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Results for "

eIF2α

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Aminoacyl-tRNA Synthetase (1) AMPK (1) Apoptosis (22) ATF6 (2) Atg8/LC3 (5) Autophagy (11) Bcl-2 Family (8) c-Myc (1) Caspase (6) DNA/RNA Synthesis (2) Endogenous Metabolite (2) Environmental Pollutants (1) Epigenetic Reader Domain (1) Eukaryotic Initiation Factor (eIF) (17) Glutathione Peroxidase (2) HDAC (1) HSV (2) Interleukin Related (1) JAK (3) JNK (2) MDM-2/p53 (1) MetAP (1) Mitogen- and Stress-Activated Protein Kinase (MSK) (1) mTOR (1) NF-κB (1) Nucleoside Antimetabolite/Analog (1) Orthopoxvirus (1) p38 MAPK (2) p62 (3) PARP (2) PD-1/PD-L1 (1) PERK (11) Phosphatase (7) Potassium Channel (2) Protein Arginine Deiminase (1) Reactive Oxygen Species (ROS) (6) Reference Standards (3) SOD (1) STAT (3) STING (1)
By Research Areas:	Cancer (31) Cardiovascular Disease (9) Endocrinology (2) Infection (5) Inflammation/Immunology (10) Metabolic Disease (5) Neurological Disease (5)
Oligonucleotides:	Nucleoside Analogs (1) Uridine (1)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12495

ISRIB (trans-isomer) 45+ Cited Publications	PERK Autophagy Apoptosis	Neurological Disease
ISRIB (trans-isomer) is a potent inhibitor of PERK with an IC₅₀ of 5 nM. ISRIB potently reverses the effects of eIF2α phosphorylation (IC₅₀=5 nM).

HY-15486

Salubrinal 35+ Cited Publications	Phosphatase HSV Autophagy Apoptosis	Infection Inflammation/Immunology Cancer
Salubrinal is a cell-permeable and selective inhibitor of eIF2α dephosphorylation . Salubrinal acts as a dual-specificity phosphatase 2 (Dusp2) inhibitor and suppresses inflammation in anti-collagen antibody-induced arthritis ^[2]. Salubrinal has antiviral activity against HSV-1 and inhibits dephosphorylation of *eIF2α* mediated by the HSV-1 protein ICP34.5 .

HY-112582

N1-Methylpseudouridine 1 Publications Verification 1-Methylpseudouridine; N1-methyl-pseudouridine	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Inflammation/Immunology
N1-methyl-pseudouridine (1-Methylpseudouridine), a methylpseudouridine, outperforms 5 mC and 5 mC/N1-methyl-pseudouridine in translation. N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density .

HY-112654

GCN2iB Maximum Cited Publications 60 Publications Verification	Eukaryotic Initiation Factor (eIF) Glutathione Peroxidase	Cardiovascular Disease Metabolic Disease Cancer
GCN2iB is an ATP-competitive, selective *GCN2* inhibitor with an IC₅₀ of 2.4 nM. GCN2iB inhibits the activation of the GCN2 pathway and upregulates GPX4. GCN2iB enhances the anticancer effect of ASNase against acute lymphoblastic leukemia. GCN2iB increases left ventricular ejection fraction, while reducing fasting blood glucose and myocardial fibrosis. GCN2iB can be used in research related to acute lymphoblastic leukemia, acute myeloid leukemia and diabetic cardiomyopathy ^[2].

HY-W050044

L-Azetidine-2-carboxylic acid 1 Publications Verification	Endogenous Metabolite PERK Atg8/LC3 Autophagy Bcl-2 Family Apoptosis Eukaryotic Initiation Factor (eIF) ATF6	Cardiovascular Disease Neurological Disease Metabolic Disease Endocrinology Cancer
L-Azetidine-2-carboxylic acid is a proline analog. L-Azetidine-2-carboxylic acid upregulates the lipid autophagy marker LC3-II via activation of the PERK pathway. L-Azetidine-2-carboxylic acid increases pro-apoptotic BAX protein. L-Azetidine-2-carboxylic acid induces ATF6 cleavage and upregulates phosphorylated *eIF2α* levels. L-Azetidine-2-carboxylic acid induces ER stress, inducing protein misfolding and aggregation. L-Azetidine-2-carboxylic acid shows teratogenic, pro-inflammatory and pro-apoptotic effects ^[2] .

HY-100548

GSK621 5+ Cited Publications	AMPK Autophagy Apoptosis	Cancer
GSK621 is a specific AMPK activator, with IC₅₀ values of 13-30 μM for AML cells. GSK621 induces autophagy and apoptosis. GSK621 induces *eiF2α* phosphorylation-a hallmark of UPR activation .

