533-73-3
Chemical Structure
1,2,4-Trihydroxybenzene
Synonym(s): Hydroxyhydroquinone
- CAS No.: 533-73-3
- Formula:C6H6O3
- Molecular Weight:126.11
IUPAC Name: benzene-1,2,4-triol
InChIKey: GGNQRNBDZQJCCN-UHFFFAOYSA-N
SMILES: OC1=CC=C(O)C=C1O
Biological Activity: 1,2,4-Trihydroxybenzene (Hydroxyhydroquinone) is an ER stress inducer that targets proteins such as PKR-like ER kinase PERK to induce cytotoxicity. 1,2,4-Trihydroxybenzene selectively activates eIF2α phosphorylation, activates the PERK-eIF2α signaling pathway and induces stress granule formation. 1,2,4-Trihydroxybenzene subsequently exacerbates oxidative stress and causes DNA double-strand breaks, destroying organelles such as mitochondria and ER, and inducing cell death. 1,2,4-Trihydroxybenzene also has the potential to exhibit anti-tumor effect, increase blood pressure, and relieve spasm[1][2][3][4].
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1,2,4-Trihydroxybenzene | 99.56% | 1,2,4-Trihydroxybenzene (Hydroxyhydroquinone) is an ER stress inducer that targets proteins such as PKR-like ER kinase PERK to induce cytotoxicity. 1,2,4-Trihydroxybenzene selectively activates eIF2α phosphorylation, activates the PERK-eIF2α signaling pathway and induces stress granule formation. 1,2,4-Trihydroxybenzene subsequently exacerbates oxidative stress and causes DNA double-strand breaks, destroying organelles such as mitochondria and ER, and inducing cell death. 1,2,4-Trihydroxybenzene also has the potential to exhibit anti-tumor effect, increase blood pressure, and relieve spasm. | ||||||||||||||||||||
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1,2,4-Trihydroxybenzene (Standard) | ≥98% | 1,2,4-Trihydroxybenzene (Hydroxyhydroquinone) (Standard) is the analytical standard of 1,2,4-Trihydroxybenzene (HY-W010451). This product is intended for research and analytical applications. 1,2,4-Trihydroxybenzene (Hydroxyhydroquinone) is an ER stress inducer that targets proteins such as PKR-like ER kinase PERK to induce cytotoxicity. 1,2,4-Trihydroxybenzene selectively activates eIF2α phosphorylation, activates the PERK-eIF2α signaling pathway and induces stress granule formation. 1,2,4-Trihydroxybenzene subsequently exacerbates oxidative stress and causes DNA double-strand breaks, destroying organelles such as mitochondria and ER, and inducing cell death. 1,2,4-Trihydroxybenzene also has the potential to exhibit anti-tumor effect, increase blood pressure, and relieve spasm. | ||||||||||||||||||||
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References
- [1]. Risa Kamae, et al. Hydroxyhydroquinone, a by-product of coffee bean roasting, increases intracellular Ca2+ concentration in rat thymic lymphocytes. Food Chem Toxicol. 2017 Apr;102:39-45. [Content Brief]
- [2]. Jung DM, et al. 1,2,4-trihydroxybenzene induces stress granule formation and causes DNA damage in human keratinocytes. Toxicol In Vitro. 2023 Oct;92:105638. [Content Brief]
- [3]. Park EJ, et al. 1,2,4-trihydroxybenzene induces non-apoptotic cell death via the structural damage of intracellular organelles. Toxicol Appl Pharmacol. 2024 Nov;492:117096. [Content Brief]
- [4]. Inoue S. Effects of 1,3,5-trihydroxybenzene and 2,4,6-trihydroxy-1-propiophenone on the smooth muscle organs. Jpn J Pharmacol. 1969 Jun;19(2):224-33. [Content Brief]
