103 Results for "

mushrooms

" in MedChemExpress (MCE) Product Catalog:
Products (103)

103 Results for "mushrooms" in MCE Product Catalog:

48
α-Amanitin
α-Amanitin
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48 Publications Verification
Cat. No.: HY-19610
CAS No.: 23109-05-9
Synonyms: α-Amatoxin
Target:  

DNA/RNA Synthesis ADC Payloads

연구분야:  

Cancer

α-Amanitin is the principal toxin of several deadly poisonous mushrooms, exerting its toxic function by inhibiting RNA-polymerase II.
23
Phalloidin
Phalloidin
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23 Cited Publications
Cat. No.: HY-P0028
CAS No.: 17466-45-4
Target:  

Fluorescent Dye

연구분야:  

Others

Phalloidin is a mushroom-derived toxin which can be used to label F-actin of the cytoskeleton with fluorochrome .
4
Mulberroside A
Mulberroside A
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4 Cited Publications
Cat. No.: HY-N0619
CAS No.: 102841-42-9
Category:  

Stilbenes Morus alba L. Phenols Polyphenols Plants Moraceae Disease Research Fields Inflammation/Immunology

Target:  

TNF Receptor Interleukin Related Tyrosinase

Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC50 of 53.6 μM .
3
Oxyresveratrol
Oxyresveratrol
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3 Cited Publications
Cat. No.: HY-N1430
CAS No.: 29700-22-9
Synonyms: trans-Oxyresveratrol
Category:  

other families Stilbenes Anti-aging Other Diseases Phenols Polyphenols Plants Disease Research Fields

Target:  

Tyrosinase HSV Autophagy

Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC50 of 28.9 µM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive tyrosinase inhibitor with an IC50 value of 1.2 µM for mushroom tyrosinase. Oxyresveratrol is effective against HSV-1, HSV-2 and varicella-zoster virus, and has neuroprotective effects .
2
Kojic acid
Kojic acid
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2 Cited Publications
Cat. No.: HY-W050154
CAS No.: 501-30-4
Category:  

Infection Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields

Target:  

Parasite Tyrosinase NF-κB CDK

Kojic acid is a substance produced by Aspergillus oryzae that is orally effective and can also be absorbed transdermally. Kojic acid exhibits various biological activities, including anti-aging, anti-nematode, antimicrobial, antioxidant, and anti-inflammatory effects. Kojic acid is a Tyrosinase inhibitor with an Mushroom Tyrosinase IC50 of 182.7 μM. Kojic acid prevents melanin production by capturing copper ions that bind to the tyrosinase active site, thus inhibiting its activation. Kojic acid also suppresses the NF-κB and p21 signaling pathways in human keratinocytes. Kojic acid derivatives have anticancer activity .
2
Vialinin A
Vialinin A
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2 Cited Publications
Cat. No.: HY-103435
CAS No.: 858134-23-3
Purity:  99.90%
Synonyms: Terrestrin A
Target:  

Deubiquitinase TNF Receptor E1/E2/E3 Enzyme Keap1-Nrf2

연구분야:  

Inflammation/Immunology Cancer

Vialinin A (Terrestrin A) is a p-terphenyl compound that can be derived from a Chinese edible mushroom. Vialinin A is an inhibitor of ubiquitin-specific peptidase 4 (USP4) and has anti-inflammatory and antioxidant properties. Vialinin A can alleviate cerebral ischaemia-reperfusion injury-induced neurological deficits and neuronal apoptosis. Vialinin A promotes activation of Keap1-Nrf2-ARE signaling pathway and increases the protein degradation of Keap1. Vialinin A possesses various pharmacological activities in cancer, Kawasaki disease, asthma, and pathological scarring. Vialinin A is a potent inhibitor of TNF-α, USP4, USP5, and sentrin/SUMO-specific protease 1 (SENP1). Vialinin A can be studied in reseach for autoimmune diseases, cancer and ischaemic stroke .
1
Eritadenine
Eritadenine
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1 Cited Publications
Cat. No.: HY-114866
CAS No.: 23918-98-1
Purity:  97.9%
Synonyms: Lentinacin; D-Eritadenine; Lentysine
Target:  

