71 Results for "

initial

" in MedChemExpress (MCE) Product Catalog:
Products (71)

71 Results for "initial" in MCE Product Catalog:

15
15 Publications Verification
Cat. No.: HY-B0317
CAS No.: 88150-42-9
Target:  

Calcium Channel

Research Areas:  

Cardiovascular Disease Cancer

Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer .
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15
15 Publications Verification
Cat. No.: HY-B0317B
CAS No.: 111470-99-6
Synonyms: Amlodipine benzenesulfonate
Target:  

Calcium Channel

Research Areas:  

Cardiovascular Disease Cancer

Amlodipine besylate (Amlodipine benzenesulfonate), an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine besylate can be used for the research of high blood pressure and cancer .
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15
15 Publications Verification
Cat. No.: HY-B0317A
CAS No.: 88150-47-4
Target:  

Calcium Channel

Research Areas:  

Cardiovascular Disease Cancer

Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer .
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4
4 Cited Publications
Cat. No.: HY-144776
CAS No.: 831243-31-3
Purity:  99.85%
Target:  

NAMPT

Research Areas:  

Cancer

NAT is an initial hit of NAMPT activator with an EC50 of 5.7 μM and a KD of 379 nM. NAMPT is the rate-limiting enzyme in the NAD salvage pathway, which makes it an attractive target for the research of many diseases associated with NAD exhaustion such as neurodegenerative diseases .
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2
2 Cited Publications
Cat. No.: HY-B0244
CAS No.: 55268-74-1
Target:  

Parasite Antibiotic

Research Areas:  

Infection

Praziquantel is a broadly effective trematocide and cestocide, the initial effect of praziquantel on the schistosome may be an interaction of the drug with lipid constituents of the tegumental membrane. Praziquantel is used for the research of schistosomiasis .
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2
2 Cited Publications
Cat. No.: HY-W027968
CAS No.: 531-81-7
Synonyms: 2-Oxochromene-3-carboxylic acid
Target:  

Fluorescent Dye

Research Areas:  

Cancer

Coumarin-3-carboxylic acid (2- Oxochromene-3-carboxylic acid) is an important initial compound for the synthesis of coumarins which are well known natural products for their diverse biological activities. Lanthanide complexes of Coumarin-3-carboxylic acid exhibit antiproliferative activity towards K-562 cell line .
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1
1 Cited Publications
Cat. No.: HY-N2036
CAS No.: 740-33-0
Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with ?anti-EV71 activity. Mosloflavone? inhibits VP2 virus replication and protein expression during the initial stage of virus infection and inhibits viral VP2 capsid protein synthesis. Mosloflavone is a promising biocide and inhibits P. aeruginosa virulence and biofilm formation.
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1
1 Cited Publications
Cat. No.: HY-P1409A
Target:  

Potassium Channel

Research Areas:  

Inflammation/Immunology

ADWX 1 TFA is a new peptide inhibitor that is potent and selective for Kv1.3 with an IC50 value of 1.89 pM. ADWX 1 inhibits Kv1.3 channel activity specifically to inhibit both the initial calcium signaling and NF-κB activation. ADWX 1 TFA ameliorates the disease in rats of experimental autoimmune encephalomyelitis (EAE) models. ADWX 1 TFA can be used to study T cell-mediated autoimmune diseases .
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Cat. No.: HY-152857
CAS No.: 2565656-70-2
Purity:  99.96%
Synonyms: LY3473329
Target:  

LDLR

Research Areas:  

Cardiovascular Disease

Muvalaplin (LY3473329) is an orally active, selective small molecule inhibitor of lipoprotein (a) (Lp (a)) that disrupts the initial non-covalent interaction between apo(a) and apoB100, preventing the disulphide bond and Lp(a) formation. Muvalaplin reduces the levels of Lp (a) in transgenic mice and in cynomolgus monkeys .
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Cat. No.: HY-108294
CAS No.: 3055-99-0
Purity:  ≥98.0%
Synonyms: Nonaoxyethylene monododecyl ether
Research Areas:  

Others

Nonaethylene glycol monododecyl ether (Nonaoxyethylene monododecyl ether) is a nonionic surfactant and polyethylene glycol (PEG) detergent that can be used to form initial coalesced O/W emulsion droplets, as well as for protein separation and purification .
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Cat. No.: HY-112537S1
Purity:  ≥98.0%
D-Glucose 6-Phosphate- 13C6 disodium xhydrate is a 13C-labeled D-Glucose 6-phosphate disodium xhydrate. D-Glucose 6-phosphate disodium xhydrate is a key central node metabolite in sugar metabolism, serving as the initial metabolite of glycolysis and pentose phosphate pathway, and also a substrate for glycogen synthesis. D-Glucose 6-phosphate disodium xhydrate can act as a metabolic stress signal, especially when phosphoglucomutase (PGI) is inhibited, activating the mTOR pathway, promoting protein synthesis, and thereby participating in the remodeling process of the heart. D-Glucose 6-phosphate disodium xhydrate can be used in research related to non-insulin-dependent diabetes and heart failure.
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Cat. No.: HY-W017189
CAS No.: 4593-90-2
3-Phenylbutyric acid is metabolized by initial oxidation of the benzene ring and by initial oxidation of the side chain. 3-Phenylbutyric acid can be used to isolate Rhodococcus rhodochrous PB1 from compost soil .
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Cat. No.: HY-W040264
CAS No.: 911660-54-3
Synonyms: Lanostenol
24,25-Dihydrolanosterol is a naturally occurring tetracyclic Δ 8-triterpene alcohol that can be found in the seeds of Capsicum annuum. 24,25-Dihydrolanosterol is the initial carbocyclic sterol precursor in animals, fungi, and trypanosomatids, and participates in sterol synthesis .
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Cat. No.: HY-P10495A
Target:  

