2. Search Result
Search Result
Results for "

monovalent

" in MedChemExpress (MCE) Product Catalog:

38

Inhibitors & Agonists

2

Fluorescent Dye

11

Biochemical Assay Reagents

4

Peptides

4

Inhibitory Antibodies

4

Natural
Products

8

Click Chemistry

4

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-17409
    Nystatin
    50+ Cited Publications

    		 Fungal Antibiotic Apoptosis Bacterial Infection Cancer
    Nystatin is an orally active polyene antifungal antibiotic effective against yeast and mycoplasma. Nystatin increases the permeability of plasma membranes to small monovalent ions, including chloridion . Nystatin is a cholesterol-sequestering agent , partially prevents Oxaliplatin-induced lipid raft aggregation, DR4 and DR5 clustering, and thereby reduces apoptosis .
    Nystatin
  • HY-P99250
    Onartuzumab
    2 Publications Verification

    MetMAb

    		 c-Met/HGFR Cancer
    Onartuzumab (MetMAb) is a unique, humanized and affinity-matured monovalent (one-armed) monoclonal antibody against the MET receptor. Onartuzumab potently inhibits HGF binding and receptor phosphorylation and signaling. Onartuzumab has antibody-like pharmacokinetics and antitumor activity .
    Onartuzumab
  • HY-N6790
    Nonactin

    Ammonium ionophore I

    		 Oxidative Phosphorylation Potassium Channel Mitochondrial Metabolism Bacterial Influenza Virus Apoptosis Antibiotic HSP Infection Cancer
    Nonactin is a macrotetrolide antibiotic and mitochondrial uncoupler with antibacterial, insecticidal, and acaricidal activities. Nonactin acts as an ionophore for monovalent cations, including K +, and NH4 +, and it can also inhibit the surface expression of endogenous HSP60. In addition, Nonactin can induce apoptosis in β-catenin mutant tumor cells and has anti-tumor activity .
    Nonactin
  • HY-108017
    Ferric maltol

    		Biochemical Assay Reagents Metabolic Disease Cancer
    Ferric maltol is an orally active monovalent iron (Fe 3+) complex. Ferric maltol is used in the study of iron deficiency anemia in inflammatory bowel disease .
    Ferric maltol
  • HY-N4302
    Monensin
    35+ Cited Publications

    Monensin A

    		 Exosomes Bacterial Apoptosis Antibiotic Parasite Na+/H+ Exchanger (NHE) Fungal Wnt Infection Cancer
    Monensin (Monensin A), an orally active antibiotic, is an ionophore that mediates Na +/H + exchange. Monensin is a potent Wnt signaling inhibitor. Monensin causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects .
    Monensin
  • HY-A0068
    Aurothioglucose
    2 Publications Verification

    Gold thioglucose

    		 NF-κB HIV Reactive Oxygen Species (ROS) Infection Inflammation/Immunology Cancer
    Aurothioglucose (Gold thioglucose), containing monovalent gold ion, is a potent active-site inhibitor of TrxR1 (thioredoxin reductase 1), with an IC50 of 65 nM. Aurothioglucose inhibits the DNA binding of NF-κB in vitro. Aurothioglucose shows anti-HIV and anti-rheumatic activities .
    Aurothioglucose
  • HY-P2324
    Gramicidin A
    1 Publications Verification

    		 Bacterial HIF/HIF Prolyl-Hydroxylase Antibiotic Infection Cancer
    Gramicidin A is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A induces degradation of hypoxia inducible factor 1 α (HIF-1α) .
    Gramicidin A
  • HY-163638
    BRD4 degrader-1

    		Epigenetic Reader Domain Molecular Glues E1/E2/E3 Enzyme Cancer
    BRD4 degrader-1 (Compound mL 1-50) is a relatively selective, monovalent and covalent BRD4 Molecular glue degrader. BRD4 degrader-1 induces degradation of both long and short isoforms of BRD4 by targeting DCAF16 (an E3 ligase). BRD4 degrader-1 can be used in breast cancer research .
    BRD4 degrader-1
  • HY-P990060
    Denecimig

    Mim8

    		 Factor Xa Cardiovascular Disease
    Denecimig (Mim8) is a factor VIII-mimetic bispecific antibody with micromolar human binding affinity for Factor X and Factor IXa. Denecimig binds Factor X and Factor IXa, localizes both to the phospholipid surface, enhances the Factor IXa-mediated activation of Factor X to Factor Xa, and stimulates the proteolytic activity of Factor IXa via its monovalent anti-Factor IXa arm. Denecimig is applicable to research related to hemophilia A .
    Denecimig
  • HY-173351
    G-6599

