2616821-91-9
2616821-91-9
Chemical Structure
PERK-IN-5
- CAS No.: 2616821-91-9
- Formula:C25H26F2N4O3
- Molecular Weight:468.50
IUPAC Name: (R)-2-amino-5-(4-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-2-ethylphenyl)-N-isopropylnicotinamide
InChIKey: YNDQMKBAYRFBMW-JOCHJYFZSA-N
SMILES: CCC1=C(C2=CN=C(N)C(C(NC(C)C)=O)=C2)C=CC(NC([C@@H](C3=CC(F)=CC(F)=C3)O)=O)=C1
Biological Activity: PERK-IN-5 is a highly potent, selectively and orally bioavailable PERK inhibitor (IC50s of 2 and 9 nM for PERK and p-eIF2α, respectively). PERK-IN-5 can significantly inhibit tumor growth in the 786-O renal cell carcinoma xenograft tumor model[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PERK-IN-5 | 99.07% | PERK-IN-5 is a highly potent, selectively and orally bioavailable PERK inhibitor (IC50s of 2 and 9 nM for PERK and p-eIF2α, respectively). PERK-IN-5 can significantly inhibit tumor growth in the 786-O renal cell carcinoma xenograft tumor model. | ||||||||||||||||||||
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References
Keywords
