SM-122
SM-122 is a monovalent Smac mimetic targeting cellular inhibitor of apoptosis protein (cIAP)-1/2. SM-122 can induce cIAP-1/2 degradation and weakly induce apoptosis in tumor cells. SM-122 can be used for the research of cancer, such as breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 874270-38-9
- Formula: C28H36N4O3
- Molecular Weight:476.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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cIAP-1 |
cIAP-2 |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | IC50 |
1400 nM
Compound: 18; SM-122
|
Cytotoxicity against human HL60 cells assessed as reduction in cell viability
Cytotoxicity against human HL60 cells assessed as reduction in cell viability
|
[PMID: 30676015] |
| MDA-MB-231 | EC50 |
1.03 μM
Compound: 1, SM-122
|
Reversal of human XIAP BIR3-mediated suppression of cytochrome c-induced caspase-3/-7 activity in human MDA-MB-231 cell lysate after 30 mins by cell free functional assay
Reversal of human XIAP BIR3-mediated suppression of cytochrome c-induced caspase-3/-7 activity in human MDA-MB-231 cell lysate after 30 mins by cell free functional assay
|
[PMID: 19049347] |
| MDA-MB-231 | IC50 |
259 nM
Compound: 1, SM-122
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Growth inhibition of human MDA-MB-231 cells after 4 days by WST8 assay
Growth inhibition of human MDA-MB-231 cells after 4 days by WST8 assay
|
[PMID: 19049347] |
| MDA-MB-231 | IC50 |
259 nM
Compound: 7, SM-122
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Growth inhibition of human MDA-MB-231 cells after 4 days by WST-8 assay
Growth inhibition of human MDA-MB-231 cells after 4 days by WST-8 assay
|
[PMID: 19138149] |
| MDA-MB-231 | IC50 |
410 nM
Compound: 20
|
Growth inhibition of human MDA-MB-231 cells after 4 days by WST-8 assay
Growth inhibition of human MDA-MB-231 cells after 4 days by WST-8 assay
|
[PMID: 18954041] |
| MDA-MB-231 | IC50 |
633 nM
Compound: 15, SM-125
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Growth inhibition of human MDA-MB-231 cells after 2 to 3 hrs by WST8 assay
Growth inhibition of human MDA-MB-231 cells after 2 to 3 hrs by WST8 assay
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[PMID: 21462933] |
| SK-OV-3 | IC50 |
900 nM
Compound: 20
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Growth inhibition of human SKOV3 cells after 4 days by WST8 assay
Growth inhibition of human SKOV3 cells after 4 days by WST8 assay
|
[PMID: 18954041] |
Chemical Information
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CAS No. 874270-38-9
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Molecular Weight 476.61
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Formula C28H36N4O3
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SMILES
O=C([C@H]1N2[C@](CCCC[C@@H](C2=O)NC([C@H](C)NC)=O)([H])CC1)NC(C3=CC=CC=C3)C4=CC=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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