HY-147832

EIF2α activator 2	Eukaryotic Initiation Factor (eIF)	Cancer
EIF2α activator 2 (Compound 1) is an activator of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. EIF2α activator 2 exhibits high potency in SRB cell proliferation assays (IC₅₀=0.46 μM). EIF2α activator 2 exhibits antiproliferative activity againist K562 and PBMC cells with IC₅₀s of 4.79 and 10.52 μM, respectively .

HY-111022

Icerguastat 3 Publications Verification Sephin1; IFB-088	Phosphatase	Infection Inflammation/Immunology
Icerguastat (Sephin1), a derivative of Guanabenz lacking the α2-adrenergic activity, is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). Icerguastat inhibits eIF2α dephosphorylation, thereby prolonging the protective response. Anti-prion effect ^[2] .

HY-15969

Sal003 4 Publications Verification	Phosphatase Apoptosis	Cancer
Sal003 is a potent, specific and cell-permeable inhibitor of the *eukaryotic translation initiation factor 2α (eIF2α) phosphatase*. Sal003 is a derivative of salubrinal .

HY-118266

BTdCPU 3 Publications Verification	Phosphatase Apoptosis	Cancer
BTdCPU is a potent heme regulated inhibitor kinase (HRI) activator that promotes *eIF2α* phosphorylation and induces apoptosis in Dexamethasone (HY-14648) (Dex)-resistant cancer cells. BTdCPU can be used in the study of cancers such as multiple myeloma and Dex-resistant multiple myeloma ^[2].

HY-147831

HR-19011	Eukaryotic Initiation Factor (eIF) Epigenetic Reader Domain	Cancer
HR-19011 is an *eIF2α* phosphorylation activator targeting heme-regulated inhibitor HRI (EIF2AK1). HR-19011 exhibits growth inhibitory activity against K562 cells with an IC₅₀ value of 3.91 µM. HR-19011 inhibits the growth of hematologic malignancies by targeting HRI to activate the integrated stress response via the HRI-eIF2α-ATF4 axis. HR-19011 shows good safety in vivo. HR-19011 can be used for research on hematologic malignancies (leukemia) ^[2].

HY-101997

BEPP hydrochloride	Orthopoxvirus Apoptosis Caspase Bcl-2 Family Akt	Infection Cancer
BEPP hydrochloride is a double-stranded RNA-dependent protein kinase (PKR) modulator. BEPP hydrochloride enhances the phosphorylation levels of PKR and eIF2α, activates caspase-3, upregulates the pro-apoptotic protein BAX, and downregulates the anti-apoptotic protein *Bcl-2. BEPP hydrochloride inhibits vaccinia virus replication and exhibits selective cytotoxicity in cells expressing PKR*. BEPP hydrochloride can be used in research related to cancer and viral infections .

HY-W010451

1,2,4-Trihydroxybenzene Hydroxyhydroquinone	PERK Eukaryotic Initiation Factor (eIF) Potassium Channel Apoptosis	Cardiovascular Disease Cancer
1,2,4-Trihydroxybenzene (Hydroxyhydroquinone) is an ER stress inducer that targets proteins such as PKR-like ER kinase PERK to induce cytotoxicity. 1,2,4-Trihydroxybenzene selectively activates *eIF2α* phosphorylation, activates the *PERK-eIF2α* signaling pathway and induces stress granule formation. 1,2,4-Trihydroxybenzene subsequently exacerbates oxidative stress and causes DNA double-strand breaks, destroying organelles such as mitochondria and ER, and inducing cell death. 1,2,4-Trihydroxybenzene also has the potential to exhibit anti-tumor effect, increase blood pressure, and relieve spasm ^[2] .

HY-130240

GCN2-IN-6 3 Publications Verification	Eukaryotic Initiation Factor (eIF)	Cancer
GCN2-IN-6 (Compound 6d) is a potent, and orally available *GCN2* inhibitor confirmed by in-house enzymatic (IC₅₀ of 1.8 nM) and cellular assays (IC₅₀ of 9.3 nM). GCN2-IN-6 is also a eIF2α kinase PERK inhibitor with an IC₅₀ of 0.26 nM (in enzymatic assay) and 230 nM (in cells) . GCN2-IN-6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-172815

IDB-001	JNK Eukaryotic Initiation Factor (eIF) p38 MAPK	Cancer
IDB-001 is a human ribosomal peptidyl transferase center (PTC) inhibitor that induces conformational changes and blocks translational elongation in specific sequence contexts through complementary interactions with Asp/Glu residues in nascent polypeptides. IDB-001 preferentially stalls ribosomes at positions containing acidic peptide motifs, thereby inhibiting cancer cell proliferation, and activates the integrated stress response via *eIF2α* phosphorylation at high concentrations. In addition, IDB-001 mildly triggers ribotoxic stress responses through phosphorylation of JNK and p38. IDB-001 has been applied to mechanistic studies of triple-negative breast cancer .