Peptides

Research Areas:  

Cancer

GPR110 peptide agonist P12 acetate is the acetate salt form of GPR110 peptide agonist P12 (HY-P10495). GPR110 peptide agonist P12 acetateis a peptide that acts as a GPR110 agonist. GPR110 peptide agonist P12 acetate can significantly enhance the initial rate of GPR110 stimulated G protein GTPγS binding. GPR110 peptide agonist P12 acetate mimics the action of natural ligands, causing the extracellular domain (ECD) of the GPR110 to dissociate from the seven transmembrane domains (7TM), exposing the β-strand-13/stalk region at the N-terminus of the 7TM domain, which acts as an agonist to activate G protein signaling. GPR110 peptide agonist P12 acetate can be used in the study of developmental disorders and cancers related to GPR110 .
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Cat. No.: HY-15830
CAS No.: 29261-12-9
Purity:  95.47%
Synonyms: 25,26-Dihydroxycholecalciferol
25,26-Dihydroxyvitamin D3 (25,26-Dihydroxycholecalciferol) is a dihydroxylated derivative and metabolite of Vitamin D3 (HY-15398). 25,26-Dihydroxyvitamin D3 moderately increases serum calcium levels when the initial serum calcium level is low. 25,26-Dihydroxyvitamin D3 promotes intestinal calcium absorption in vitamin D-deficient rats fed a low-calcium diet. 25,26-Dihydroxyvitamin D3 is applicable to research related to osteomalacia .
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Cat. No.: HY-W539799
CAS No.: 1073-23-0
Synonyms: 2,6-Dimethylpyridine N-oxide
Research Areas:  

Others

2,6-Lutidine N-oxide (2,6-Dimethylpyridine N-oxide) is a plant growth regulator that can improve the initial growth of plants and increase early yield and total yield. Lutidine is the dimethyl derivative of pyridine .
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Cat. No.: HY-113632
CAS No.: 75593-17-8
Synonyms: 10Z-Debromohymenialdisine
Debromohymenialdisine (10Z-Debromohymenialdisine) is a pyrrole alkaloid. Debromohymenialdisine has moderate inhibitory activity with an IC50 value of 881 nM in the initial Raf/MEK-1/MAPK signaling cascade assay. Debromohymenialdisine can be used for the research of proliferation and differentiation .
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Cat. No.: HY-100686
CAS No.: 152273-12-6
Purity:  99.85%
Target:  

GABA Receptor

Research Areas:  

Neurological Disease

U93631 is a GABAA receptor inhibitor targeting the picrotoxin (HY-101391) site, which exhibits higher inhibitory potency in receptors lacking α subunits. U93631 blocks GABA-induced chloride currents, exerts a mild initial stimulatory effect on activated currents, but its activity decreases in β2T246F mutant receptors. U93631 can serve as a ligand for the convulsant site of GABAA receptors in relevant studies .
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Cat. No.: HY-P11260
CAS No.: 3051556-89-6
Research Areas:  

Metabolic Disease

MD5 is a selective TMPRSS6 mimetic peptide inhibitor with an IC50 for recombinant human TMPRSS6 protein of 22 nM and a Ki of 3.4 nM. MD5 exhibits the significantly reduced inhibitory effect on Matriptase, with an IC50 of 352 nM and a Ki of 99.2 nM. MD5 exhibits good target specificity and only has a weak inhibitory effect on thrombin (Thrombin), with Ki of 120 nM. MD5 demonstrates good initial drugability and can be used for the study of iron overload diseases (such as hereditary hemochromatosis, β-thalassemia) .
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Cat. No.: HY-P990201
Anti-Mouse L-Selectin/CD62L Antibody (Mel-14) is an anti-mouse L-Selectin/CD62L IgG2a monoclonal antibody. Anti-Mouse L-Selectin/CD62L Antibody (Mel-14) can significantly inhibit the migration of T cells and B cells. Anti-Mouse L-Selectin/CD62L Antibody (Mel-14) can block initial lymphocyte homing. Anti-Mouse L-Selectin/CD62L Antibody (Mel-14) can be used for researches on inflammation, metabolic and infection conditions such as diabetes and parasitic infections .
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