173 Results for "

immunoglobulin G

" in MedChemExpress (MCE) Product Catalog:
Products (173)

173 Results for "immunoglobulin G" in MCE Product Catalog:

36
36 Publications Verification
Cat. No.: HY-K0230

MCE Protein A/G Agarose is an affinity chromatography medium for separation and purification of immunoglobulins.

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13
13 Cited Publications
Cat. No.: HY-127105
CAS No.: 1644670-37-0
Purity:  99.93%
Synonyms: LNP023
Iptacopan (LNP023) is an effective and orally-active highly selective factor B inhibitor with an IC50 value of 10 nM and KD of 7.9 nM. Iptacopan exerts a proximal effect in the complement cascade reaction, preventing the destruction (hemolysis) of red blood cells in PNH and the damage of renal cells in IgAN and C3G. Iptacopan can be used for the study of complement-mediated diseases, particularly paroxysmal nocturnal hemoglobinuria (PNH), primary immunoglobulin A nephropathy (IgAN), and complement 3 glomerulopathy (C3G) .
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13
13 Cited Publications
Cat. No.: HY-127105A
CAS No.: 1646321-63-2
Purity:  99.83%
Synonyms: LNP023 hydrochloride
Iptacopan (LNP023) hydrochloride is an effective and orally-active highly selective factor B inhibitor with an IC50 value of 10 nM and KD of 7.9 nM. Iptacopan hydrochloride exerts a proximal effect in the complement cascade reaction, preventing the destruction (hemolysis) of red blood cells in PNH and the damage of renal cells in IgAN and C3G. Iptacopan hydrochloride can be used for the study of complement-mediated diseases, particularly paroxysmal nocturnal hemoglobinuria (PNH), primary immunoglobulin A nephropathy (IgAN), and complement 3 glomerulopathy (C3G) .
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5
5 Cited Publications
Cat. No.: HY-P990679

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology Cancer

Rat IgG2a kappa, Isotype Control is a monoclonal antibody derived from rats, representing the immunoglobulin G2a (IgG2a) subclass with a kappa light chain. Rat IgG2a kappa, Isotype Control exhibits high efficiency in inducing K cell mediated cytotoxicity. Rat IgG2a kappa, Isotype Control is utilized in research investigating the roles of different immunoglobulin subclasses in tumor immunology. Rat IgG2a kappa, an isotype control, can be used as an isotype control for Anti-Mouse PD-1 Antibody (RMP1-14) (HY-P99144), Anti-Mouse CD11a/LFA-1α Antibody (M17/4) (HY-P990801), and Anti-Mouse IL-2 Antibody (S4B6-1) (HY-P990796) .
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2
2 Cited Publications
Cat. No.: HY-P99550
CAS No.: 2376858-66-9
Synonyms: MEDI-3506

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Tozorakimab (MEDI-3506) is a human immunoglobulin G1 monoclonal antibody targeting interleukin-33. Tozorakimab reduces inflammation and epithelial dysfunction. Tozorakimab can be used to research chronic obstructive pulmonary disease .
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2
2 Cited Publications
Cat. No.: HY-103358
CAS No.: 257292-29-8
Purity:  99.63%
Target:  

P-selectin

Research Areas:  

Inflammation/Immunology

KF38789 is a selective inhibitor of P-selectin-PSGL-1 binding. KF38789 inhibits the binding of U937 cells to immobilized P-selectin immunoglobulin G chimeric protein (P-selectin-Ig) with an IC50 value of 1.97 μM .
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1
1 Cited Publications
Cat. No.: HY-P99033
CAS No.: 1905409-39-3
Synonyms: BTCT-4465A; RG-7828; RO7030816

Target:  

CD20 CD3

Research Areas:  

Inflammation/Immunology Cancer

Mosunetuzumab (BTCT-4465A) is a full-length, fully humanized immunoglobulin G1 (IgG1) T-cell-dependent bispecific (TDB) antibody targeting CD20 (B cells) and CD3 (T cells). Mosunetuzumab redirects T cells to engage and eliminate malignant B cells and can be used for the research of relapsed or refractory (R/R) B-cell non-Hodgkin lymphomas (B-NHLs) .
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1
1 Cited Publications
Cat. No.: HY-P9920A
CAS No.: 947687-13-0

Target:  

VEGFR

Research Areas:  

Cancer

Ramucirumab (anti-VEGFR) is a human VEGFR-2 antagonist for the treatment of solid tumors. Ramucirumab (anti-VEGFR) is a recombinant human immunoglobulin G1 monoclonal antibody that binds to the extracellular binding domain of VEGFR-2 and prevents the binding of VEGFR ligands: VEGF-A, VEGF-C, and VEGF-D. Ramucirumab (anti-VEGFR) is also an angiogenesis inhibitor .
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1
1 Cited Publications
Cat. No.: HY-P99934
CAS No.: 1820660-69-2
Synonyms: ABBV-621

Research Areas:  

