4 Results for "

hippocampal tau levels

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "hippocampal tau levels" in MCE Product Catalog:

1
Schisantherin B
Schisantherin B
0 Images
1 Cited Publications
Cat. No.: HY-N0695
CAS No.: 58546-55-7
Synonyms: Gomisin-B; Wuweizi ester-B; Schisantherin-B
Category:  

Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Inflammation/Immunology Schisandra chinensis (Turcz.) Baill.

Target:  

PI3K Akt mTOR GSK-3 Tau Protein TNF Receptor Interleukin Related Apoptosis

Schisantherin B (Gomisin-B) is a lignan compound and one of the active components of Schisandra chinensis. Schisantherin B activates the PI3K/AKT signaling pathway, restores the activity of GSK3β, and reduces the hyperphosphorylation of tau protein in hippocampal and cerebral cortical tissues. Schisantherin B upregulates the level of GLT-1, decreases the expression of pro-inflammatory cytokines TNF-α/IL-1β/IL-6, upregulates the expression of IL-10, and inhibits cell apoptosis. Schisantherin B is applicable to the research of spinal cord injury, Alzheimer's disease and depression .
loading...
    loading...
View All Sizes
OX-201
OX-201
0 Images
Cat. No.: HY-162712
CAS No.: 2460722-03-4
Target:  

Orexin Receptor (OX Receptor) Tau Protein

Research Areas:  

Neurological Disease

OX-201 is an orally active, blood-brain barrier-permeable OX2R agonist with an EC50 of 8.0 nM. OX-201 activates OX2R to induce wakefulness and neuronal activation. OX-201 promotes the release of neuron activity-dependent tau protein from neurons into the interstitial fluid of hippocampal tissues. OX-201 is applicable to research related to Alzheimer's disease and tauopathies .
loading...
    loading...
View All Sizes
Schisantherin B (Standard)
Schisantherin B (Standard)
0 Images
Cat. No.: HY-N0695R
CAS No.: 58546-55-7
Synonyms: Gomisin-B (Standard); Wuweizi ester-B (Standard); Schisantherin-B (Standard)
Category:  

Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill.

Target:  

Reference Standards PI3K Akt mTOR GSK-3 Tau Protein TNF Receptor Interleukin Related Apoptosis

Schisantherin B (Gomisin-B) (Standard) is the analytical standard of Schisantherin B. This product is intended for research and analytical applications. Schisantherin B is a lignan compound and one of the active components of Schisandra chinensis. Schisantherin B activates the PI3K/AKT signaling pathway, restores the activity of GSK3β, and reduces the hyperphosphorylation of tau protein in hippocampal and cerebral cortical tissues. Schisantherin B upregulates the level of GLT-1, decreases the expression of pro-inflammatory cytokines TNF-α/IL-1β/IL-6, upregulates the expression of IL-10, and inhibits cell apoptosis. Schisantherin B is applicable to the research of spinal cord injury, Alzheimer's disease and depression.
loading...
    loading...
View All Sizes
AJ-4
AJ-4
0 Images
Cat. No.: HY-184742
Target:  

GSK-3 Cholinesterase (ChE) Amyloid-β Tau Protein

Research Areas:  

Neurological Disease

AJ-4 is an orally active, blood-brain barrier-permeable GSK-3β/AChE inhibitor, with an IC50 of 4.7 nM against GSK-3β and 2.97 μM against AChE. AJ-4 increases the level of phosphorylated GSK-3β and reduces the expression of Amyloid-β and phosphorylated Tau. AJ-4 improves scopolamine-induced learning and memory impairment and alleviates hippocampal neuron damage in AD mice. AJ-4 can be used for the research of Alzheimer's disease .
loading...
    loading...
View All Sizes
Assay Types