2253733-45-6
Chemical Structure
DS02312223
Synonym(s): D223
- CAS No.: 2253733-45-6
- Formula:C29H32FN5O5S
- Molecular Weight:581.66
IUPAC Name: tert-butyl (2-(2-(2-(4-((4-(2-amino-2-oxoethyl)-2-fluorophenyl)amino)thieno[2,3-d]pyridazin-7-yl)phenoxy)ethoxy)ethyl)carbamate
InChIKey: NFCHONNVHGPRMI-UHFFFAOYSA-N
SMILES: CC(C)(OC(NCCOCCOC1=C(C=CC=C1)C2=C3SC=CC3=C(N=N2)NC4=C(C=C(C=C4)CC(N)=O)F)=O)C
Biological Activity: DS02312223 (D223) is a molecular glue that promotes the binding of RAS to PI3Kα, with a Kd of 0.76 μM for p110α. DS02312223 increases the binding affinity between GTP-bound KRAS (KRAS-GMPPNP) and p110α by nearly three orders of magnitude (KD = 0.017 μM). DS02312223 stimulates the translocation of GLUT4 to the plasma membrane. DS02312223 promotes glucose uptake in the absence of insulin. DS02312223 can be used in diabetes research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DS02312223 | 98.24% | DS02312223 (D223) is a molecular glue that promotes the binding of RAS to PI3Kα, with a Kd of 0.76 μM for p110α. DS02312223 increases the binding affinity between GTP-bound KRAS (KRAS-GMPPNP) and p110α by nearly three orders of magnitude (KD = 0.017 μM). DS02312223 stimulates the translocation of GLUT4 to the plasma membrane. DS02312223 promotes glucose uptake in the absence of insulin. DS02312223 can be used in diabetes research. | ||||||||||||||||||||
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Keywords
