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fermentation broth

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By Targets:	Antibiotic (9) Bacterial (9) COX (1) Drug Derivative (2) Endogenous Metabolite (3) Endothelin Receptor (1) Fungal (3) HBV (1) Interleukin Related (2) NF-κB (1) NO Synthase (1) NOD-like Receptor (NLR) (1) P2Y Receptor (1) p38 MAPK (1) Parasite (1) Reactive Oxygen Species (ROS) (2) Reference Standards (1) TNF Receptor (1) Tyrosinase (2)
By Research Areas:	Cancer (1) Cardiovascular Disease (2) Infection (19) Inflammation/Immunology (4)

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Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W015650

Indole-2-carbaldehyde	Drug Derivative	Others
Indole-2-carbaldehyde is an indole derivative that can be used to reduce or remove localized fat deposits and/or tighten loose skin and soft tissues. Indole-2-carbaldehyde can be isolated from the fermentation broth of the coral symbiotic actinomycete Pseudonocardia sp. SCSIO 11457 and is used in cosmetic applications or pharmaceutical production .

HY-N1780

3,4-Dimethoxyphenol	Tyrosinase Bacterial	Infection
3,4-Dimethoxyphenol is a plant-derived phenylpropanoid compound and can use as a whitening agent in cosmetics. 3,4-Dimethoxyphenol exhibits broad-spectrum antimicrobial activity. 3,4-Dimethoxyphenol has tyrosinase-inhibiting activity. 3,4-Dimethoxyphenol has potent antioxidant effect isolated from the bacterial fermentation broth. 3,4-Dimethoxyphenol can be used for the study of infection .

HY-125682

Amphotericin A	Fungal	Infection
Amphotericin A is a tetraenic polyene antifungal agent, produced in the fermentation broth of Amphotericin B (HY-B0221). Amphotericin A has a structure identical to Amphotericin B except for a single bond between carbons 28 and 29 instead of a double bond. Amphotericin A can be used for research on fungal infection .

HY-118331

Kazusamycin B PD 124895; CL-1957E	Antibiotic	Infection Cancer
Kazusamycin B is an antibiotic that could be isolated from the fermentation broth of Streptomyces sp. No. 81-484. Kazusamycin B inhibits cell growth and arrests cell cycle at G1 phase. Kazusamycin B can be used in research of cancer .

HY-148209

Balhimycin	Antibiotic Bacterial	Infection
Balhimycin is a glycopeptide antibiotic, found from the fermentation broth of a Amycolatopsis sp. Balhimycin shows anti-bacterial activity against staphylococci and anaerobes .

HY-117986

AB 3217-A Antibiotic AB3217A	Parasite	Infection
AB 3217-A, an anti-mite substance, can be isolated from the fermentation broth of a streptomycete strain .

HY-N7242

Plicacetin	Antibiotic	Infection
Plicacetin is a crystalline antibiotic isolated from the fermentation broth of Streptomyces actinomycetes and is structurally similar to Amicetin (HY-120383) and Bamicetin. .

HY-N13998

Cephalonic acid	Bacterial	Infection
Cephalonic acid is a pentaprenyl terpenoid compound that can be isolated from the fermentation broth of Cephaloscorlum caerulens. Cephalonic acid has weak antibacterial activity against Staphylococcus aureus .

HY-N14975

3,4-Dimethoxytropolone	Bacterial	Infection Inflammation/Immunology
3,4-Dimethoxytropolone can be isolated from Streptoverticillium hadanonense fermentation broths and found to be active against both Gram-positive and Gram-negative bacteria .

HY-N12483

Catenulopyrizomicin A	HBV	Infection
Catenulopyrizomicin A has a thiazolyl pyridine moiety. Catenulopyrizomicin A can be isolated from the fermentation broth of rare actinomycete Catenuloplanes sp. Catenulopyrizomicin A has anti-Hepatitis B virus activity .

HY-136817

Nanaomycin αA OM173-αA; Nanaomycin A methyl ester	Antibiotic	Infection
Nanaomycin αA (OM173-αA) is an antibiotic with antimicrobial activity. Nanaomycin αA can be isolated from a fermentation broth of Streptomyces hebeiensis derived from lichen .

HY-125414

Lydicamycin	Antibiotic Bacterial	Infection
Lydicamycin is an antibiotic isolated from the fermentation broth of an actinomycete strain identified as Streptomyces lydicus. Lydicamycin is active against Gram-positive bacteria and a certain yeast, but inactive against Gram-negative bacteria .