Parasite Nucleoside Antimetabolite/Analog

연구분야:  

Infection

Eritadenine (D-Eritadenine) is a potent AdoHcyase inhibitor, with an IC50 value of 7 nM. Eritadenine is also an acyclic sugar adenosine analogue. Eritadenine exhibits an inhibitory effect on the growth of Cryptosporidium parvum, with a MIC50 of 3 μM. Eritadenine can be used in the research of colorectal adenocarcinoma .
1
Chlorotoluron
Chlorotoluron
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1 Cited Publications
Cat. No.: HY-B2023
CAS No.: 15545-48-9
Synonyms: Chlortoluron
Target:  

Environmental Pollutants Herbicide

연구분야:  

Others

Chlorotoluron (Chlortoluron) is a urea herbicide. Chlorotoluron serves as a degradation substrate that undergoes dissipation in soil and produces demethylated chlorotoluron metabolites via N-dealkylation. Chlorotoluron is used for pre-emergence and post-emergence weed control in cereals and various other crops .
1
Grifolin
Grifolin
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1 Cited Publications
Cat. No.: HY-N9271
CAS No.: 6903-07-7
Category:  

Microorganisms Phenols Polyphenols

Target:  

Apoptosis

Grifolin is an antineoplastic agent can be isolated from the mushroom Albatrellus confluens and significantly induces apoptosis .
1
4-Chlorocinnamic acid
4-Chlorocinnamic acid
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1 Cited Publications
Cat. No.: HY-Y0729
CAS No.: 1615-02-7
Target:  

Tyrosinase Bacterial Fungal Drug Derivative

연구분야:  

Infection Neurological Disease

4-Chlorocinnamic acid is a derivative of Cinnamic acid (HY-N0610A). 4-Chlorocinnamic acid inhibits the monophenolase and diphenolase activities of mushroom tyrosinase with IC50 values of 0.477 mM and 0.229 mM, respectively. 4-Chlorocinnamic acid inhibits the mycelial growth of Colletotrichum gloeosporioides. 4-Chlorocinnamic acid exhibits anticonvulsant activity against acute epilepsy induced by pentylenetetrazol .
4-Isopropylbenzoic acid
4-Isopropylbenzoic acid
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Cat. No.: HY-W013571
CAS No.: 536-66-3
Synonyms: Cuminic acid; p-Isopropyl benzoic acid
Category:  

Infection other families Bridelia retusa Ketones, Aldehydes, Acids Euphorbiaceae Plants Disease Research Fields

Target:  

Fungal

4-Isopropylbenzoic acid (Cuminic acid; p-Isopropyl benzoic acid) an aromatic monoterpenoid, is isolated from the stem bark of Bridelia retusa. 4-Isopropylbenzoic acid exhibits antifungal activities. 4-Isopropylbenzoic acid is also a reversible and uncompetitive inhibitor of mushroom tyrosinase .
β-Amanitin
β-Amanitin
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Cat. No.: HY-125586
CAS No.: 21150-22-1
Purity:  ≥96.0%
Target:  

DNA/RNA Synthesis ADC Payloads

연구분야:  

Cancer

β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs) .
γ-Amanitin
γ-Amanitin
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Cat. No.: HY-131081
CAS No.: 21150-23-2
Purity:  ≥90.0%
Category:  

Alkaloids Microorganisms Other Alkaloids Disease Research Fields Cancer

Target:  

