258871-59-9
Chemical Structure
PF-1163A
- CAS No.: 258871-59-9
- Formula:C27H43NO6
- Molecular Weight:477.63
IUPAC Name: (3S,10R,13S)-3-(4-(2-hydroxyethoxy)benzyl)-13-((S)-2-hydroxypentyl)-4,10-dimethyl-1-oxa-4-azacyclotridecane-2,5-dione
InChIKey: SDBGPLZSWIQIOV-VQPAQMSKSA-N
SMILES: O=C(O[C@@H](CC[C@@H](CCCCC(N1C)=O)C)C[C@@H](O)CCC)[C@@H]1CC2=CC=C(C=C2)OCCO
Biological Activity: PF-1163A is an antifungal agent that inhibits Ergosterol (HY-N0181) synthesis (IC50 = 12 ng/mL), which is found in a fermentation broth of Penicillium sp. PF-1163A also inhibits C-4 sterol methyl oxidase with an MIC value of 12.5 µg/mL[1][2].
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PF-1163A | PF-1163A is an antifungal agent that inhibits Ergosterol (HY-N0181) synthesis (IC50 = 12 ng/mL), which is found in a fermentation broth of Penicillium sp. PF-1163A also inhibits C-4 sterol methyl oxidase with an MIC value of 12.5 µg/mL. | |||||||||||||||||||||
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- [1]. Nose H, et al. PF1163A, a novel antifungal agent, inhibit ergosterol biosynthesis at C-4 sterol methyl oxidase. J Antibiot (Tokyo). 2002 Nov;55(11):969-74. [Content Brief]
- [2]. Okabe M, et al. Macrolides from a Marine-Derived Fungus, Penicillium meleagrinum var. viridiflavum, Showing Synergistic Effects with Fluconazole against Azole-Resistant Candida albicans. J Nat Prod. 2016 Apr 22;79(4):1208-12. [Content Brief]
Keywords