HY-W971376

Cyclo(Ala-Tyr)	Others	Others
Cyclo(Ala-Tyr) is a cyclic dipeptide that can be isolated from the fermentation broth of the marine microorganism Bacillus marinus B-9987 isolated from the rhizosphere tissue of Suaeda salsa in the intertidal zone of Bohai Bay, China .

HY-N8329

AS-2077715	Fungal Antibiotic	Infection
AS-2077715 is an antifungal agent that shows inhibitory activity against the Trichophyton species. AS-2077715 can be obtained from the fermentation broth of Capnodium sp. 339855. AS-2077715 can be used to study fungal infections .

HY-N14134

Deoxyfrenolicin	Antibiotic Bacterial	Infection
Deoxyfrenolicin is a quinone antibiotic that can be isolated from the fermentation broth of the Streptomyces roseofulvus strain AM-3867. Deoxyfrenolicin belongs to the frenolicin class of antibiotics. Deoxyfrenolicin exhibits antibacterial activity in vitro and can effectively inhibit the activity of Mycoplasma gallisepticum .

HY-N12322

Dihydrotetrodecamycin	Antibiotic Bacterial	Infection
Dihydrotetrodecamycin is an antibiotic that can be isolated from the fermentation broth of Streptomyces nashvillensis MJ885-mF8. Dihydrotetrodecamycin has MIC values of 50 mg/mL against both Pasteurella piscicida sp. 639 and P. piscicida sp. 6356 .

HY-123457

PF-1163A	Fungal	Infection
PF-1163A is an antifungal agent that inhibits Ergosterol (HY-N0181) synthesis (IC₅₀ = 12 ng/mL), which is found in a fermentation broth of Penicillium sp. PF-1163A also inhibits C-4 sterol methyl oxidase with an MIC value of 12.5 µg/mL .

HY-N1780R

3,4-Dimethoxyphenol (Standard)	Reference Standards Tyrosinase Bacterial	Infection
3,4-Dimethoxyphenol (Standard) is the analytical standard of Lithocholic acid. This product is intended for research and analytical applications. 3,4-Dimethoxyphenol is a plant-derived phenylpropanoid compound and can use as a whitening agent in cosmetics. 3,4-Dimethoxyphenol exhibits broad-spectrum antimicrobial activity. 3,4-Dimethoxyphenol has tyrosinase-inhibiting activity. 3,4-Dimethoxyphenol has potent antioxidant effect isolated from the bacterial fermentation broth. 3,4-Dimethoxyphenol can be used for the study of infection .

HY-117204

AA-57	Antibiotic	Infection
AA-57 is an acidic lipophilic antibiotic isolated from the fermentation broth of Actinomycetes strain AA-57. The AA-57 strain can be isolated from a soil sample collected in Koriyama City, Fukushima Prefecture, Japan. AA-57 has antibacterial properties against Gram-positive bacteria, Gram-negative bacteria, and acid-fast bacteria. AA-57 was discovered by screening actinomycete cultures for antibacterial properties. AA-57 exhibits significant antibacterial activity and has inhibitory effects against a variety of bacteria.

HY-138288

threo-6'-Hydroxyustusolate C	Others	Others
threo-6'-Hydroxyustusolate C is an ustusolic acid ester that can be isolated from the fermentation broth of the mangrove-derived fungus Aspergillus ustus 094102 .

HY-119736

Leptolstatin	Others	Others
Leptolstatin is an inhibitor of the progression of G1 and G2 phases of the mammalian cell cycle. Leptolstatin can be extracted from the fermentation broth of Streptomyces sp. SAM1595 .

HY-N17826

YM-254891	Drug Derivative Bacterial P2Y Receptor Endogenous Metabolite	Cardiovascular Disease
YM-254891 is a YM-254890 (HY-111557) analogue and Gαq/11 inhibitor. YM-254891 can be isolated from the fermentation broth of Chromobacterium sp. QS3666. YM-254891 inhibits ADP-induced platelet aggregation .

HY-182630

CJ-14897	Interleukin Related TNF Receptor	Inflammation/Immunology
CJ-14897 is a cytokine production inhibitor, with IC₅₀ values of 0.059 μM and 0.59 μM for IL-1β and TNF-α production, respectively, and an IC₅₀ of 180 μM for leucine uptake. CJ-14897 is isolated from the fermentation broth of the basidiomycete Marasmius strain CL21624 .

