Macrolides from a Marine-Derived Fungus, Penicillium meleagrinum var. viridiflavum, Showing Synergistic Effects with Fluconazole against Azole-Resistant Candida albicans

  • J Nat Prod. 2016 Apr 22;79(4):1208-12. doi: 10.1021/acs.jnatprod.6b00019.
Miki Okabe  1 ,  Takashi Sugita  1 ,  Kaoru Kinoshita  1 ,  Kiyotaka Koyama  1
Affiliations
  • 1. Department of Pharmacognosy and Phytochemistry and ‡Department of Microbiology, Meiji Pharmaceutical University , 2-522-1 Noshio, Kiyose-shi, Tokyo 204-8588, Japan.
PMID: 27014845 DOI: 10.1021/acs.jnatprod.6b00019
Abstract

Two new 13-membered macrolides (1, 7), along with known 13-membered macrolides PF1163A, B, D, H, and F (2-6), were isolated from a strain of a marine-derived fungus, Penicillium meleagrinum var. viridiflavum. The structures of 1 and 7 were elucidated from spectroscopic data (NMR, MS, IR). Compounds 1-7 showed synergistic effects with fluconazole against azole-resistant Candida albicans by a checkerboard assay.

Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-123457
    PF-1163A
    Antifungal Agent/C-4 Sterol Methyl Oxidase Inhibitor
    target: Fungal
    Research Areas: Infection