HY-158196

*PERK/eIF2α* activator 1**	PERK Apoptosis	Cancer
PERK/eIF2α activator 1 (compound V8) is a flavonoid with an anti-tumor activity. PERK/eIF2α activator 1 induces apoptosis and activates the PERK-eIF2α-ATF4 pathway. PERK/eIF2α activator 1 inhibits HepG2 cell proliferation with an IC₅₀ value of 23 μM .

HY-145835

PERK-IN-5	PERK	Cancer
PERK-IN-5 is a highly potent, selectively and orally bioavailable PERK inhibitor (IC₅₀s of 2 and 9 nM for PERK and p-eIF2α, respectively). PERK-IN-5 can significantly inhibit tumor growth in the 786-O renal cell carcinoma xenograft tumor model .

HY-121337

Flurochloridone R-40244	Environmental Pollutants Apoptosis Bcl-2 Family	Others
Flurochloridone (R-40244) is a selective preemergence and persistent herbicide. Flurochloridone induces endoplasmic reticulum (ER) stress and activated unfolded protein response (UPR) signaling pathways. Flurochloridone impairs cell viability and induces cytotoxicity and apoptosis mediated by ER stress via activating *eIF2α-ATF4/ATF6-CHOP-Bim/Bax* signaling pathways in TM4 cells ^[2].

HY-112903A

YW3-56 hydrochloride	Protein Arginine Deiminase MDM-2/p53 PERK mTOR Autophagy	Cancer
YW3-56 (hydrochloride) is a PAD inhibitor. YW3-56 (hydrochloride) activates p53 target genes. YW3-56 (hydrochloride) activates ATF and blocks autophagy flux. YW3-56 induces ER stress through the *PERK-eIF2α-ATF4* signaling cascade and inhibits the mTOR signaling. YW3-56 (hydrochloride) inhibits triple-negative breast cancer .

HY-13559

Atiprimod Azaspirane ; SKF 106615-12; SKF 106615A12	STAT Apoptosis Autophagy Reactive Oxygen Species (ROS) Caspase Bcl-2 Family p62 Atg8/LC3 PARP NF-κB PERK JAK	Cardiovascular Disease Inflammation/Immunology Cancer
Atiprimod (Azaspirane) is a STAT3 inhibitor with antitumor, anti-inflammatory, and anti-angiogenic activities. Atiprimod blocks the signaling pathways of IL-6 and VEGF by inhibiting the phosphorylation of signal transducer and activator of STAT3. Atiprimod blocks the JAK-STAT signaling pathway by inhibiting the phosphorylation of *JAK2* and JAK3. Atiprimod also inhibits cell proliferation, induces cell cycle arrest, and induces autophagy and apoptosis. Atiprimod triggers persistent ER stress-mediated apoptosis in breast cancer cells by activating the *PERK/eIF2α/ATF4/CHOP* axis and inhibiting the nuclear translocation of STAT3/NF-κB. Atiprimod shows great anti-tumor activities in tumor xenograft mouse models. Atiprimod can be used for the study of pituitary adenoma, breast cancer, multiple myeloma and acute myeloid leukemia (AML) ^[2] .

HY-15486R

Salubrinal (Standard)	Phosphatase HSV Autophagy Apoptosis	Infection Inflammation/Immunology Cancer
Salubrinal (Standard) is the analytical standard of Salubrinal. This product is intended for research and analytical applications. Salubrinal is a cell-permeable and selective inhibitor of eIF2α dephosphorylation . Salubrinal acts as a dual-specificity phosphatase 2 (Dusp2) inhibitor and suppresses inflammation in anti-collagen antibody-induced arthritis ^[2]. Salubrinal has antiviral activity against HSV-1 and inhibits dephosphorylation of eIF2α mediated by the HSV-1 protein ICP34.5 .

HY-E70728

HRI Recombinant Human Active Protein Kinase	Eukaryotic Initiation Factor (eIF)	Inflammation/Immunology
Heme-regulated inhibitory (HRI) is an eIF2α kinase, which induces a cytosolic unfolded protein response to prevent aggregation of innate immune signalosomes. HRI Recombinant Human Active Protein Kinase is a recombinant HRI protein that can be used to study HRI-related functions .