    		Epigenetic Reader Domain Cancer
    G-6599 is a monovalent molecular glue-like degrader of SMARCA2/SMARCA4. G-6599 covalently binds to a specific cysteine residue of the E3 ligase FBXO22 in a biotransformation-independent manner, promotes the formation of a ternary complex with SMARCA2/A4, and achieves efficient and specific degradation of the two proteins via the ubiquitin-proteasome pathway. G-6599 is applicable to the research of androgen-dependent prostate cancer and mutant non-small cell lung cancer .
    G-6599
  • HY-P99903
    Simridarlimab

    IBI-322

    		 PD-1/PD-L1 CD47 Inflammation/Immunology Cancer
    Simridarlimab (IBI-322) is a bispecific antibody targeting PD-L1 and CD47. Simridarlimab attenuates CD47 activity in monovalent binding and blockes PD-L1 activity in bivalent binding. Simridarlimab selectively binds to CD47+PD-L1+ tumor cells, effectively inhibits CD47-SIRPα signal and triggered strong tumor cell phagocytosis in vitro .
    Simridarlimab
  • HY-139813
    Phenanthriplatin

    		DNA Alkylator/Crosslinker Cancer
    Phenanthriplatin is a monovalent platinum(II)-based complex with a large cytotoxicity against cancer cells .
    Phenanthriplatin
  • HY-163641
    AR Degrader-1

    		Molecular Glues Androgen Receptor E1/E2/E3 Enzyme Cancer
    AR Degrader-1 (Compound ML 2-9) is a molecular glue androgen receptor (AR) monovalent degrader. AR Degrader-1 degrades AR through DCAF16 (E3 ligase) without obvious cytotoxicity in LNCaP prostate cancer cells .
    AR Degrader-1
  • HY-172273A
    DSPE-PEG2000-Mal-Cys-YEQDPWGVKWWY

    		Liposome Cancer
    DSPE-PEG2000-Mal-Cys-YEQDPWGVKWWY is a PEG compound which composed of DSPE and a M2-polarized macrophages targeting peptide (M2pep, YEQDPWGVKWWY). M2pep is conjugated to a proapoptotic peptide as monovalent or multivalent ligands to concentrate the toxic effect of the peptide to M2 macrophages. DSPE-PEG2000-Mal-Cys-YEQDPWGVKWWY can be used for drug delivery .
    DSPE-PEG2000-Mal-Cys-YEQDPWGVKWWY
  • HY-172273
    DSPE-PEG1000-Mal-Cys-YEQDPWGVKWWY

    		Liposome Cancer
    DSPE-PEG1000-Mal-Cys-YEQDPWGVKWWY is a PEG compound which composed of DSPE and a M2-polarized macrophages targeting peptide (M2pep, YEQDPWGVKWWY). M2pep is conjugated to a proapoptotic peptide as monovalent or multivalent ligands to concentrate the toxic effect of the peptide to M2 macrophages. DSPE-PEG1000-Mal-Cys-YEQDPWGVKWWY can be used for drug delivery .
    DSPE-PEG1000-Mal-Cys-YEQDPWGVKWWY
  • HY-111525
    Monactin

    		Oxidative Phosphorylation Bacterial Antibiotic Infection
    Monactin is a mactrotetralide antibiotic and a non-selective ionophore for monovalent cations, including potassium, sodium, and lithium. Monactin is isolated from Streptomyces and has antiproliferative activity .
    Monactin
  • HY-W1049105
    mPEG2000-Alkyne

    		Biochemical Assay Reagents Others
    mPEG2000-Alkyne is a PEG derivative. The alkynyl group can react with azide in aqueous solution under the catalysis of monovalent copper. Polyethylene glycol derivatives can increase the solubility and stability of drugs, reduce the immunogenicity of peptides, and have good biocompatibility .
    mPEG2000-Alkyne
  • HY-155294
    SM-122

    		IAP Apoptosis Cancer
    SM-122 is a monovalent Smac mimetic targeting cellular inhibitor of apoptosis protein (cIAP)-1/2. SM-122 can induce cIAP-1/2 degradation and weakly induce apoptosis in tumor cells. SM-122 can be used for the research of cancer, such as breast cancer .
    SM-122
  • HY-163639
    BRD4 degrader-2

