin Source Classification Agricultural Research	Reactive Oxygen Species (ROS) Apoptosis
Traumatic Acid is a wound healing agent and a cytokinin (phytohormone). Traumatic Acid enhances the biosynthesis of collagen in cultured human skin fibroblasts. Traumatic Acid inhibits MCF-7 breast cancer cells viability and enhances apoptosis and oxidative stress. Traumatic Acid can be used in studies of cancer, circulatory disorders (including arterial hypertension), and skin diseases associated with oxidative stress and impaired collagen biosynthesis .

HY-17367

Atazanavir 10+ Cited Publications BMS-232632	Infection Structural Classification Alkaloids Classification of Application Fields Pyridine Alkaloids Endogenous metabolite Disease Research Fields Source Classification Cancer	HIV HIV Protease SARS-CoV Cytochrome P450 P-glycoprotein Endogenous Metabolite Toll-like Receptor (TLR)
Atazanavir (BMS-232632) is a highly selective and orally active HIV-1 protease inhibitor . Atazanavir is a substrate and inhibitor of *CYP3A4, and an inhibitor of P-glycoprotein (P-gp). Atazanavir is also a SARS-CoV 3CL ^pro* inhibitor with an IC₅₀ of 3.49 μM. Atazanavir inhibits cardiac fibrosis, hyperlipidemia and induces malignant glioma death ^[3] .

HY-B0166R

L-Ascorbic acid (Standard) 2 Publications Verification L-Ascorbate (Standard); Vitamin C (Standard)	Structural Classification Natural Products Microorganisms Moringa oleifera Lam. Disease markers Endocrine diseases Moringaceae Nervous System Disorder Plants Endogenous metabolite Source Classification	Reference Standards Reactive Oxygen Species (ROS) Calcium Channel Apoptosis Endogenous Metabolite
L-Ascorbic acid (Standard) is the analytical standard of L-Ascorbic acid. This product is intended for research and analytical applications. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Ca_v3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor ^[3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .

HY-N1584A

Halofuginone hydrobromide 15+ Cited Publications RU-19110 hydrobromide	Infection Cardiovascular Disease Alkaloids Piperidine Alkaloids Classification of Application Fields Dichroa febrifuga Lour Saxifragaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM . Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity ^[3] . Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca ²⁺ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-W016887

Glycyl-L-proline H-Gly-Pro-OH; Gly-Pro	Alkaloids Structural Classification Human Gut Microbiota Metabolites Pyrrole Alkaloids Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Apoptosis
Glycyl-L-proline (H-Gly-Pro-OH) is a dipeptide. Glycyl-L-proline can induce MCF-7 cells apoptosis. Glycyl-L-proline can enhance the inhibitory effect of the PRODH/POX knockout on collagen and DNA biosynthesis. Glycyl-L-proline can inhibit Gly-Sar and L-proline transport. Glycyl-L-proline can be used for the researches of cancer and metabolic disease, such as breast cancer ^[3].

HY-B0987

Ascorbyl palmitate 3 Publications Verification L-Ascorbic acid 6-hexadecanoate; 6-O-Palmitoyl-L-ascorbic acid	Structural Classification Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Environmental Pollutants Reactive Oxygen Species (ROS) Endogenous Metabolite Apoptosis Bcl-2 Family Caspase Calcium Channel NOD-like Receptor (NLR) Sodium Channel
Ascorbyl palmitate is an orally active ester formed from ascorbic acid and palmitic acid, used as an antioxidant and food additive. Ascorbyl palmitate in preventing fat and oil oxidation is more efficient than Butylated hydroxyanisole (HY-B1066) and Butylated hydroxytoluene (HY-Y0172). Ascorbyl palmitate mitigates inhibition of collagen synthesis by select calcium and sodium channel blockers. Ascorbyl palmitate induces Apoptosis in human umbilical vein endothelial cells (HUVECs). Ascorbyl palmitate ameliorates inflammatory diseases by inhibition of *NLRP3* inflammasome ^[3] .

