917567-60-3
Chemical Structure
PSB 0474
- CAS No.: 917567-60-3
- Formula:C17H20N2O13P2
- Molecular Weight:522.29
IUPAC Name: ((2R,3S,4R,5R)-5-(2,4-dioxo-3-(2-oxo-2-phenylethyl)-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl trihydrogen diphosphate
InChIKey: SEUHNFHNNANEAJ-DTZQCDIJSA-N
SMILES: O[C@H]([C@@H]1O)[C@@](N(C=CC2=O)C(N2CC(C3=CC=CC=C3)=O)=O)([H])O[C@@H]1CO[P](O[P](O)(O)=O)(O)=O
Biological Activity: PSB 0474 (3-phenacyl-UDP) is a UDP (HY-113359) analog and selective P2Y6 receptor agonist, with an EC50 value of 70 nM for the hP2Y6 receptor. PSB 0474 activates Phospholipase C-coupled receptors to increase intracellular inositol phosphate levels. PSB 0474 enhances NO release by upregulating inducible iNOS and induces Apoptosis. PSB 0474 increases micturition frequency in urine of anesthetized rats, without altering bladder contraction amplitude/duration or causing urothelial damage. PSB 0474 can be used in studies related to chronic brain inflammation[1][2][3].
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PSB 0474 | PSB 0474 (3-phenacyl-UDP) is a UDP (HY-113359) analog and selective P2Y6 receptor agonist, with an EC50 value of 70 nM for the hP2Y6 receptor. PSB 0474 activates Phospholipase C-coupled receptors to increase intracellular inositol phosphate levels. PSB 0474 enhances NO release by upregulating inducible iNOS and induces Apoptosis. PSB 0474 increases micturition frequency in urine of anesthetized rats, without altering bladder contraction amplitude/duration or causing urothelial damage. PSB 0474 can be used in studies related to chronic brain inflammation. | |||||||||||||||||||||
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- [1]. El-Tayeb A, et al. Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors. J Med Chem. 2006;49(24):7076-7087. [Content Brief]
- [2]. Quintas C, et al. Microglia P2Y₆ receptors mediate nitric oxide release and astrocyte apoptosis. J Neuroinflammation. 2014;11:141. Published 2014 Sep 3. [Content Brief]
- [3]. Carneiro I, et al. Activation of P2Y6 receptors increases the voiding frequency in anaesthetized rats by releasing ATP from the bladder urothelium. Br J Pharmacol. 2014;171(14):3404-3419. [Content Brief]
Keywords
