2769963-54-2
2769963-54-2
Chemical Structure
Keap1-Nrf2-IN-8
- CAS No.: 2769963-54-2
- Formula:C35H31FN2O9S2
- Molecular Weight:706.76
IUPAC Name: 2,2'-((2-((4-fluorobenzyl)oxy)naphthalene-1,4-diyl)bis(tosylazanediyl))diacetic acid
InChIKey: FXADTNLKEANMJS-UHFFFAOYSA-N
SMILES: CC1=CC=C(C=C1)S(=O)(N(C2=C3C=CC=CC3=C(C(OCC4=CC=C(C=C4)F)=C2)N(S(=O)(C5=CC=C(C=C5)C)=O)CC(O)=O)CC(O)=O)=O
Biological Activity: Keap1-Nrf2-IN-8 (compound 12d) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with IC50s of 64.5 nM and 14.2 nM for FP and TR-FRET assays, respectively. Keap1-Nrf2-IN-8 significantly increases the mRNA levels of Nrf2 downstream genes, GSTM3, HMOX2 and NQO1[1].
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Keap1-Nrf2-IN-8 | Keap1-Nrf2-IN-8 (compound 12d) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with IC50s of 64.5 nM and 14.2 nM for FP and TR-FRET assays, respectively. Keap1-Nrf2-IN-8 significantly increases the mRNA levels of Nrf2 downstream genes, GSTM3, HMOX2 and NQO1. | |||||||||||||||||||||
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