PSB 0474

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PSB 0474 (3-phenacyl-UDP) is a selective and potent P2Y₆ receptor agonist with an EC₅₀ of 70 nM. PSB 0474 inhibits cell proliferation, increases NO release in astrocytes and microglia cells. PSB 0474 induces astrocytes apoptosis.

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PSB 0474 Chemical Structure

CAS No. : 917567-60-3

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Description	PSB 0474 (3-phenacyl-UDP) is a selective and potent P2Y₆ receptor agonist with an EC₅₀ of 70 nM^[1]. PSB 0474 inhibits cell proliferation, increases NO release in astrocytes and microglia cells. PSB 0474 induces astrocytes apoptosis^[2].
IC₅₀ & Target	IC₅₀: 70 nM (P2Y₆)^[1]
Molecular Weight	522.29
Formula	C₁₇H₂₀N₂O₁₃P₂
CAS No.	917567-60-3
SMILES	O[C@H]([C@@H]1O)[C@@](N(C=CC2=O)C(N2CC(C3=CC=CC=C3)=O)=O)([H])O[C@@H]1CO[P](O[P](O)(O)=O)(O)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (269 KB) Handling Instructions (2659 KB)
References	[1]. Ali El-Tayeb, et al. Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors. J Med Chem. 2006 Nov 30;49(24):7076-87. [Content Brief] [2]. Clara Quintas, et al. Microglia P2Y₆ receptors mediate nitric oxide release and astrocyte apoptosis. J Neuroinflammation. 2014 Sep 3;11:141. [Content Brief]

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PSB 0474917567-60-3PSB0474PSB-0474P2Y ReceptorApoptosismicrogliaastrocyteNO releaseInhibitorinhibitorinhibit

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PSB 0474

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