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Pathways Recommended:	MAPK/ERK Pathway

Results for "

formyl peptide receptor pathway

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Formyl Peptide Receptor (FPR) (3) Arrestin (1) Interleukin Related (1) PKA (1) Reactive Oxygen Species (ROS) (1)
By Research Areas:	Cardiovascular Disease (1) Inflammation/Immunology (1) Neurological Disease (1)

Inhibitors & Agonists

Peptides

Targets Recommended: Formyl Peptide Receptor (FPR) Tissue Factor Pathway Inhibitor (TFPI) RXFP Receptor Peptide-Drug Conjugates (PDCs) Natriuretic Peptide Receptor (NPR) Connective Peptide CGRP Receptor Amyloid-β

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-172435

Rezuforimod AGN-232411; AG-80308; AGN-411	Formyl Peptide Receptor (FPR)	Neurological Disease
Rezuforimod (AGN-232411; AG-80308) is an ophthalmic solution targeting the formyl peptide receptor (FPR) pathway. Rezuforimod exerts anti-inflammatory effects by targeting the formyl peptide receptor pathway. Administered topically, Rezuforimod significantly reduces the corneal conjunctival staining score and improves ocular discomfort symptoms, with no serious adverse events reported and favorable overall safety profile. Rezuforimod shows remarkable potential to serve as a novel therapeutic option for dry eye disease .

HY-P11491

Ac2-26 (mouse)	Formyl Peptide Receptor (FPR) Reactive Oxygen Species (ROS)	Inflammation/Immunology
Ac2-26 (mouse) is the N-terminal active peptide of Annexin A1 (AnxA1). Ac2-26 (mouse) regulates the inflammatory response by modulating the **formyl peptide receptor (FPR*) signaling pathway. Ac2-26 (mouse) can promote the release of chemokines and inhibit the production of ROS*. Ac2-26 (mouse) can be used for the research of inflammation, such as rheumatoid arthritis .

HY-181822

BMS-986331	Formyl Peptide Receptor (FPR) Arrestin PKA Interleukin Related	Cardiovascular Disease
BMS-986331 is an orally active selective *N-Formyl* Peptide Receptor 2 (FPR2) agonist with an EC₅₀ of 0.5 nM in humans and 1 nM in rats. BMS-986331 activates Gαi2, GαoA, Gα12, Gα13** signaling pathways, recruits β-arrestin1 and β-arrestin2, and inhibits downstream cAMP. BMS-986331 induces the expression and release of the pro-resolution cytokine IL-10. BMS-986331 improves cardiac structure and function in a rat model of heart failure induced by permanent coronary artery occlusion. BMS-986331 can be used for the research of heart failure .

Cat. No.	Product Name	Target	Research Area

HY-P11491

Ac2-26 (mouse)	Formyl Peptide Receptor (FPR) Reactive Oxygen Species (ROS)	Inflammation/Immunology
Ac2-26 (mouse) is the N-terminal active peptide of Annexin A1 (AnxA1). Ac2-26 (mouse) regulates the inflammatory response by modulating the **formyl peptide receptor (FPR*) signaling pathway. Ac2-26 (mouse) can promote the release of chemokines and inhibit the production of ROS*. Ac2-26 (mouse) can be used for the research of inflammation, such as rheumatoid arthritis .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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