HY-W016409

Ethyl 3,4-dihydroxybenzoate 1 Publications Verification Protocatechuic acid ethyl ester	Arachis hypogaea L. Classification of Application Fields Leguminosae Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Source Classification	HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) NO Synthase Autophagy Apoptosis
Ethyl 3,4-dihydroxybenzoate (Protocatechuic acid ethyl ester) is an orally effective, blood-brain barrier-permeable, competitive prolyl hydroxylase (PHD) inhibitor that inhibits the hydroxylation modification of hypoxia-inducible factor (HIF) by PHD. Ethyl 3,4-dihydroxybenzoate stabilizes HIF-1α by inhibiting PHD, activates downstream pathways to induce autophagy and apoptosis of tumor cells, and regulates inflammatory responses, inhibits the NF-κB pathway, improves vascular permeability, and promotes osteoblast differentiation. Ethyl 3,4-dihydroxybenzoate has anti-tumor, anti-hypoxic injury, and bone metabolism regulation effects. It can also be used in the research of cardiovascular protection (such as reducing myocardial ischemic damage), bone tissue engineering (promoting osteogenesis/inhibiting osteoclast differentiation), and prevention and treatment of high-altitude cerebral edema ^[3] .

HY-N0331

Ziyuglycoside I 1 Publications Verification	Triterpenes Classification of Application Fields Sanguisorba officinalis Linn. Terpenoids Rosaceae Plants Disease Research Fields Source Classification Cancer	MDM-2/p53 Apoptosis
Ziyuglycoside I isolated from S. officinalis root, has anti-wrinkle activity, and increases the expression of type I collagen. Ziyuglycoside I could be used as an active ingredient for cosmetics . Ziyuglycoside I triggers cell cycle arrest and apoptosis mediated by p53, it can be a potential agent candidate for treating triple-negative breast cancer (TNBC) .

HY-17367A

Atazanavir sulfate 10+ Cited Publications BMS-232632 sulfate	Infection Structural Classification Alkaloids Classification of Application Fields Pyridine Alkaloids Endogenous metabolite Disease Research Fields Source Classification Cancer	HIV HIV Protease SARS-CoV Cytochrome P450 P-glycoprotein Endogenous Metabolite Toll-like Receptor (TLR)
Atazanavir (BMS-232632) sulfate is a highly selective and orally active HIV-1 protease inhibitor with blood-brain barrier permeability. Atazanavir sulfate is a substrate and inhibitor of *CYP3A4, and an inhibitor of P-glycoprotein (P-gp). Atazanavir sulfate is also a SARS-CoV 3CL ^pro* inhibitor with an IC₅₀ of 3.49 μM. Atazanavir sulfate inhibits cardiac fibrosis, hyperlipidemia and induces malignant glioma death ^[3] .

HY-N1887

4-Allylcatechol 1 Publications Verification Hydroxychavicol; 4-Allylpyrocatechol	Ophiopogon japonicus (L. f.) Ker-Gawl. Liliaceae Classification of Application Fields Other Diseases Phenols Polyphenols Plants Disease Research Fields Source Classification	Bacterial Antibiotic TNF Receptor Interleukin Related
4-Allylcatechol (4-Allylpyrocatechol) is a xylan which has oral activity and can be isolated from the root of Piper taiwanense. 4-Allylcatechol has a strong inhibitory activity against collagen-induced platelet aggregation (IC₅₀ = 5.3 μM). In addition, 4-Allylcatechol has anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv (MIC = 27.6 μg/mL) .

HY-D0835

Hydroxylapatite (25-45 μm) Hydroxyapatite (25-45 μm)	Natural Products Animals Classification of Application Fields Other Diseases Disease Research Fields Source Classification	Others
Hydroxylapatite (Hydroxyapatite) (25-45 μm) is a natural form of calcium phosphate and is the main mineral component of bones and teeth. Hydroxylapatite (25-45 μm) can stimulate the expression and secretion of collagen in primary human dermal fibroblasts. Hydroxylapatite (25-45 μm) has good biocompatibility, bioactivity, and bone conductivity, making it suitable for targeted drug or nucleic acid delivery. Hydroxylapatite (25-45 μm) can be used in research on osteoarthritis, gout, and atherosclerosis .