HY-W050044R

L-Azetidine-2-carboxylic acid (Standard)	Reference Standards Endogenous Metabolite PERK Atg8/LC3 Autophagy Bcl-2 Family Apoptosis Eukaryotic Initiation Factor (eIF) ATF6	Cardiovascular Disease Neurological Disease Metabolic Disease Endocrinology Cancer
L-Azetidine-2-carboxylic acid is a proline analog. L-Azetidine-2-carboxylic acid upregulates the lipid autophagy marker LC3-II via activation of the PERK pathway. L-Azetidine-2-carboxylic acid increases pro-apoptotic BAX protein. L-Azetidine-2-carboxylic acid induces ATF6 cleavage and upregulates phosphorylated eIF2α levels. L-Azetidine-2-carboxylic acid induces ER stress, inducing protein misfolding and aggregation. L-Azetidine-2-carboxylic acid shows teratogenic, pro-inflammatory and pro-apoptotic effects ^[2] .

HY-13559A

Atiprimod dimaleate Azaspirane dimaleate; SKF 106615-12 dimaleate; SKF 106615A12 dimaleate	STAT Apoptosis Caspase Interleukin Related Autophagy Reactive Oxygen Species (ROS) Atg8/LC3 p62 JAK	Cardiovascular Disease Inflammation/Immunology Cancer
Atiprimod (Azaspirane) (dimaleate) is a STAT3 inhibitor with antitumor, anti-inflammatory, and anti-angiogenic activities. Atiprimod blocks the signaling pathways of IL-6 and VEGF by inhibiting the phosphorylation of signal transducer and activator of STAT3. Atiprimod blocks the JAK-STAT signaling pathway by inhibiting the phosphorylation of *JAK2* and JAK3. Atiprimod also inhibits cell proliferation, induces cell cycle arrest, and induces autophagy and apoptosis. Atiprimod triggers persistent ER stress-mediated apoptosis in breast cancer cells by activating the *PERK/eIF2α/ATF4/CHOP* axis and inhibiting the nuclear translocation of STAT3/NF-κB. Atiprimod shows great anti-tumor activities in tumor xenograft mouse models. Atiprimod can be used for the study of pituitary adenoma, breast cancer, multiple myeloma and acute myeloid leukemia (AML) ^[2] .

HY-110102

Atiprimod hydrochloride Azaspirane hydrochloride; SKF 106615-12 hydrochloride; SKF 106615	JAK STAT Apoptosis Autophagy Reactive Oxygen Species (ROS) Caspase Atg8/LC3 p62	Cardiovascular Disease Inflammation/Immunology Cancer
Atiprimod (Azaspirane) hydrochloride is a STAT3 inhibitor with antitumor, anti-inflammatory, and anti-angiogenic activities. Atiprimod blocks the signaling pathways of IL-6 and VEGF by inhibiting the phosphorylation of signal transducer and activator of STAT3. Atiprimod blocks the JAK-STAT signaling pathway by inhibiting the phosphorylation of *JAK2* and JAK3. Atiprimod also inhibits cell proliferation, induces cell cycle arrest, and induces autophagy and apoptosis. Atiprimod triggers persistent ER stress-mediated apoptosis in breast cancer cells by activating the *PERK/eIF2α/ATF4/CHOP* axis and inhibiting the nuclear translocation of STAT3/NF-κB. Atiprimod shows great anti-tumor activities in tumor xenograft mouse models. Atiprimod can be used for the study of pituitary adenoma, breast cancer, multiple myeloma and acute myeloid leukemia (AML) ^[2] .

HY-110365

Icerguastat Carbonate Sephin1 Carbonate; IFB-088 Carbonate	Phosphatase	Infection
Icerguastat (Sephin1) Carbonate, a derivative of Guanabenz lacking the α2-adrenergic activity, is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). Icerguastat Carbonate inhibits eIF2α dephosphorylation, thereby prolonging the protective response. Anti-prion effect ^[2] .

HY-114568

AMC-01	Eukaryotic Initiation Factor (eIF) Apoptosis	Inflammation/Immunology
AMC-01 is a potent chemical probe that regulates *eIF2-α* activity. AMC-01 induces protein kinase RNA activation (PKR) kinase and nuclear factor κb (NF-κB). AMC-01 inhibits apoptosis .

