3083086-77-2
3083086-77-2
Chemical Structure
TRPA1 agonist-3
- CAS No.: 3083086-77-2
- Formula:C14H18N2OS
- Molecular Weight:262.37
InChIKey: RKESFIUFZSXDFU-UHFFFAOYSA-N
SMILES: COCCCNC1=NC(C2=CC=C(C=C2)C)=CS1
Biological Activity: TRPA1 agonist-3 is a selective and orally active TRPA1 agonist, with EC50 values of 50.05 μM and 314.04 μM for human and mouse TRPA1, respectively. TRPA1 agonist-3 does not activate hTRPV1, mTRPV2, hTRPV3, hTRPV4, hTRPC6, or hTRPM8 channels. TRPA1 agonist-3 alleviates inflammatory pain in mice through a channel desensitization mechanism[1].
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TRPA1 agonist-3 | 99.78% | TRPA1 agonist-3 is a selective and orally active TRPA1 agonist, with EC50 values of 50.05 μM and 314.04 μM for human and mouse TRPA1, respectively. TRPA1 agonist-3 does not activate hTRPV1, mTRPV2, hTRPV3, hTRPV4, hTRPC6, or hTRPM8 channels. TRPA1 agonist-3 alleviates inflammatory pain in mice through a channel desensitization mechanism. | ||||||||||||||||||||
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References
Keywords
