Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
hTRPV1 channel
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "hTRPV1 channel" in MCE Product Catalog:
Cat. No.: HY-16935
CAS No.: 956274-94-5
Synonyms: JNJ-39439335
Target:
Research Areas:
Mavatrep (JNJ-39439335) is an orally active, selective and potent TRPV1 antagonist with high affinity for hTRPV1 channels (Ki=6.5 nM). Mavatrep antagonizes capsaicin-induced Ca 2+ influx with an IC50 value of 4.6 nM. Mavatrep can be used in some studies of neuropathic pain .
Cat. No.: HY-16935S
Synonyms: JNJ-39439335-d6
Cat. No.: HY-183281
Target:
Research Areas:
TRPV3 antagonist-1 is a selective TRPV3 channel antagonist with an IC50 of 11.97 μM. TRPV3 antagonist-1 shows selectivity over hTRPV1, hTRPV4, hTRPA1, and hTRPM8. TRPV3 antagonist-1 shows low cytotoxicity .
Cat. No.: HY-16935R
CAS No.: 956274-94-5
Synonyms: JNJ-39439335 (Standard)
Target:
Research Areas:
Mavatrep (Standard) is the analytical standard of Mavatrep. This product is intended for research and analytical applications. Mavatrep (JNJ-39439335) is an orally active, selective and potent TRPV1 antagonist with high affinity for hTRPV1 channels (Ki=6.5 nM). Mavatrep antagonizes capsaicin-induced Ca2+ influx with an IC50 value of 4.6 nM. Mavatrep can be used in some studies of neuropathic pain .
Cat. No.: HY-175980
CAS No.: 3083086-77-2
Target:
Research Areas:
TRPA1 agonist-3 is a selective and orally active TRPA1 agonist, with EC50 values of 50.05 μM and 314.04 μM for human and mouse TRPA1, respectively. TRPA1 agonist-3 does not activate hTRPV1, mTRPV2, hTRPV3, hTRPV4, hTRPC6, or hTRPM8 channels. TRPA1 agonist-3 alleviates inflammatory pain in mice through a channel desensitization mechanism .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