HY-114495

Caerulomycin A 3 Publications Verification Cerulomycin; Caerulomycin	Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Classification of Application Fields Antibiotics Antibacterial Disease Research Anticancer Inflammation/Immunology Disease Research Fields Other Antibiotics Source Classification	Fungal Antibiotic
Caerulomycin A is an orally active immunomodulator and antimicrobial agent. Caerulomycin A targets *Smad3, STAT1* and *GATA-3. Caerulomycin A downregulates GATA-3* expression, inhibits Th2 cell differentiation and Th2 cytokine production, reduces IgE levels, and alleviates pulmonary inflammatory responses and eosinophil infiltration. Caerulomycin A ameliorates collagen-induced arthritis symptoms, reduces joint inflammation and synovitis, and decreases the levels of proinflammatory cytokines in joints. Caerulomycin A inhibits the growth of some filamentous fungi, yeasts and specific bacteria. Caerulomycin A can be used in research related to arthritis and asthma ^[3].

HY-40136

cis-4-Hydroxy-L-proline	Microorganisms Classification of Application Fields Santalum album Linn. Ketones, Aldehydes, Acids Metabolic Disease Plants Endogenous metabolite Disease Research Fields Source Classification Santalaceae	Endogenous Metabolite
cis-4-Hydroxy-L-proline is an orally active proline analog and collagen production inhibitor. cis-4-Hydroxy-L-proline inhibits cell growth by preventing the deposition of triple helical collagen on the cell layer. cis-4-Hydroxy-L-proline inhibits N-nitrosomethylurea-induced breast tumor growth. cis-4-Hydroxy-L-proline improves lung compliance and reduces prostate weight. cis-4-Hydroxy-L-proline can be used in the study of hypoxic pulmonary hypertension ^[3] .

HY-N12408

Globotriaosylsphingosine Lyso-Gb3; Lyso-GL3	Structural Classification Animals Lipid Source Classification	Calcium Channel
Globotriaosylsphingosine (Lyso-Gb3) inhibits the growth of fibroblasts, as well as their differentiation into myofibroblasts, and collagen expression. Globotriaosylsphingosine can be used for Fabry disease research .

HY-W014930

DL-5-Hydroxylysine hydrochloride	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
DL-5-Hydroxylysine hydrochloride is a non-essential amino acid that is mainly found in collagen. DL-5-Hydroxylysine hydrochloride is a post-translational modified form of lysine .

HY-N2163

Mudanpioside C	Structural Classification Other Monoterpenes Monophenols other families Classification of Application Fields Terpenoids Other Diseases Phenols Plants Disease Research Fields Source Classification	PDI
Mudanpioside C is a protein disulfide isomerase (PDI) inhibitor with a human IC₅₀ of 3.31 μM and human K_d of 3.9 μM. Mudanpioside C suppresses collagen-induced platelet aggregation, interferes with platelet activation, adhesion, and spreading. Mudanpioside C can be used for the research of cardiovascular diseases .

HY-N0912

Rehmannioside D 1 Publications Verification	Structural Classification Iridoids Classification of Application Fields Terpenoids Other Diseases Scrophulariaceae Plants Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey Disease Research Fields Source Classification	Sirtuin Apoptosis MDM-2/p53 Reactive Oxygen Species (ROS) Bcl-2 Family Caspase
Rehmannioside D is an orally active Sirt7 modulator. Rehmannioside D upregulates Sirt7 expression, inhibits the level of acetylated p53, and blocks the activation of the p53 signaling pathway. Rehmannioside D alleviates liver injury, inflammatory response, collagen deposition and hepatocyte apoptosis. Rehmannioside D is applicable to research related to liver fibrosis .

HY-N6857

Armepavine	Structural Classification Classification of Application Fields Plants Nymphaeaceae Alkaloids Monophenols other families Phenols Nelumbo nucifera Gaertn. Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Source Classification	AP-1 NF-κB p38 MAPK ERK JNK
Armepavine, found in Nelumbo nucifera, is an orally active NF-κB inhibitor. Armepavine attenuates expression of p-p65, α-SMA, p-JNK1/2, p-ERK1/2, p-p38α stimulated by TNF-α and LPS. Armepavine suppresses NF-κB nuclear translocation, IκBα phosphorylation, and collagen deposition. Armepavine can be used for the research of hepatic fibrosis and leukemia .

