PSB-1410
Based on 1 Customer Validation
PSB-1410 is a monoamine oxidase B (MAO-B) inhibitor, with an IC50 of 0.227 nM against human MAO-B and an IC50 of 1.01 nM against rat MAO-B. PSB-1410 can be used for the research of Parkinson's disease.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.22%
- CAS. Nr.: 1494477-03-0
- Formel: C15H10Cl2N2O
- Molecular Weight:305.16
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
hMAO-B 0.227 nM (IC50) |
rMAO-B 1.01 nM (IC50) |
In Vitro
PSB-1410 (Compound 53) potently and selectively inhibits human MAO-B with an IC50 of 0.227 nM, and rat MAO-B with an IC50 of 1.01 nM, while only weakly inhibiting human and rat MAO-A[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS. Nr. 1494477-03-0
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Appearance Solid
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Molecular Weight 305.16
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Formel C15H10Cl2N2O
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Color White to off-white
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SMILES
O=C(C1=CC2=C(NC=C2)C=C1)NC3=CC=C(Cl)C(Cl)=C3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 125 mg/mL (409.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Protokoll
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Human pluripotent stem cell midbrain dopaminergic neuron differentiation
Human pluripotent stem cells are directed toward midbrain dopaminergic neurons by first inducing a neural floor-plate-like progenitor state, then patterning cells with ventralizing SHH signaling and midbrain/WNT-FGF cues, and finally maturing progenitors into neurons expressing dopaminergic markers such as TH, NURR1/NR4A2, PITX3, DAT/SLC6A3, VMAT2/SLC18A2, GIRK2/KCNJ6, FOXA2, LMX1A, and EN1. The main readouts are loss of pluripotency, acquisition of FOXA2+/LMX1A+ midbrain floor-plate progenitors, emergence of βIII-tubulin+/MAP2+ neurons, and production of TH+ dopaminergic neurons with molecular, dopamine-release, and electrophysiological features of midbrain dopaminergic identity.
Reinheit & Dokumentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.2770 mL | 16.3848 mL | 32.7697 mL | 81.9242 mL |
| 5 mM | 0.6554 mL | 3.2770 mL | 6.5539 mL | 16.3848 mL | |
| 10 mM | 0.3277 mL | 1.6385 mL | 3.2770 mL | 8.1924 mL | |
| 15 mM | 0.2185 mL | 1.0923 mL | 2.1846 mL | 5.4616 mL | |
| 20 mM | 0.1638 mL | 0.8192 mL | 1.6385 mL | 4.0962 mL | |
| 25 mM | 0.1311 mL | 0.6554 mL | 1.3108 mL | 3.2770 mL | |
| 30 mM | 0.1092 mL | 0.5462 mL | 1.0923 mL | 2.7308 mL | |
| 40 mM | 0.0819 mL | 0.4096 mL | 0.8192 mL | 2.0481 mL | |
| 50 mM | 0.0655 mL | 0.3277 mL | 0.6554 mL | 1.6385 mL | |
| 60 mM | 0.0546 mL | 0.2731 mL | 0.5462 mL | 1.3654 mL | |
| 80 mM | 0.0410 mL | 0.2048 mL | 0.4096 mL | 1.0241 mL | |
| 100 mM | 0.0328 mL | 0.1638 mL | 0.3277 mL | 0.8192 mL |
PSB-1410 Related Classifications
HY-123665 Related Classifications
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