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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
31 Results for "
endosomal escape
" in MedChemExpress (MCE) Product Catalog:
Products (31)
31 Results for "endosomal escape" in MCE Product Catalog:
1
Cat. No.: HY-P10152
CAS No.: 185462-59-3
Target:
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Cat. No.: HY-P4121
CAS No.: 1898254-09-5
Target:
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Cat. No.: HY-160852
CAS No.: 1829511-70-7
Target:
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YSK 12C4 is an ionizable cationic lipid primarily used to enhance siRNA cellular delivery via multifunctional envelope-type nanodevices (MEND). YSK 12C4 promotes siRNA uptake and endosomal escape, effectively silencing genes in human immune cell lines .
Cat. No.: HY-P10649
CAS No.: 1831064-62-0
Cat. No.: HY-P4118
CAS No.: 952754-66-4
Synonyms: Penetrating analog
Research Areas:
Synonyms: ARO-AAT sodium
Target:
Research Areas:
Fazirsiran sodium is a second-generation RNAi agent. Fazirsiran sodium consistes of a cholesterol-conjugated RNAi trigger (chol-RNAi) to selectively degrade Alpha1-antitrypsin (AAT) mRNA by RNAi and a melittin-derived peptide conjugated to N-acetylgalactosamine (NAG) formulated as the excipient EX1 to promote endosomal escape of the chol-RNAi in hepatocytes . Fazirsiran sodium can be used in the study of Alpha-1 Antitrypsin Deficiency (AATD) liver disease. AATD is caused by mutations in the alpha-1 antitrypsin (SERPINA1) gene.
Cat. No.: HY-P4087
CAS No.: 1417221-06-7
Cat. No.: HY-167015
CAS No.: 3117189-57-5
Cat. No.: HY-167012
CAS No.: 3027930-39-5
Cat. No.: HY-132604
CAS No.: 2175009-08-0
Synonyms: ARO-AAT
Target:
Research Areas:
Fazirsiran (ARO-AAT) is a second-generation RNAi agent. Fazirsiran consistes of a cholesterol-conjugated RNAi trigger (chol-RNAi) to selectively reduce Alpha1-antitrypsin (AAT) synthesis and a melittin-derived peptide conjugated to N-acetylgalactosamine (NAG) formulated as the excipient EX1 to promote endosomal escape of the chol-RNAi in hepatocytes . Fazirsiran can be used in the study of Alpha-1 Antitrypsin Deficiency (AATD) liver disease. Alpha-1 antitrypsin deficiency (AATD) is caused by mutations in the alpha-1 antitrypsin (SERPINA1) gene.
Cat. No.: HY-P4087B
Cat. No.: HY-174286
CAS No.: 119904-40-4
C16-18:1 PE is a lipid. C16-18:1 PE has the activity of promoting membrane fusion and enhancing endosomal escape, which can significantly improve the delivery efficiency of mRNA. C16-18:1 PE is used in the synthesis of lipid nanoparticles (LNP) .
Cat. No.: HY-167004
CAS No.: 3076338-50-3
Cat. No.: HY-167004A
CAS No.: 3076338-32-1
Cat. No.: HY-167011
CAS No.: 3055572-07-8
Cat. No.: HY-177344
CAS No.: 2857089-36-0
Target:
Research Areas:
IAJD-97 is a single-component ionizable amphiphilic Janus dendrimer carrier targeting mRNA delivery, which self-assembles into dendrimersomes (DNPs) via pH-responsive mechanisms to efficiently encapsulate and protect mRNA, while facilitating cellular uptake and endosomal escape through ionizable amine groups. IAJD-97 is promising for research of cancers .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