HY-N7400

Phaseoloidin	Structural Classification Monophenols other families Classification of Application Fields Other Diseases Phenols Plants Disease Research Fields Source Classification	NOD-like Receptor (NLR) Caspase Insecticide
Phaseoloidin is an orally active multi-target inhibitor. Phaseoloidin inhibits the activation of the *NLRP3* inflammasome and blocks the caspase-11-GSDMD pyroptosis axis. Phaseoloidin reduces the expression of collagen-degrading enzymes to maintain the integrity of cartilage matrix. Phaseoloidin activates the AMPK/mTOR pathway to enhance autophagic function. Phaseoloidin exerts adverse effects on the growth and development of Manduca sexta and Spodoptera littoralis larvae, inhibits larval growth, and thereby helps Nicotiana attenuata defend against lepidopteran herbivorous insects. Phaseoloidin is applicable to research related to acute gouty arthritis and pulmonary fibrosis ^[3].

HY-126956

Porphyra 334	Structural Classification Animals Classification of Application Fields Sunscreen Ketones, Aldehydes, Acids Metabolic Disease Amino acids Cosmetic Research Disease Research Fields Source Classification	Reactive Oxygen Species (ROS) MMP Collagen PPAR DNA/RNA Synthesis Apoptosis Caspase
Porphyra 334 is a carnosine-like amino acid and a natural photoprotective agent and antioxidant. Porphyra-334 exerts its photoprotective effects by scavenging ROS, inhibiting the expression and activity of MMP-1/8, and promoting the synthesis of *collagen* and elastin. Porphyra 334 effectively inhibits linoleic acid oxidation induced by alkyl radicals (AAPH) and singlet oxygen. Porphyra 334 has anti-obesity potential by inhibiting the expression of PPARγ2 and C/EBPα. Porphyra 334 protects cells against UV-induced DNA damage and apoptosis by inhibiting the activation of *caspase-3* ^[3] .

HY-134216

MAHMA NONOate 1 Publications Verification	Cardiovascular Disease Alkaloids Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite NO Synthase
MAHMA NONOate is a NO donor. MAHMA NONOate effectively inhibits platelet aggregation induced by either collagen or ADP .

HY-134636

PAPA NONOate 2 Publications Verification	Alkaloids Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Endogenous Metabolite
PAPA NONOate is a NO donor with a NO release half-life of 77 min (22-25°C). PAPA NONOate may represent a potential research for impaired wound healing in diabetes by increasing the rate of collagen synthesis at the wound site ^[3].

HY-N2589

Isosaponarin	Flavonoids Vaccaria segetalis (Neck.) Garcke Classification of Application Fields Flavones Other Diseases Phenols Polyphenols Plants Disease Research Fields Caryophyllaceae Source Classification	TGF-β Receptor Collagen
Isosaponarin is a flavone glycoside isolated from wasabi leaves. Isosaponarin is a P4HA2 enzymatic agonist. Isosaponarin increases *collagen* synthesis via up-regulated TGF-β type II receptor (TβR-II) and prolyl 4-hydroxylase (P4H) proteins production, promoting skin health and wound healing. Isosaponarin-rich plants exhibit strong antimicrobial, antioxidant, anti-hyaluronidase, antiplatelet, anti-atopic dermatitis, and anti-tumor effects ^[3] .

HY-N7619

Xanthopurpurin Purpuroxanthin	Quinones other families Classification of Application Fields Anthraquinones Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Source Classification	HIV
Xanthopurpurin is an orally active anthraquinone glycoside. Xanthopurpurin can be isolated from the rhizome of Rubia akane. Xanthopurpurin has antiviral effects against rotavirus and HIV. Xanthopurpurin has a strong inhibitory effect on collagen-induced platelet aggregation. Xanthopurpurin prevents peanut allergy ^[3] .