    		Molecular Glues Epigenetic Reader Domain E1/E2/E3 Enzyme Cancer
    BRD4 degrader-2 (Compound JP-2-197) is a covalent monovalent molecular glue BRD4degrader that induces a ternary complex formation between BRD4 and RNF126. BRD4 degrader-2 targets RNF126 (E3 ligase) and degrades both the long and short isoforms of BRD4 in cells .
    BRD4 degrader-2
  • HY-172273C
    DSPE-PEG3400-M2pep

    		Liposome Cancer
    DSPE-PEG3400-Mal-Cys-YEQDPWGVKWWY is a PEG compound which composed of DSPE and a M2-polarized macrophages targeting peptide (M2pep, YEQDPWGVKWWY). M2pep is conjugated to a proapoptotic peptide as monovalent or multivalent ligands to concentrate the toxic effect of the peptide to M2 macrophages. DSPE-PEG3400-Mal-Cys-YEQDPWGVKWWY can be used for drug delivery .
    DSPE-PEG3400-M2pep
  • HY-P3711
    SPAI-1

    		Na+/K+ ATPase Others
    SPAI-1 is a specific inhibitor for monovalent cation transporting ATPases. SPAI-1 is a peptide isolated from porcine duodenum, inhibits Na +, K +-ATPase and H +, K +-ATPase in vitro, stimulates Mg 2+-ATPase .
    SPAI-1
  • HY-129525A
    Sulfo-SIAB sodium

    		ADC Linker Cancer
    Sulfo-SIAB sodium is a nonclaevable monovalent bilinker.
    Sulfo-SIAB sodium
  • HY-W1049091C
    mPEG20000-Alkyne

    		Biochemical Assay Reagents Others
    mPEG20000-Alkyne is a PEG derivative. The alkynyl group can react with azide in aqueous solution under the catalysis of monovalent copper. Polyethylene glycol derivatives can increase the solubility and stability of drugs, reduce the immunogenicity of peptides, and have good biocompatibility .
    mPEG20000-Alkyne
  • HY-P2324A
    Gramicidin A TFA

    		Antibiotic Bacterial Infection
    Gramicidin A (TFA) is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A (TFA) is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A (TFA) induces degradation of hypoxia inducible factor 1 α (HIF-1α) .
    Gramicidin A TFA
  • HY-P10228
    S-Thanatin

    		Fungal Bacterial Infection
    S-Thanatin is an insect antimicrobial peptide with potent broad-spectrum antibacterial activity. S-Thanatin can inhibit the activity of Gram-negative bacteria, Gram-positive bacteria, and fungi, without cytotoxicity. The antibacterial activity of S-Thanatin is not affected by PH value, but monovalent cations (Na +/K +) can reduce its antibacterial activity against Gram-negative bacteria in a dose-dependent manner .
    S-Thanatin
  • HY-172273B
    DSPE-PEG5000-M2pep

    		Liposome Cancer
    DSPE-PEG5000-Mal-Cys-YEQDPWGVKWWY is a PEG compound which composed of DSPE and a M2-polarized macrophages targeting peptide (M2pep, YEQDPWGVKWWY). M2pep is conjugated to a proapoptotic peptide as monovalent or multivalent ligands to concentrate the toxic effect of the peptide to M2 macrophages. DSPE-PEG5000-Mal-Cys-YEQDPWGVKWWY can be used for drug delivery .
    DSPE-PEG5000-M2pep
  • HY-P990716
    Sabestomig

    AZD7789

    		 PD-1/PD-L1 Tim3 Inflammation/Immunology
    Sabestomig (AZD7789) is a monovalent bispecific antibody targeting PD-1 and TIM-3. Sabestomig binds to PD-1 and an epitope in the TIM-3 IgV domain outside the phosphatidylserine-binding cleft, thereby precisely regulating immune responses. Sabestomig promotes IL-2 production, efferocytosis and cross-presentation of tumor antigens, and enhances the release of anti-tumor T cell cytokines, cytotoxicity, and secretion of IFN-γ. Sabestomig inhibits the growth of solid tumors, prolongs the duration of tumor suppression, and significantly enhances anti-tumor responses following anti-PD-1 therapy. Sabestomig has been used in studies related to non-small cell lung cancer and classical Hodgkin lymphoma .
    Sabestomig
  • HY-D3255
    CTAP-1