HY-W010451R

1,2,4-Trihydroxybenzene (Standard) Hydroxyhydroquinone (Standard)	Reference Standards PERK Potassium Channel Apoptosis Eukaryotic Initiation Factor (eIF)	Cardiovascular Disease Cancer
1,2,4-Trihydroxybenzene (Hydroxyhydroquinone) (Standard) is the analytical standard of 1,2,4-Trihydroxybenzene (HY-W010451). This product is intended for research and analytical applications. 1,2,4-Trihydroxybenzene (Hydroxyhydroquinone) is an ER stress inducer that targets proteins such as PKR-like ER kinase PERK to induce cytotoxicity. 1,2,4-Trihydroxybenzene selectively activates *eIF2α* phosphorylation, activates the *PERK-eIF2α* signaling pathway and induces stress granule formation. 1,2,4-Trihydroxybenzene subsequently exacerbates oxidative stress and causes DNA double-strand breaks, destroying organelles such as mitochondria and ER, and inducing cell death. 1,2,4-Trihydroxybenzene also has the potential to exhibit anti-tumor effect, increase blood pressure, and relieve spasm ^[2] .

HY-18956A

(E/Z)-Icerguastat hydrochloride (E/Z)-Sephin1 hydrochloride; (E/Z)-IFB-088 hydrochloride	Phosphatase	Neurological Disease
(E/Z)-Icerguastat hydrochloride ((E/Z)-Sephin1 hydrochloride) is a selective inhibitor with activity that prolongs the phosphorylation effects of eIF2α. (E/Z)-Icerguastat hydrochloride protects cells from defects in proteostasis. (E/Z)-Icerguastat hydrochloride was shown to significantly extend the survival of infected prion mice in a mouse model. (E/Z)-Icerguastat hydrochloride effectively reduces PrPSc expression and prion sequence activity in various neuronal cell lines persistently infected with different prion strains .

HY-121337R

Flurochloridone (Standard) R-40244 (Standard)	Reference Standards Apoptosis Bcl-2 Family	Others
Flurochloridone (Standard) is the analytical standard of Flurochloridone. This product is intended for research and analytical applications. Flurochloridone (R-40244) is a selective preemergence and persistent herbicide. Flurochloridone induces endoplasmic reticulum (ER) stress and activated unfolded protein response (UPR) signaling pathways. Flurochloridone impairs cell viability and induces cytotoxicity and apoptosis mediated by ER stress via activating eIF2α-ATF4/ATF6-CHOP-Bim/Bax signaling pathways in TM4 cells ^[2].

HY-138844

3-AP-Me	Eukaryotic Initiation Factor (eIF) p38 MAPK JNK Apoptosis	Cancer
3-AP-Me is a dimethyl derivative of the nucleotide reductase inhibitor 3-AP (SML0568). 3-AP-Me can activate the endoplasmic reticulum (ER) stress pathway by promoting the phosphorylation of *eIF2α* and increasing the gene expression of transcription factors ATF4 and ATF6, leading to cell apoptosis. Additionally, 3-AP-Me can activate the stress kinases c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases. 3-AP-Me also leads to the upregulation of the spliced mRNA variant XBP1, can be used in cancer research .

HY-158205

HPO-DAEE 4-Hydroperoxy-2-decenoic acid ethyl ester	Reactive Oxygen Species (ROS) HDAC SOD	Inflammation/Immunology Cancer
HPO-DAEE (4-Hydroperoxy-2-decenoic acid ethyl ester) elicits nuclear accumulation of Nrf2 and activated antioxidant response element (ARE). HPO-DAEE induces antioxidant genes upregulation (eg: HO-1) through Nrf2-ARE signaling. HPO-DAEE induces reactive oxygen species generation. HPO-DAEE also inhibits histone deacetylase and upregulate expression of extracellular superoxide dismutase via histone acetylation. HPO-DAEE protects against 6-hydroxydopamine-induced cell death via activation of Nrf2-ARE and eIF2α-ATF4 pathways .

HY-181959

APL-4098	Eukaryotic Initiation Factor (eIF)	Cancer
APL-4098 is an orally active, selective, ATP-competitive *GCN2* inhibitor with a K_i of 4.39 nM and a K_d of 2.9 nM. APL-4098 reduces the phosphorylation level of *eIF2α* and the expression level of ATF4. APL-4098 impairs mitochondrial function and exerts cytotoxic effects on primary acute myeloid leukemia cells. APL-4098 is applicable to research related to acute myeloid leukemia .

HY-183704

ISR activator-5	Eukaryotic Initiation Factor (eIF) Mitogen- and Stress-Activated Protein Kinase (MSK)	Neurological Disease Metabolic Disease Cancer
ISR activator-5 is an *eIF2B* modulator and integrated stress response (ISR) activator. ISR activator-5 stabilises the inactive I-state of eIF2B, inhibits protein synthesis, and activates canonical ISR pathways without inducing *eIF2α* phosphorylation. ISR activator-5 can be used for the research of cancer, neurologic and metabolic disorders .

HY-W046841

1,3-Bis[3,5-bis(trifluoromethyl)phenyl]urea	Eukaryotic Initiation Factor (eIF)	Cancer
1,3-Bis[3,5-bis(trifluoromethyl)phenyl]urea is a potent activator of eIF2α kinase heme regulated inhibitor. 1,3-Bis[3,5-bis(trifluoromethyl)phenyl]urea reduces the abundance of eIF2·GTP·tRNA_i ^Met ternary complex. 1,3-Bis[3,5-bis(trifluoromethyl)phenyl]urea inhibits cancer cell proliferation .

HY-181087

Anticancer agent 296	PERK Apoptosis Autophagy Reactive Oxygen Species (ROS) Caspase Bcl-2 Family	Cancer
Anticancer agent 296 is a potent anticancer agent that activates the *PERK-eIF2α-CHOP* signaling pathway to induce endoplasmic reticulum stress, thereby regulating caspase and *Bcl-2* family proteins, ultimately leading to apoptosis. Anticancer agent 296 increases intracellular levels of reactive oxygen species (ROS), reduces mitochondrial membrane potential, and promotes Ca ²⁺ release. Anticancer agent 296 suppresses cell colony formation and S-phase cell proliferation, and induces autophagy. Anticancer agent 296 is applicable for research on non-small cell lung cancer (NSCLC) .

HY-112654A

GCN2iB acetate	Eukaryotic Initiation Factor (eIF) Glutathione Peroxidase	Cardiovascular Disease Metabolic Disease Cancer
GCN2iB acetate is an ATP-competitive, selective *GCN2* inhibitor with an IC₅₀ of 2.4 nM. GCN2iB acetate inhibits the activation of the GCN2 pathway and upregulates GPX4. GCN2iB acetate enhances the anticancer effect of ASNase against acute lymphoblastic leukemia. GCN2iB acetate increases left ventricular ejection fraction, while reducing fasting blood glucose and myocardial fibrosis. GCN2iB acetate can be used in research related to acute lymphoblastic leukemia, acute myeloid leukemia and diabetic cardiomyopathy ^[2].

HY-182360

Cytisine-platinum(IV) prodrug-1	PERK Eukaryotic Initiation Factor (eIF) Bcl-2 Family Apoptosis Reactive Oxygen Species (ROS) STING DNA/RNA Synthesis PD-1/PD-L1	Cancer
Cytisine-Platinum(IV) Prodrug-1 is a Pt(IV) prodrug incorporating the natural compound Cytisine (HY-N0175) with antiproliferative activity against tumor cells. Cytisine-Platinum(IV) Prodrug-1 promotes calcium transfer across the IP3R1-GRP75-VDAC1 axis to drive mitochondrial calcium overload. Cytisine-Platinum(IV) Prodrug-1 initiates unfolded protein response via PERK, *eIF2α, ATF4, and CHOP* to modulate *Bcl-2* and Bax, triggering apoptosis. Cytisine-Platinum(IV) Prodrug-1 induces mitochondrial dysfunction, ROS production, reduced ATP synthesis, DNA damage, and S-phase cell cycle arrest. Cytisine-Platinum(IV) Prodrug-1 activates the cGAS-STING pathway, reduces PD-L1 expression, drives immunogenic cell death. Cytisine-Platinum(IV) Prodrug-1 exhibits high physiological stability, efficient cellular accumulation, and enhanced platinum-DNA binding, and inhibits tumor growth in mouse models with reduced systemic toxicity. Cytisine-Platinum(IV) Prodrug-1 can be used for the research of lung cancer .

HY-183004

NCP26	Aminoacyl-tRNA Synthetase Apoptosis Caspase PARP c-Myc	Cancer
NCP26 is an ATP-competitive ProRS inhibitor (with a K_D of 271 nM in the absence of proline, and a K_D of 0.35 nM in the presence of 100 μM proline). NCP26 activates AAR, induces G0/G1 phase arrest, Apoptosis, Caspase cleavage, and PARP cleavage. NCP26 downregulates MYC, TCF3, and CCND1. NCP26 inhibits the growth of multiple myeloma cells. NCP26 can be used for the research of multiple myeloma ^[2].