HY-N0363

(+)-Columbianetin 2 Publications Verification (S)-Columbianetin	Structural Classification Classification of Application Fields Coumarins Phenylpropanoids Umbelliferae Plants Seriphidium transiliense Inflammation/Immunology Disease Research Fields Source Classification	ERK JNK Collagen TGF-beta/Smad p38 MAPK Reactive Oxygen Species (ROS)
(+)-Columbianetin ((S)-Columbianetin) acts as an inhibitor of JNK/ERK. (+)-Columbianetin inhibits UVA-induced phosphorylation of JNK and ERK, reduces the production of MMP-1, reverses UVA-induced Collagen (HY-NP003) degradation, and alleviates UVA-mediated inhibition of *Smad2/3* phosphorylation and translocation. (+)-Columbianetin regulates the AP-1 and ASK1-MAPK signaling pathways, inhibits the production of ROS and blocks sub-G₁ cell cycle arrest. (+)-Columbianetin is applicable to research related to skin aging .

HY-N4119

Neoeriocitrin	Structural Classification Flavonoids other families Flavonones Phenols Polyphenols Plants Source Classification	Phosphatase Cholinesterase (ChE) p38 MAPK Apoptosis Autophagy
Neoeriocitrin is a Naringin (HY-N0153) analogue found in Drynaria Rhizome. Neoeriocitrin induces cells proliferation, differentiation, up-regulates type I collagen, osteocalcin, and key osteogenic markers, and increases ALP activity. Neoeriocitrin increases expression of Runx2, COL I, OCN and Beclin1. Neoeriocitrin inhibits phosphorylation of P38 mitogen-activated protein kinase, reduces acetylcholinesterase (AChE) activity, and increases choline acetyltransferase (ChAT) activity. Neoeriocitrin reduces apoptosis and induces autophagy. Neoeriocitrin can be used for the researches of osteoporosis and Alzheimer's disease ^[3] .

HY-111247

Ro 09-0680	Ketones, Aldehydes, Acids Labiatae Samanea saman (Jacq.) Merr. Plants Source Classification	Others
Ro 09-0680 is a potent inhibitor of rabbit platelet aggregation induced by Collagen with an IC₅₀ of 6.6 μM .

HY-113033

Pentosidine	Structural Classification Natural Products Disease markers Endogenous metabolite Source Classification	Others Biochemical Assay Reagents
Pentosidine is a fluorescent advanced glycation end product (AGE) and cross-linker. Pentosidine is a fluorescent cross-linked structure formed by lysine and arginine in sugar oxidation reactions, and it is commonly found in collagen, skin, bone, lens and plasma proteins . Pentosidine is used in research related to type 1 diabetes, brown cataracts, rheumatoid arthritis, atherosclerosis and neurodegenerative diseases .

HY-N2503

Ginsenoside F4	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Plants Inflammation/Immunology Disease Research Fields Araliaceae Source Classification	Apoptosis MMP
Ginsenoside F4 (GF4), ginseng saponinis, isolated from notoginseng or red ginseng. Ginsenoside F4 (GF4) has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis . Ginsenoside F4 (GF4) inhibits matrix metalloproteinase 13 (MMP 13) expression in IL-1β-treated chondrocytes and blocks cartilage breakdown in rabbit cartilage tissue culture, shows therapeutic potential for preventing cartilage collagen matrix breakdown in diseased tissues .

HY-N9794

Isoboldine	Alkaloids Piperidine Alkaloids Phenols Polyphenols Plants Lauraceae Lindera aggregata (Sims) Kosterm. Source Classification	Others
Isoboldine is a pyridine alkaloid. Isoboldine effectively alleviates inflammation and joint destruction in collagen-induced arthritis in mice .

HY-W016887R

Glycyl-L-proline (Standard) H-Gly-Pro-OH (Standard); Gly-Pro (Standard)	Alkaloids Structural Classification Human Gut Microbiota Metabolites Microorganisms Pyrrole Alkaloids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
H-Gly-Pro-OH (Standard) is the analytical standard of H-Gly-Pro-OH. This product is intended for research and analytical applications. H-Gly-Pro-OH is an end product of collagen metabolism that is further cleaved by prolidase.

