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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
inositol analog
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "inositol analog" in MCE Product Catalog:
Cat. No.: HY-W016509
CAS No.: 488-58-4
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Cat. No.: HY-117087
CAS No.: 1071544-43-8
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K103 is an inhibitor discovered from the screen that is an analog of the serotonin antagonist benzazocine. K103 exhibited inhibition of SHIP homologues, labelling it a pan-SHIP1/2 inhibitor, but the molecule had no effect on another 5' inositol phosphatase, OCRL. In line with the "two PIPs hypothesis", the molecule exhibited significant anti-tumour effects against a variety of cell lines, particularly breast cancer cells. Additional studies with K103 revealed that inhibition of SHIP1/2 in multiple myeloma cells resulted in G2/M cell cycle arrest followed by extensive apoptosis via activation of the caspase cascade. K103 fits the commonly used small molecule agent property profile, but while this work was being conducted, it was discovered that K103 caused psychoactive effects in mice, which limited the utility of the molecule in vivo. Therefore, certain synthetic studies were conducted on this tryptamine to identify the features that needed to be present in the molecule to maintain pan-SHIP1/2 inhibition in order to design an inhibitor with favourable pharmacodynamic properties and an improved side effect profile.
Cat. No.: HY-W016509R
CAS No.: 488-58-4
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Cat. No.: HY-161798
Orpinolide is a withanolide analog that has anti-leukemia properties. It disrupts the internal balance of the Golgi apparatus, which is related to signaling through inositol 4-phosphate at the interface of the endoplasmic reticulum and Golgi membrane .
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Cat. No.: HY-108654
CAS No.: 917567-60-3
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PSB 0474 (3-phenacyl-UDP) is a UDP (HY-113359) analog and selective P2Y6 receptor agonist, with an EC50 value of 70 nM for the hP2Y6 receptor. PSB 0474 activates Phospholipase C-coupled receptors to increase intracellular inositol phosphate levels. PSB 0474 enhances NO release by upregulating inducible iNOS and induces Apoptosis. PSB 0474 increases micturition frequency in urine of anesthetized rats, without altering bladder contraction amplitude/duration or causing urothelial damage. PSB 0474 can be used in studies related to chronic brain inflammation .
Cat. No.: HY-172742
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Dioctanoyl PI(3,4)P2 (sodium) is a synthetic analog of natural Ptdlns featuring C8:0 fatty acids at the sn-1 and sn-2 positions. Dioctanoyl PI(3,4)P2 (sodium) contains the same inositol and diacylglycerol (DAG) stereochemistry as the natural Ptdlns .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