    		Fluorescent Dye Others
    CTAP-1 is a monovalent copper ion probe. CTAP-1 binds to monovalent copper Cu (I) to inhibit photoinduced electron transfer, thereby enhancing fluorescence emission. CTAP-1 produces copper-dependent perinuclear staining that colocalizes with mitochondria and the Golgi apparatus. CTAP-1 can be used for imaging Cu (I) pools, excitation/emission Wavelength: 365/480 nm .
    CTAP-1
  • HY-E70953
    Pyruvate Kinase/Lactic Dehydrogenase enzymes, Rabbit

    		Pyruvate Kinase Lactate Dehydrogenase Metabolic Disease
    Pyruvate Kinase/Lactic Dehydrogenase enzymes, Rabbit catalyzes an ATP-dependent phosphorylation of glycolate to yield 2-phosphoglycolate. Pyruvate kinase requires bivalent and monovalent cations such as Mg 2+ and K + respectively for activation to occur.
    Pyruvate Kinase/Lactic Dehydrogenase enzymes, Rabbit
  • HY-D3212
    Crisp-17

    		Fluorescent Dye Metabolic Disease
    Crisp-17 is a monovalent copper ion probe. Crisp-17 can be used to characterize cellular phenotypes associated with copper metabolism defects. Crisp-17 is applicable to research related to Menkes disease .
    Crisp-17
  • HY-W075796
    Copper(I) thiocyanate

    		Environmental Pollutants Drug Intermediate Others
    Copper (I) thiocyanate is a monovalent copper pseudohalide that exists in two crystalline forms, α and β, both containing bridging thiocyanate groups. Copper (I) thiocyanate can form coordination complexes with ligands such as triphenylphosphine and pyridine .
    Copper(I) thiocyanate
  • HY-W1049091B
    mPEG10000-Alkyne

    		Biochemical Assay Reagents Others
    mPEG10000-Alkyne is a PEG derivative. The alkynyl group can react with azide in aqueous solution under the catalysis of monovalent copper. Polyethylene glycol derivatives can increase the solubility and stability of drugs, reduce the immunogenicity of peptides, and have good biocompatibility .
    mPEG10000-Alkyne
  • HY-W1049091D
    mPEG40000-Alkyne

    		Biochemical Assay Reagents Others
    mPEG40000-Alkyne is a PEG derivative. The alkynyl group can react with azide in aqueous solution under the catalysis of monovalent copper. Polyethylene glycol derivatives can increase the solubility and stability of drugs, reduce the immunogenicity of peptides, and have good biocompatibility .
    mPEG40000-Alkyne
  • HY-W1049091A
    mPEG5000-Alkyne

    		Biochemical Assay Reagents Others
    mPEG5000-Alkyne is a PEG derivative. The alkynyl group can react with azide in aqueous solution under the catalysis of monovalent copper. Polyethylene glycol derivatives can increase the solubility and stability of drugs, reduce the immunogenicity of peptides, and have good biocompatibility .
    mPEG5000-Alkyne
  • HY-W1049091
    mPEG1000-Alkyne

    		Biochemical Assay Reagents Others
    mPEG1000-Alkyne is a PEG derivative. The alkynyl group can react with azide in aqueous solution under the catalysis of monovalent copper. Polyethylene glycol derivatives can increase the solubility and stability of drugs, reduce the immunogenicity of peptides, and have good biocompatibility .
    mPEG1000-Alkyne
  • HY-W1049091E
    mPEG3400-Alkyne

    		Biochemical Assay Reagents Others
    mPEG3400-Alkyne is a PEG derivative. The alkynyl group can react with azide in aqueous solution under the catalysis of monovalent copper. Polyethylene glycol derivatives can increase the solubility and stability of drugs, reduce the immunogenicity of peptides, and have good biocompatibility .
    mPEG3400-Alkyne
  • HY-E71164
    1,5-Anhydro-D-fructose dehydratase

    		Biochemical Assay Reagents Others
    1,5-Anhydro-D-fructose dehydratase (EC 4.2.1.111) catalyses one of the steps in the anhydrofructose pathway, which leads to the degradation of glycogen and starch via 1,5-Anhydro-D-fructose . Requires divalent (Ca2+ or Mg2+) or monovalent cations (Na+) for optimal activity.
    1,5-Anhydro-D-fructose dehydratase
  • HY-183268
    TRPM4-IN-4

    		TRP Channel Cancer
    TRPM4-IN-4 (Compound 118) is a selective TRPM4 inhibitor with an IC50 value of 0.339 μM against hTRPM4. TRPM4-IN-4 inhibits hTRPM4 and mTRPM4. TRPM4-IN-4 can be used for the research of colorectal cancer .
    TRPM4-IN-4

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: