1257423-87-2
1257423-87-2
Chemical Structure
BTdCPU
- CAS No.: 1257423-87-2
- Formula:C13H8Cl2N4OS
- Molecular Weight:339.20
IUPAC Name: 1-(benzo[d][1,2,3]thiadiazol-6-yl)-3-(3,4-dichlorophenyl)urea
InChIKey: NUUSUAWULNXMGF-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C2N=NSC2=C1)NC3=CC=C(C(Cl)=C3)Cl
Biological Activity: BTdCPU is a potent heme regulated inhibitor kinase (HRI) activator that promotes eIF2α phosphorylation and induces apoptosis in Dexamethasone (HY-14648) (Dex)-resistant cancer cells. BTdCPU can be used in the study of cancers such as multiple myeloma and Dex-resistant multiple myeloma[1][2].
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BTdCPU | 99.03% | BTdCPU is a potent heme regulated inhibitor kinase (HRI) activator that promotes eIF2α phosphorylation and induces apoptosis in Dexamethasone (HY-14648) (Dex)-resistant cancer cells. BTdCPU can be used in the study of cancers such as multiple myeloma and Dex-resistant multiple myeloma. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.80
HY-148823RF03176 -
Similarity Score 0.74
HY-124018MMV665852 -
Similarity Score 0.71
HY-B1805Triclocarban -
Similarity Score 0.71
HY-W585956Triclocarban-13C6 -
Similarity Score 0.71
HY-153348p38 Kinase inhibitor 4 -
Similarity Score 0.66
HY-157482EBP-59 -
Similarity Score 0.65
HY-110158UNC2327 -
Similarity Score 0.63
HY-123665PSB-1410 -
Similarity Score 0.63
HY-W224634HSF1-IN-2 -
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References
- [1]. Burwick N, et al. The eIF2-alpha kinase HRI is a novel therapeutic target in multiple myeloma. Leuk Res. 2017 Apr;55:23-32. [Content Brief]
- [2]. Chen T, et al. Chemical genetics identify eIF2α kinase heme-regulated inhibitor as an anticancer target. Nat Chem Biol. 2011 Jul 17;7(9):610-6. [Content Brief]
