country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-155294

Copy Link Print Information

SM-122

SM-122 is a monovalent Smac mimetic targeting cellular inhibitor of apoptosis protein (cIAP)-1/2. SM-122 can induce cIAP-1/2 degradation and weakly induce apoptosis in tumor cells. SM-122 can be used for the research of cancer, such as breast cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 874270-38-9
Formel: C₂₈H₃₆N₄O₃
Molecular Weight:476.61

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

SM-122 Chemical Structure

CAS. Nr.: 874270-38-9

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

cIAP-1

cIAP-2

Alle IAP Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	1400 nM Compound: 18; SM-122	Cytotoxicity against human HL60 cells assessed as reduction in cell viability Cytotoxicity against human HL60 cells assessed as reduction in cell viability	[PMID: 30676015]
MDA-MB-231	EC₅₀	1.03 μM Compound: 1, SM-122	Reversal of human XIAP BIR3-mediated suppression of cytochrome c-induced caspase-3/-7 activity in human MDA-MB-231 cell lysate after 30 mins by cell free functional assay Reversal of human XIAP BIR3-mediated suppression of cytochrome c-induced caspase-3/-7 activity in human MDA-MB-231 cell lysate after 30 mins by cell free functional assay	[PMID: 19049347]
MDA-MB-231	IC₅₀	259 nM Compound: 1, SM-122	Growth inhibition of human MDA-MB-231 cells after 4 days by WST8 assay Growth inhibition of human MDA-MB-231 cells after 4 days by WST8 assay	[PMID: 19049347]
MDA-MB-231	IC₅₀	259 nM Compound: 7, SM-122	Growth inhibition of human MDA-MB-231 cells after 4 days by WST-8 assay Growth inhibition of human MDA-MB-231 cells after 4 days by WST-8 assay	[PMID: 19138149]
MDA-MB-231	IC₅₀	410 nM Compound: 20	Growth inhibition of human MDA-MB-231 cells after 4 days by WST-8 assay Growth inhibition of human MDA-MB-231 cells after 4 days by WST-8 assay	[PMID: 18954041]
MDA-MB-231	IC₅₀	633 nM Compound: 15, SM-125	Growth inhibition of human MDA-MB-231 cells after 2 to 3 hrs by WST8 assay Growth inhibition of human MDA-MB-231 cells after 2 to 3 hrs by WST8 assay	[PMID: 21462933]
SK-OV-3	IC₅₀	900 nM Compound: 20	Growth inhibition of human SKOV3 cells after 4 days by WST8 assay Growth inhibition of human SKOV3 cells after 4 days by WST8 assay	[PMID: 18954041]

Chemical Information

CAS. Nr. 874270-38-9
Molecular Weight 476.61
Formel C₂₈H₃₆N₄O₃
SMILES

O=C([C@H]1N2[C@](CCCC[C@@H](C2=O)NC([C@H](C)NC)=O)([H])CC1)NC(C3=CC=CC=C3)C4=CC=CC=C4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Lu J, et al. SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP. Cancer Res. 2008 Nov 15;68(22):9384-93. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

SM-122

Alle IAP Isoform-spezifische Produkte anzeigen