2. GPCR/G Protein
  3. P2Y Receptor Arrestin
  4. MRS2365

MRS2365 is a potent and selective P2Y1 receptor (EC50=0.4 nM) /[35S]GTPγS binding/β-arrestin 2 recruitment agonist with an EC50 of 0.4 nM. MRS2365 relieves mechanical allodynia and increases mechanical sensitivity. MRS2365 shows little agonist or antagonist activity at the P2Y12 or P2Y13 receptors.

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MRS2365 Chemical Structure

MRS2365 Chemical Structure

CAS No. : 436847-09-5

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MRS2365 Related Antibodies

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Description

MRS2365 is a potent and selective P2Y1 receptor (EC50=0.4 nM) /[35S]GTPγS binding/β-arrestin 2 recruitment agonist with an EC50 of 0.4 nM. MRS2365 relieves mechanical allodynia and increases mechanical sensitivity. MRS2365 shows little agonist or antagonist activity at the P2Y12 or P2Y13 receptors[1][2][3][4].

IC50 & Target[1]

P2Y1 Receptor

0.4 nM (EC50)

In Vitro

MRS2365 (1 µM or 3 µM; 2 min) weakens adenosine diphosphate (ADP)-induced platelet aggregation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MRS2365 Related Antibodies
In Vivo

MRS2365 (0.03-0.3 mg/kg; i.p.; single dose) significantly alleviates the mechanical allodynia in the male wistar rats neuropathy (Seltzer) model with dose-dependent manner[3].
MRS2365 (0.1-2 mg/kg; i.p.; single dose) increases the paw withdrawal threshold (PWT) in male wistar rats with neuropathic pain model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats with neuropathic pain(250-350 g)[3].
Dosage: 0.03, 0.1, 0.3, 1 and 2 mg/kg.
Administration: Intraperitoneal injection; single dose.
Result: Relieved mechanical allodynia and increased the paw withdrawal threshold.
Molecular Weight

483.33

Formula

C13H19N5O9P2S
CAS No.
SMILES

O=P(O)(OP(O)(O)=O)OC[C@]12[C@@H](O)[C@@H](O)[C@H](N3C=NC4=C(N)N=C(SC)N=C34)[C@@]1([H])C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MRS2365 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MRS2365436847-09-5MRS 2365MRS-2365P2Y ReceptorArrestinPlateletsADPPWTMale Wistar ratsNeuropathicInhibitorinhibitorinhibit

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