HY-P11751A

RES-701-3 peptide TFA	Endogenous Metabolite Endothelin Receptor	Cardiovascular Disease Infection
RES-701-3 peptide TFA is a class II lasso peptide. RES-701-3 peptide TFA can be isolated from the fermentation broth of Streptomyces species. RES-701-3 peptide TFA potently inhibits the binding of ET-1 to ET_B, with an IC₅₀ of approximately 5-10 nM. RES-701-3 peptide TFA is applicable to research related to systemic hypertension, myocardial infarction, and myocardial ischemia .

HY-N6189

MBL-1	Endogenous Metabolite COX p38 MAPK NF-κB NOD-like Receptor (NLR) NO Synthase Reactive Oxygen Species (ROS) Interleukin Related	Infection Inflammation/Immunology
MBL-1 is an orally active anti-inflammatory agent. MBL-1 can be isolated from the fermentation broth of Aspergillus sp. derived from gorgonians. MBL-1 inhibits the activity of the hCOX-2 protein with an IC₅₀ of 5.77 μM. MBL-1 reduces the production of key pro-inflammatory mediators such as NO, ROS, IL-1β and IL-18 by inhibiting the MAPK/NF-κB and NLRP3 signaling pathways. MBL-1 exerts a protective effect against DSS-induced colitis. MBL-1 can be used for the research of ulcerative colitis .

HY-W450115

USF 2550A	Reactive Oxygen Species (ROS)	Inflammation/Immunology
USF 2550A is a class of fungus-derived 2-pyran compound with DPPH free radical scavenging activity. USF 2550A binds to DPPH free radicals in organic solvents to form adducts, thereby achieving free radical scavenging; in acetate buffer, the formed adducts undergo degradation, and the degradation products can continuously scavenge free radicals. USF 2550A can be used in antioxidant-related research .

Indole-2-carbaldehyde	Biochemical Assay Reagents
Indole-2-carbaldehyde is an indole derivative that can be used to reduce or remove localized fat deposits and/or tighten loose skin and soft tissues. Indole-2-carbaldehyde can be isolated from the fermentation broth of the coral symbiotic actinomycete Pseudonocardia sp. SCSIO 11457 and is used in cosmetic applications or pharmaceutical production .

Cat. No.	Product Name	Target	Research Area

HY-148209

Balhimycin	Antibiotic Bacterial	Infection
Balhimycin is a glycopeptide antibiotic, found from the fermentation broth of a Amycolatopsis sp. Balhimycin shows anti-bacterial activity against staphylococci and anaerobes .

HY-P11751A

RES-701-3 peptide TFA	Endogenous Metabolite Endothelin Receptor	Cardiovascular Disease Infection
RES-701-3 peptide TFA is a class II lasso peptide. RES-701-3 peptide TFA can be isolated from the fermentation broth of Streptomyces species. RES-701-3 peptide TFA potently inhibits the binding of ET-1 to ET_B, with an IC₅₀ of approximately 5-10 nM. RES-701-3 peptide TFA is applicable to research related to systemic hypertension, myocardial infarction, and myocardial ischemia .

3,4-Dimethoxyphenol	Monophenols Microorganisms Classification of Application Fields Phenols Metabolic Disease Cosmetic Research Disease Research Fields Source Classification	Tyrosinase Bacterial
3,4-Dimethoxyphenol is a plant-derived phenylpropanoid compound and can use as a whitening agent in cosmetics. 3,4-Dimethoxyphenol exhibits broad-spectrum antimicrobial activity. 3,4-Dimethoxyphenol has tyrosinase-inhibiting activity. 3,4-Dimethoxyphenol has potent antioxidant effect isolated from the bacterial fermentation broth. 3,4-Dimethoxyphenol can be used for the study of infection .

AB 3217-A Antibiotic AB3217A	Microorganisms Antibiotics Other Antibiotics Source Classification	Parasite
AB 3217-A, an anti-mite substance, can be isolated from the fermentation broth of a streptomycete strain .

Plicacetin	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic
Plicacetin is a crystalline antibiotic isolated from the fermentation broth of Streptomyces actinomycetes and is structurally similar to Amicetin (HY-120383) and Bamicetin. .