HY-182781

Anticancer agent 313	MetAP	Cancer
Anticancer agent 313 is a *MetAP2* inhibitor with an IC₅₀ of 4.11 μM. Anticancer agent 313 activates the transcription factor ATF4 via a non-canonical mTORC1-dependent pathway. Anticancer agent 313 inhibits cancer cell proliferation. Anticancer agent 313 is applicable to the research of breast cancer and pancreatic cancer .

L-Azetidine-2-carboxylic acid 1 Publications Verification	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite PERK Atg8/LC3 Autophagy Bcl-2 Family Apoptosis Eukaryotic Initiation Factor (eIF) ATF6
L-Azetidine-2-carboxylic acid is a proline analog. L-Azetidine-2-carboxylic acid upregulates the lipid autophagy marker LC3-II via activation of the PERK pathway. L-Azetidine-2-carboxylic acid increases pro-apoptotic BAX protein. L-Azetidine-2-carboxylic acid induces ATF6 cleavage and upregulates phosphorylated *eIF2α* levels. L-Azetidine-2-carboxylic acid induces ER stress, inducing protein misfolding and aggregation. L-Azetidine-2-carboxylic acid shows teratogenic, pro-inflammatory and pro-apoptotic effects ^[2] .

1,2,4-Trihydroxybenzene Hydroxyhydroquinone	Cardiovascular Disease Microorganisms Classification of Application Fields Phenols Polyphenols Disease Research Fields Source Classification	PERK Eukaryotic Initiation Factor (eIF) Potassium Channel Apoptosis
1,2,4-Trihydroxybenzene (Hydroxyhydroquinone) is an ER stress inducer that targets proteins such as PKR-like ER kinase PERK to induce cytotoxicity. 1,2,4-Trihydroxybenzene selectively activates *eIF2α* phosphorylation, activates the *PERK-eIF2α* signaling pathway and induces stress granule formation. 1,2,4-Trihydroxybenzene subsequently exacerbates oxidative stress and causes DNA double-strand breaks, destroying organelles such as mitochondria and ER, and inducing cell death. 1,2,4-Trihydroxybenzene also has the potential to exhibit anti-tumor effect, increase blood pressure, and relieve spasm ^[2] .

L-Azetidine-2-carboxylic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite PERK Atg8/LC3 Autophagy Bcl-2 Family Apoptosis Eukaryotic Initiation Factor (eIF) ATF6
L-Azetidine-2-carboxylic acid is a proline analog. L-Azetidine-2-carboxylic acid upregulates the lipid autophagy marker LC3-II via activation of the PERK pathway. L-Azetidine-2-carboxylic acid increases pro-apoptotic BAX protein. L-Azetidine-2-carboxylic acid induces ATF6 cleavage and upregulates phosphorylated eIF2α levels. L-Azetidine-2-carboxylic acid induces ER stress, inducing protein misfolding and aggregation. L-Azetidine-2-carboxylic acid shows teratogenic, pro-inflammatory and pro-apoptotic effects ^[2] .

1,2,4-Trihydroxybenzene (Standard) Hydroxyhydroquinone (Standard)	Structural Classification Microorganisms Phenols Polyphenols Source Classification	Reference Standards PERK Potassium Channel Apoptosis Eukaryotic Initiation Factor (eIF)
1,2,4-Trihydroxybenzene (Hydroxyhydroquinone) (Standard) is the analytical standard of 1,2,4-Trihydroxybenzene (HY-W010451). This product is intended for research and analytical applications. 1,2,4-Trihydroxybenzene (Hydroxyhydroquinone) is an ER stress inducer that targets proteins such as PKR-like ER kinase PERK to induce cytotoxicity. 1,2,4-Trihydroxybenzene selectively activates *eIF2α* phosphorylation, activates the *PERK-eIF2α* signaling pathway and induces stress granule formation. 1,2,4-Trihydroxybenzene subsequently exacerbates oxidative stress and causes DNA double-strand breaks, destroying organelles such as mitochondria and ER, and inducing cell death. 1,2,4-Trihydroxybenzene also has the potential to exhibit anti-tumor effect, increase blood pressure, and relieve spasm ^[2] .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P705590

	EIF2AK4 Protein, Human (sf9, His-GST) eIF-2-alpha kinase GCN2; Eukaryotic translation initiation factor 2-alpha kinase 4; GCN2-like protein; GCN2; KIAA1338; EC:2.7.11.1	Human	Sf9 insect cells

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Host:	Mouse (1) Rabbit (9)
Reactivity:	Human (9) Rat (10) Mouse (10) Monkey (1) Chicken (1) Dog (1) Pig (1)
Application:	IHC-P (4) ICC/IF (5) IP (3) IHC-F (1) WB (10) FC (2) ELISA (4)
Isotype:	IgG (8) IgG1 (1) IgG, Kappa (1)
Conjugation:	Non-conjugated (10)
Clonality:	Polyclonal (1) Monoclonal (7) Recombinant (4)
Modification:	Phosphorylated (3) Unmodified (5)

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HY-P87923

	*Phospho-eIF2α* (Ser51) Antibody (YA7608)**	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat, Chicken, Pig, Dog
	Phospho-eIF2α (Ser51) Antibody (YA7608) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to Phospho-eIF2α (Ser51).