Cancer

Eftozanermin alfa (ABBV-621) is a tumor necrosis factor-related apoptosis-inducing ligand receptor (TRAIL-R) agonist. Eftozanermin alfa is a fusion protein consisting of a mutant immunoglobulin G1-Fc linked to 2 single-chain trimers of TRAIL. Eftozanermin alfa induces apoptosis in tumor cells by activation of death receptors (DR4 receptor and DR5 receptor) with Kds of 780 nM and 635 nM. Eftozanermin alfa can be used for the research of multiple solid and heme malignancies .
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1
1 Cited Publications
Cat. No.: HY-P81005

Host:  

Goat

Application:  

ICC/IF, IF-Tissue, FC

Reactivity:  

Rabbit

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1
1 Cited Publications
Cat. No.: HY-P70771
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IGHG4; immunoglobulin Heavy Constant Gamma 4; immunoglobulin Heavy Constant Gamma 4 (G4m Marker); Ig Gamma-4 Chain C Region; immunoglobulin Heavy Chain Constant Region Gamma 4
Species:  
Human
Source:  
HEK293
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1
1 Cited Publications
Cat. No.: HY-P73143
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IGHG1; Ig Gamma-1 Chain C Region NIE; immunoglobulin Heavy Constant Gamma 1 (G1m Marker); Ig Gamma-1 Chain C Region KOL; Constant Region Of Heavy Chain Of IgG1; Ig Gamma-1 Chain C Region EU; immunoglobulin Heavy Constant Gamma 1; Ig Gamma-1 Chain C Region
Species:  
Human
Source:  
HEK293
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1
1 Cited Publications
Cat. No.: HY-P70796
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IGHG1; Ig Gamma-1 Chain C Region NIE; immunoglobulin Heavy Constant Gamma 1 (G1m Marker); Ig Gamma-1 Chain C Region KOL; Constant Region Of Heavy Chain Of IgG1; Ig Gamma-1 Chain C Region EU; immunoglobulin Heavy Constant Gamma 1; Ig Gamma-1 Chain C Region
Species:  
Human
Source:  
HEK293
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1
1 Cited Publications
Cat. No.: HY-P70705
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FCGR3A; CD16; Prev. FCGR3; Fc Fragment Of IgG, Low Affinity IIIa, Receptor For (CD16); Prev. FCG3; Fc Of IgG Low Affinity IIIa Receptor Isoform 2; FcgammaRIIIa; Fc Of IgG Low Affinity IIIa Receptor Isoform 1; FcGRIIIA; immunoglobulin G Fc Receptor III; CD
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P99367
CAS No.: 2484870-90-6
Synonyms: DS-7300a Antibody; MABX-9001A Antibody

Target:  

CD276/B7-H3

Research Areas:  

Inflammation/Immunology Cancer

Ifinatamab is monoclonal immunoglobulin G1-kappa with anti-human B7 homolog 3 protein (Human B7-H3). Ifinatamab is a glycoforme α immunomodulateur .
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Cat. No.: HY-P99955
CAS No.: 2431972-52-8
Synonyms: AMG 451; KHK4083
Rocatinlimab (AMG 451) (KHK4083) is a fully human immunoglobulin G1 (IgG1) anti-OX40 monoclonal antibody. Rocatinlimab can be used for the research of atopic dermatitis (AD) .
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Cat. No.: HY-147305
CAS No.: 1821402-21-4
Synonyms: ARGX-113
Efgartigimod alfa (ARGX-113) is a reversibility, humanized Fc receptor antagonist . Efgartigimod alfa is a anti FcRn monoclonal immunoglobulin G (IgG1) Fc fragment. Efgartigimod reduces serum levels of total IgG, including pathogenic autoantibodies, by blocking FcRn function without permanent impairment. Efgartigimod alfa can be used for generalised myasthenia gravis (gMG) and primary immune thrombocytopenia research .
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Cat. No.: HY-P99521
CAS No.: 2138442-13-2
Synonyms: XmAb14045

Target:  

CD3

Research Areas:  

Inflammation/Immunology Cancer

Vibecotamab (XmAb14045) is a potent bispecific antibody targeting both CD123 and CD3. Vibecotamab targets T cell-mediated killing of CD123-expressing cells, regardless of T cell antigen specificity. Vibecotamab is a full length immunoglobulin molecule. Vibecotamab can be studied in research for diseases such as Myelodysplastic syndrome and acute myeloid leukemia. Recommend Isotype Control: half-IG G1-kappa/(scFv-heavy-lambda)-h-CH2-CH3 .
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Cat. No.: HY-P990047
CAS No.: 2761478-99-1
Synonyms: AMG133 antibody

Research Areas:  

Metabolic Disease

Maridebart (AMG133 antibody) is a human immunoglobulin G1-kappa, anti-GIPR (gastric inhibitory polypeptide receptor) monoclonal antibody. Maridebart is the antibody portion of Maridebart cafraglutide (HY-164535) and can be used for the synthesis of antibody-drug conjugates (ADC). Maridebart can be used for the reserrch of obesity and type 2 diabetes .
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Cat. No.: HY-P99036
CAS No.: 1296818-77-3

Target:  

Tie

Nesvacumab is a fully human immunoglobulin G1 (IgG1) monoclonal antibody that specifically binds and inactivates the Tie2 receptor ligand Angiopoietin-2 (Ang2) with high affinity, but shows no binding to Ang1. Nesvacumab can be used in vascular researches .
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