HY-113230B

Galactosylhydroxylysine hydrochloride 1 Publications Verification	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Galactosylhydroxylysine hydrochloride is a component of bone collagen produced by post-translational glycosylation of hydroxylysine. Galactosylhydroxylysine hydrochloride is released during bone resorption and has been shown to be elevated in metabolic bone loss .

HY-119358R

Traumatic Acid (Standard)	Structural Classification Microorganisms Leguminosae Ketones, Aldehydes, Acids Plants Phaseolus vulgaris Linn. Source Classification	Reference Standards Reactive Oxygen Species (ROS) Apoptosis
Traumatic Acid (Standard) is the analytical standard of Traumatic Acid. This product is intended for research and analytical applications. Traumatic Acid is a wound healing agent and a cytokinin (phytohormone). Traumatic Acid enhances the biosynthesis of collagen in cultured human skin fibroblasts. Traumatic Acid inhibits MCF-7 breast cancer cells viability and enhances apoptosis and oxidative stress. Traumatic Acid can be used in studies of cancer, circulatory disorders (including arterial hypertension), and skin diseases associated with oxidative stress and impaired collagen biosynthesis[1][2].

HY-N1584R

Halofuginone (Standard) RU-19110 (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Dichroa febrifuga Lour Saxifragaceae Plants Source Classification	Reference Standards DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (Standard) is the analytical standard of Halofuginone. This product is intended for research and analytical applications. Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM . Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity ^[3] . Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-N1584AR

Halofuginone hydrobromide (Standard) RU-19110 hydrobromide (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Dichroa febrifuga Lour Saxifragaceae Plants Source Classification	Reference Standards DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (hydrobromide) (Standard) is the analytical standard of Halofuginone (hydrobromide). This product is intended for research and analytical applications. Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM . Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity ^[3] . Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca ²⁺ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-150177

Mannose 6 phosphate	Human Gut Microbiota Metabolites Endogenous metabolite Source Classification	Drug Intermediate
Mannose 6 phosphate is an essential precursor for mannosyl glycoconjugates, including lipid-linked oligosaccharides (LLO; glucose3mannose9GlcNAc2-P-P-dolichol) used for protein N-glycosylation. Mannose 6 phosphate causes specific LLO cleavage. Mannose 6 phosphate causes specific degradation of G3M9Gn2-P-P-Dol. Complexes containing Mannose 6 phosphate can remodel the dermal collagen network, improve skin biomechanical properties, and reverse visible signs of aging. Mannose 6 phosphate can be used in research related to skin aging .

HY-N11072

Tremulacin	Structural Classification Natural Products Plants Maclurodendron oligophlebium (Merrill) T. G. Hartley Salicaceae Source Classification	Lipoxygenase Leukotriene Receptor Reactive Oxygen Species (ROS) MMP
Tremulacin is a 5-LOX inhibitor. Tremulacin reduces the biosynthesis of LTB₄ and slow-reacting substances of anaphylaxis. Tremulacin alleviates carrageenan-induced paw edema in rats, croton oil-induced ear edema in mice, and acetic acid-induced writhing response in mice. Tremulacin inhibits TNF-α-stimulated ROS production and MMP-1 expression, and promotes collagen secretion in human dermal fibroblasts. Tremulacin is investigated for studies on inflammation-related diseases ^[3].

HY-103701AR

L-Ascorbic acid 2-phosphate magnesium (Standard) 2-Phospho-L-ascorbic acid magnesium (Standard); LAA2P magnesium (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Endogenous metabolite Source Classification	Reference Standards Phosphatase Reactive Oxygen Species (ROS) Endogenous Metabolite
L-Ascorbic acid 2-phosphate (magnesium) (Standard) is the analytical standard of L-Ascorbic acid 2-phosphate (magnesium). This product is intended for research and analytical applications. L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) is a?long-acting?vitamin?C?derivative?that can stimulate collagen formation and expression . L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation ^[3].

