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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
53 Results for "
membrane translocation
" in MedChemExpress (MCE) Product Catalog:
Products (53)
53 Results for "membrane translocation" in MCE Product Catalog:
334
334 Publications Verification
Cat. No.: HY-18749
CAS No.: 305834-79-1
Target:
Research Areas:
SC79, a unique specific and BBB permeable Akt activator, activates Akt in the cytosol and inhibits Akt membrane translocation. SC79 specifically binds to the PH domain of Akt .
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25 Cited Publications
Target:
Research Areas:
GW806742X, an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, binds the MLKL pseudokinase domain with a Kd of 9.3 μM. GW806742X has activity against VEGFR2 (IC50=2 nM). GW806742X retards MLKL membrane translocation and inhibits necroptosis .
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25 Cited Publications
Target:
Research Areas:
GW806742X hydrochloride, an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, binds the MLKL pseudokinase domain with a Kd of 9.3 μM. GW806742X hydrochloride has activity against VEGFR2 (IC50=2 nM). GW806742X hydrochloride retards MLKL membrane translocation and inhibits necroptosis .
5
4
2
2 Cited Publications
Cat. No.: HY-A0183
CAS No.: 1446756-47-3
Synonyms: Phospholipids, phosphatidylserines; Serine glycerophosphatides
Category:
Target:
1
1
Research Areas:
Alkaline Phosphatase (Apase), Calf intestinal is an alkaline phosphatase from Calf intestinal, and is one of the most active alkaline phosphatases. Alkaline Phosphatase, Calf intestinal is an orally active membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline Phosphatase, Calf intestinal reduces myeloperoxidase activity and bacterial translocation. Alkaline Phosphatase, Calf intestinal improves survival rate of mice infected with E. coli. Alkaline Phosphatase, Calf intestinal improves TNBS-induced colon inflammation .
1
1 Cited Publications
API-1 is a potent selective Akt/PKB inhibitor that reduces the level of phosphorylated Akt (IC50 = 0.8 μM). API-1 binds to the PH domain and inhibits Akt membrane translocation. API-1 induces c-FLIP degradation. API-1 reduces cell proliferation and induces apoptosis. API-1 decreases tumor growth in mouse xenograft model .
1
Research Areas:
Alkaline Phosphatase (Apase), microorganism is an alkaline phosphatase from microorganism, and is one of the most active alkaline phosphatases. Alkaline phosphatase, microorganism is an orally active membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase, microorganism reduces myeloperoxidase activity and bacterial translocation. Alkaline phosphatase, microorganism improves survival rate of mice infected with E. coli. Alkaline phosphatase, microorganism improves TNBS-induced colon inflammation .
1
Research Areas:
Alkaline Phosphatase (Apase), Escherichia coli is an alkaline phosphatase from Escherichia coli, and is one of the most active alkaline phosphatases. Alkaline phosphatase, Escherichia coli is an orally active membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase, Escherichia coli reduces myeloperoxidase activity and bacterial translocation. Alkaline phosphatase, Escherichia coli improves survival rate of mice infected with E. coli. Alkaline phosphatase, Escherichia coli improves TNBS-induced colon inflammation .
1
1 Cited Publications
Cat. No.: HY-N0857
CAS No.: 79233-15-1
1
Research Areas:
Alkaline Phosphatase (Apase), Chicken Intestine is an alkaline phosphatase from Chicken Intestine, and is one of the most active alkaline phosphatases. Alkaline phosphatase, Chicken Intestine is an orally active membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase, Chicken Intestine reduces myeloperoxidase activity and bacterial translocation. Alkaline phosphatase, Chicken Intestine improves survival rate of mice infected with E. coli. Alkaline phosphatase, Chicken Intestine improves TNBS-induced colon inflammation .
Cat. No.: HY-D1612
CAS No.: 133867-53-5
Cat. No.: HY-116003
CAS No.: 263399-35-5
Target:
Cat. No.: HY-W1126235
CAS No.: 2253733-45-6
Synonyms: D223
Target:
Research Areas:
DS02312223 (D223) is a molecular glue that promotes the binding of RAS to PI3Kα, with a Kd of 0.76 μM for p110α. DS02312223 increases the binding affinity between GTP-bound KRAS (KRAS-GMPPNP) and p110α by nearly three orders of magnitude (KD = 0.017 μM). DS02312223 stimulates the translocation of GLUT4 to the plasma membrane. DS02312223 promotes glucose uptake in the absence of insulin. DS02312223 can be used in diabetes research .
Synonyms: CID2440433
Target:
Research Areas:
ML-184 (CID244033) is a selective GPR55 agonist with an EC50 of 250 nM, more than 100-fold selectivity for GPR55 over GPR35, CB1, and CB2. ML-184 induces ERK1/2 phosphorylation and PKCβII translocation to the plasma membrane via activation of GPR55. ML-184 (CID2440433) increases the proliferation of neural stem cells and promotes neuronal differentiation in vitro .
Cat. No.: HY-D1735
CAS No.: 571186-05-5
Synonyms: Golgi-Red Tracke
Cat. No.: HY-N0566
CAS No.: 85999-40-2
Synonyms: Anemosapogenin
Cat. No.: HY-P3012
CAS No.: 107200-92-0
Research Areas:
Cathepsin G is a pH-dependent serine protease. Cathepsin G hydrolyzes diverse synthetic and protein substrates and remodels extracellular matrix. Cathepsin G exerts immunomodulatory effects via recruiting phagocytes, enhancing T cell motility, activating ERK1/2 and p38 MAPK signaling, and mediating PKCζ membrane translocation. Cathepsin G regulates inflammatory responses by cleaving inflammatory mediators. Cathepsin G participates in vascular regulation by converting angiotensin I to angiotensin II. Cathepsin G induces PAR4-dependent platelet activation, facilitates platelet-neutrophil aggregation, and mediates VITT-related NETosis, thrombus formation. Cathepsin G can be used for the research of immune thrombotic thrombocytopenia, cardiovascular disease, and select autoimmune and inflammatory diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
