Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
24 Results for "
fluorescence polarization
" in MedChemExpress (MCE) Product Catalog:
Products (24)
24 Results for "fluorescence polarization" in MCE Product Catalog:
11
11 Publications Verification
Cat. No.: HY-D0986
CAS No.: 115534-33-3
6
Target:
Research Areas:
Lissamine rhodamine B is a red-fluorescent dye, it is a derivative of rhodamine. Lissamine rhodamine B can be used as a fluorescent probe to develop competitive aptamer fluorescence anisotropy/polarization (FA/FP) assays .
3
3 Cited Publications
Target:
Research Areas:
hPGDS-IN-1 (Compound 2 ) is an hPGDS inhibitor with an IC50 of 12 nM (as measured by fluorescence polarization assay or EIA). hPGDS-IN-1 can be used in the research of allergic rhinitis and spinal cord neurons .
1
1 Cited Publications
Cat. No.: HY-175686
Target:
Research Areas:
E3 ligase Ligand 67 (Compound 5) is a STUB1/CHIP ligand with a Kd of 8.9 μM for CHIP in fluorescence polarization assay. E3 ligase Ligand 67 is an E3 ligase ligand that can be used for synthesis of PROTACs .
Cat. No.: HY-DY1057
CAS No.: 115534-33-3
Solvent and concentration: DMSO: 10 mM
Cat. No.: HY-163385
Target:
Research Areas:
ALKBH1-IN-1 (Compound 13h) is a selective ALKBH1 inhibitor, with an IC50 of 0.026 μM and 1.39 μM in the fluorescence polarization and enzyme activity assay, respectively. ALKBH1-IN-1 can modulate the level of DNA 6mA modifications. ALKBH1-IN-1 can be used to study the functions of ALKBH1 and DNA 6mA .
Cat. No.: HY-P5908F
Cat. No.: HY-W013967
CAS No.: 1720-32-7
Target:
Research Areas:
TDRL-X80 is a potent inhibitor of xeroderma pigmentosum group A (XPA) protein. TDRL-X80 inhibits XPA’s DNA binding activity. TDRL-X80 exhibits activity against single, double, and Cisplatin-damaged DNA with IC50s of 18, 20, and 29 μM in fluorescence polarization (FP) analyses , and with IC50s of 21, 39, and 28 in ELISA Analysis .
Cat. No.: HY-12577
CAS No.: 1498300-31-4
TNKS1/2-IN-1 (Example 4) is a TNKS1 and TNKS2 inhibitor, with pIC50 values of 8.2 or 7.3 against TNKS1, and 7.1 or 7.7 against TNKS2. TNKS1/2-IN-1 inhibits the enzymatic activities of TNKS1 and TNKS2. TNKS1/2-IN-1 is applicable for cancer research .
Cat. No.: HY-175250
Target:
Research Areas:
TNF-α-IN-25 is an orally active TNF-α inhibitor. TNF-α-IN-25 shows Fluorescence Polarization (FP) assay IC50 of 103 nM in FP binding assays and L929 assay IC50 of 505 nM in cell-based assays. TNF-α-IN-25 inhibits paw swelling in the glucose-6-phosphate isomerase (GPI) arthritis model. TNF-α-IN-25 can be used for the study of arthritis .
Cat. No.: HY-P5909F
Target:
Research Areas:
Cat. No.: HY-D2898
Cat. No.: HY-D2931
CAS No.: 1154528-97-8
Cat. No.: HY-D1349
CAS No.: 2006345-35-1
Cat. No.: HY-117983
CAS No.: 1314206-29-5
Target:
Research Areas:
RU-505 is an effective β-amyloid (Aβ)-fibrinogen interaction inhibitor with IC50s of 5.00 and 2.72 μM in fluorescence polarization (FP) and AlphaLISA assays, respectively. RU-505 is highly permeable to the BBB. RU-505 reduces cerebral amyloid angiopathy (CAA). RU-505 can be used for the research of Alzheimer’s disease (AD) .
Cat. No.: HY-146578
CAS No.: 2769963-54-2
Target:
Research Areas:
Keap1-Nrf2-IN-8 (compound 12d) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with IC50s of 64.5 nM and 14.2 nM for FP and TR-FRET assays, respectively. Keap1-Nrf2-IN-8 significantly increases the mRNA levels of Nrf2 downstream genes, GSTM3, HMOX2 and NQO1 .
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