HY-113025A

L-hydroxylysine dihydrochloride (2S,5R)-5-Hydroxylysine dihydrochloride	Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
L-hydroxylysine dihydrochloride ((2S,5R)-5-Hydroxylysine dihydrochloride), an amino acid, is exclusive to collagen protein, which is formed by posttranslational hydroxylation of some lysine residues .

HY-129502

Fibrostatin C P-23924C	Natural Products Microorganisms Source Classification	HIF/HIF Prolyl-Hydroxylase
Fibrostatin C (P-23924C) is an orally active prolyl hydroxylase inhibitor that also inhibits *collagen* biosynthesis. Fibrostatin C also increases the number of cytoplasmic granules immunoreactive with antibodies to collagen I or III. Fibrostatin C inhibits the secretion of type I collagen in Tenon's capsule fibroblasts. Fibrostatin C is promising for research of the wound fibrotic response in the wound of glaucoma filtering surgery .

HY-N2892

Aristolactam A IIIa Aristololactam A IIIa; Sch 546909	Antibiotics Fissistigma balansae (A. DC.) Merr. Disease Research Plants Annonaceae Anticancer Other Antibiotics Source Classification	DYRK
Aristolactam A IIIa (Sch 546909) is an aristolactam-type alkaloid that can be isolated from Glycosmis chlorosperma. Aristolactam A IIIa is a DYRK1A Inhibitor. Aristolactam A IIIa inhibits platelet aggregation induced by arachidonic acid (AA), collagen and platelet-activating factor (PAF). Aristolactam A IIIa has strong cytotoxic effect on HeLa cells .

Cat. No.	Product Name	Chemical Structure

HY-B0166S

L-Ascorbic acid-13C6

L-Ascorbic acid- ¹³C₆ is the ¹³C-labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor ^[3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .

HY-B0166S8

L-Ascorbic acid-13C6-1

L-Ascorbic acid- ¹³C₆-1 (L-Ascorbate-1; Vitamin C- ¹³C₆-1) is a ¹³C labeled L-Ascorbic acid (HY-B0166) . L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Ca_v3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor ^[3] . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .

HY-B0166S1

L-Ascorbic acid-13C

L-Ascorbic acid- ¹³C is the ¹³C-labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor ^[3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .

HY-B0166S3

L-Ascorbic acid-13C-2
L-Ascorbic acid- ¹³C-2 is the ¹³C labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen

HY-40136S

cis-4-Hydroxy-L-proline-d3

cis-4-Hydroxy-L-proline-d₃ is the deuterium labeled cis-4-Hydroxy-L-proline (HY-40136). cis-4-Hydroxy-L-proline is an orally active proline analog and collagen production inhibitor. cis-4-Hydroxy-L-proline inhibits cell growth by preventing the deposition of triple helical collagen on the cell layer. cis-4-Hydroxy-L-proline inhibits N-nitrosomethylurea-induced breast tumor growth. cis-4-Hydroxy-L-proline improves lung compliance and reduces prostate weight. cis-4-Hydroxy-L-proline can be used in the study of hypoxic pulmonary hypertension ^[3] .

HY-B0166S2

L-Ascorbic acid-13C-1
L-Ascorbic acid- ¹³C-1 is the ¹³C labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen

HY-B0166S4

L-Ascorbic acid-13C-3
L-Ascorbic acid- ¹³C-3 is the ¹³C labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen

HY-W738852

Hydroxylysylpyridinoline-d6
Hydroxylysylpyridinoline-d₆ is deuterium labeled Pyridinoline. Pyridinoline, a fluorescent material, is a bone resorption biomarker. Pyridinoline also is a type crosslink of collagen .

Targets Recommended: Collagen

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0166GL

L-Ascorbic acid (GMP Like) L-Ascorbate (GMP Like); Vitamin C (GMP Like)	Reactive Oxygen Species (ROS) Apoptosis Calcium Channel Endogenous Metabolite	Neurological Disease Metabolic Disease Cancer
L-Ascorbic acid (GMP Like) is the GMP Like class L-Ascorbic acid (HY-B0166). L-Ascorbic acid (L-Ascorbate, Vitamin C), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Ca_v3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor ^[3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .

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