Cephalonic acid	Other Terpenoids Microorganisms Terpenoids Source Classification	Bacterial
Cephalonic acid is a pentaprenyl terpenoid compound that can be isolated from the fermentation broth of Cephaloscorlum caerulens. Cephalonic acid has weak antibacterial activity against Staphylococcus aureus .

3,4-Dimethoxytropolone	Natural Products Microorganisms Source Classification	Bacterial
3,4-Dimethoxytropolone can be isolated from Streptoverticillium hadanonense fermentation broths and found to be active against both Gram-positive and Gram-negative bacteria .

Catenulopyrizomicin A	Alkaloids Microorganisms Pyridine Alkaloids Source Classification	HBV
Catenulopyrizomicin A has a thiazolyl pyridine moiety. Catenulopyrizomicin A can be isolated from the fermentation broth of rare actinomycete Catenuloplanes sp. Catenulopyrizomicin A has anti-Hepatitis B virus activity .

Nanaomycin αA OM173-αA; Nanaomycin A methyl ester	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Phenols Disease Research Fields Source Classification	Antibiotic
Nanaomycin αA (OM173-αA) is an antibiotic with antimicrobial activity. Nanaomycin αA can be isolated from a fermentation broth of Streptomyces hebeiensis derived from lichen .

Cyclo(Ala-Tyr)	Alkaloids Microorganisms Other Alkaloids Source Classification	Others
Cyclo(Ala-Tyr) is a cyclic dipeptide that can be isolated from the fermentation broth of the marine microorganism Bacillus marinus B-9987 isolated from the rhizosphere tissue of Suaeda salsa in the intertidal zone of Bohai Bay, China .

AS-2077715	Microorganisms Antibiotics Other Antibiotics Source Classification	Fungal Antibiotic
AS-2077715 is an antifungal agent that shows inhibitory activity against the Trichophyton species. AS-2077715 can be obtained from the fermentation broth of Capnodium sp. 339855. AS-2077715 can be used to study fungal infections .

Deoxyfrenolicin	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Deoxyfrenolicin is a quinone antibiotic that can be isolated from the fermentation broth of the Streptomyces roseofulvus strain AM-3867. Deoxyfrenolicin belongs to the frenolicin class of antibiotics. Deoxyfrenolicin exhibits antibacterial activity in vitro and can effectively inhibit the activity of Mycoplasma gallisepticum .

Dihydrotetrodecamycin	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Dihydrotetrodecamycin is an antibiotic that can be isolated from the fermentation broth of Streptomyces nashvillensis MJ885-mF8. Dihydrotetrodecamycin has MIC values of 50 mg/mL against both Pasteurella piscicida sp. 639 and P. piscicida sp. 6356 .

3,4-Dimethoxyphenol (Standard)	Structural Classification Monophenols Microorganisms Phenols Source Classification	Reference Standards Tyrosinase Bacterial
3,4-Dimethoxyphenol (Standard) is the analytical standard of Lithocholic acid. This product is intended for research and analytical applications. 3,4-Dimethoxyphenol is a plant-derived phenylpropanoid compound and can use as a whitening agent in cosmetics. 3,4-Dimethoxyphenol exhibits broad-spectrum antimicrobial activity. 3,4-Dimethoxyphenol has tyrosinase-inhibiting activity. 3,4-Dimethoxyphenol has potent antioxidant effect isolated from the bacterial fermentation broth. 3,4-Dimethoxyphenol can be used for the study of infection .

AA-57	Structural Classification Natural Products Microorganisms Source Classification	Antibiotic
AA-57 is an acidic lipophilic antibiotic isolated from the fermentation broth of Actinomycetes strain AA-57. The AA-57 strain can be isolated from a soil sample collected in Koriyama City, Fukushima Prefecture, Japan. AA-57 has antibacterial properties against Gram-positive bacteria, Gram-negative bacteria, and acid-fast bacteria. AA-57 was discovered by screening actinomycete cultures for antibacterial properties. AA-57 exhibits significant antibacterial activity and has inhibitory effects against a variety of bacteria.

threo-6'-Hydroxyustusolate C	Structural Classification Natural Products Microorganisms Ketones, Aldehydes, Acids Source Classification	Others
threo-6'-Hydroxyustusolate C is an ustusolic acid ester that can be isolated from the fermentation broth of the mangrove-derived fungus Aspergillus ustus 094102 .

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fermentation broth

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Biochemical Assay Reagents

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