HY-P83763

	EIF2S1 Antibody(YA3562) eIF 2 alpha antibody; eIF 2 antibody; eIF 2A antibody; eIF 2alpha antibody; eIF-2-alpha antibody; eIF-2A antibody; eIF-2alpha antibody; eIF2 alpha antibody; eIF2 antibody; eIF2A antibody; eIF2S1 antibody; Eukaryotic translation initiation factor 2 subunit 1 alpha 35kDa antibody; IF2A_HUMAN antibody	WB, ICC/IF, IHC-P, FC, IP	Human, Mouse, Rat, Monkey
	EIF2S1 Antibody(YA3562) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to EIF2S1.

HY-P86419

	EIF2S1 Antibody (YA6111) eIF2S1; eIF2A; Eukaryotic translation initiation factor 2 subunit 1; Eukaryotic translation initiation factor 2 subunit alpha; eIF-2-alpha; eIF-2A; eIF-2alpha	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	EIF2S1 Antibody (YA6111) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to EIF2S1.

HY-P80811

	*Phospho-EIF2S1 (Ser51) Antibody (YA203)* 3 Publications Verification eIF2S1; eIF2A; Eukaryotic translation initiation factor 2 subunit 1; Eukaryotic translation initiation factor 2 subunit alpha; eIF-2-alpha; eIF-2A; eIF-2alpha	WB	Human, Mouse, Rat
	Phospho-EIF2S1 (Ser51) Antibody (YA203) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-EIF2S1 (Ser51).

HY-P80811A

	*Phospho-EIF2S1 (Ser51) Antibody (YA203)(PBS only)* eIF2S1; eIF2A; Eukaryotic translation initiation factor 2 subunit 1; Eukaryotic translation initiation factor 2 subunit alpha; eIF-2-alpha; eIF-2A; eIF-2alpha	WB	Human, Mouse, Rat
	Phospho-EIF2S1 (Ser51) Antibody (YA203) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-EIF2S1 (Ser51).

HY-P80781

	PERK Antibody (YA233) eIF2AK3; PEK; PERK; Eukaryotic translation initiation factor 2-alpha kinase 3; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; HsPEK	WB	Human, Mouse, Rat
	PERK Antibody (YA233) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PERK.

HY-P85324

	PERK Antibody (YA5016) eIF2AK3; PEK; PERK; Eukaryotic translation initiation factor 2-alpha kinase 3; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; HsPEK	WB, ELISA	Mouse, Rat
	PERK Antibody (YA5016) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PERK.

HY-P86542

	PERK Antibody (YA6234) eIF2AK3; PEK; PERK; Eukaryotic translation initiation factor 2-alpha kinase 3; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; HsPEK	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	PERK Antibody (YA6234) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PERK.

HY-P81190

	Phospho-PERK (Thr980) Antibody 2 Publications Verification p-PERK(Thr980); PERK(Phospho Thr980); PERK(Phospho T980); mo(Thr980)/hu (Thr982)/rat (Thr974); HRI; HsPEK; Pancreatic eIF2-alpha kinase; PEK; PRKR like endoplasmic reticulum kinase; WRS; DKFZp781H1925; EC 2.7.11.1; eIF2AK3; Eukaryotic translation initiation factor 2 alpha kinase 3; Heme regulated eIF2 alpha kinase.	WB, IHC-P, IHC-F, ICC/IF, FC	Human, Mouse, Rat
	Phospho-PERK (Thr980) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-PERK (Thr980).

HY-P80781A

	PERK Antibody (YA233)(PBS only) eIF2AK3; PEK; PERK; Eukaryotic translation initiation factor 2-alpha kinase 3; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; HsPEK	WB	Human, Mouse, Rat
	PERK Antibody (YA233) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PERK.

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HY-112582

N1-Methylpseudouridine 1 Publications Verification 1-Methylpseudouridine; N1-methyl-pseudouridine		Nucleoside Analogs Uridine
N1-methyl-pseudouridine (1-Methylpseudouridine), a methylpseudouridine, outperforms 5 mC and 5 mC/N1-methyl-pseudouridine in translation. N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density .

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