DNA/RNA Synthesis ADC Payloads

γ-Amanitin an ADC cytotoxin and isolated from the mushroom. γ-Amanitin inhibits RNA polymerase II and disrupts synthesis of mRNA. γ-Amanitin shows similar effects to α-Amanitin and β-Amanitin. γ-Amanitin competitively binds to monoclonal antibody (mAb), with an IC50 of 163.1 ng/mL. γ-Amanitin is toxic to a variety of cells .
Isobutylamido thiazolyl resorcinol
Isobutylamido thiazolyl resorcinol
0 Images
Cat. No.: HY-W251181
CAS No.: 1428450-95-6
Target:  

Tyrosinase

연구분야:  

Metabolic Disease

Isobutylamido thiazolyl resorcinol is a selective hTyr inhibitor with an IC50 of 1.1  μM. Isobutylamido thiazolyl resorcinol shows an IC50 of 108  μM against mushroom Tyrosinase. Isobutylamido thiazolyl resorcinol effectively prevents pigmentation caused by UVB irradiation. Isobutylamido thiazolyl resorcinol significantly improves the visibility of acne-induced hyperpigmentation .
Clitocine
Clitocine
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Cat. No.: HY-118341
CAS No.: 105798-74-1
Purity:  ≥95.0%
Category:  

Alkaloids Microorganisms Other Alkaloids Disease Research Fields Cancer

Target:  

Apoptosis Bcl-2 Family

Clitocine, an adenosine nucleoside analog isolated from mushroom, is a potent and efficacious readthrough agent. Clitocine acts as a suppressor of nonsense mutations and can induce the production of p53 protein in cells harboring p53 nonsense-mutated alleles. Clitocine can induce apoptosis in multidrug-resistant human cancer cells by targeting Mcl-1. Anticancer activity .
Broussoflavonol F
Broussoflavonol F
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Cat. No.: HY-N9330
CAS No.: 162558-94-3
Category:  

Flavonols other families Flavonoids Other Diseases Phenols Polyphenols Plants Disease Research Fields

Target:  

Xanthine Oxidase Ras EGFR MEK PERK Apoptosis

Broussoflavonol F is a potent dual inhibitor of the HER2-RAS-MEK-ERK signaling pathway and mushroom tyrosinase with an IC50 value of 82.3 μM. Broussoflavonol F downregulates the expression of RAS, HER2, phosphorylated BRAF, phosphorylated MEK and phosphorylated Erk proteins. Broussoflavonol F induces cell cycle arrest and apoptosis, and exhibits cytotoxicity in colon cancer cells. Broussoflavonol F inhibits endothelial proliferation, migration and tube formation, suppresses subintestinal vascular development, and reduces the mRNA levels of angiogenesis-associated genes.Broussoflavonol F can be used for colon cancer research .
Tropolone
Tropolone
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Cat. No.: HY-N7135
CAS No.: 533-75-5
Category:  

Olax imbricata Ketones, Aldehydes, Acids Olacaceae Other Diseases Plants Disease Research Fields

Target:  

Tyrosinase Fungal

Tropolone is a seven-membered non-benzenoid aromatic compound, which is the precursor of many Azulene derivatives. Tropolone is a potent mushroom tyrosinase inhibitor with an IC50 value of 0.4 μM. Its inhibitory effect can be achieved by dialysis or excess CU2+ Reversa. Tropolone exhibits broad anti-viral and anti-fungal activity and is synergistic upon co-treatment with nucleos(t)ide analog drugs. Tropolone is a promising candidate for research in osteosarcoma .
3-(2,4-Dihydroxyphenyl)propanoic acid
3-(2,4-Dihydroxyphenyl)propanoic acid
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Cat. No.: HY-N1750
CAS No.: 5631-68-5
Category:  

Natural Products Plants Moraceae Endogenous metabolite Human Gut Microbiota Metabolites Ficus carica L. Other Diseases Phenols Polyphenols Disease Research Fields

Target:  

Tyrosinase

3-(2,4-Dihydroxyphenyl) propanoic acid (DPPacid) is a competitive Tyrosinase inhibitor. It exhibits an IC50 value of 3.02 μM against mushroom tyrosinase with L-tyrosine as the substrate, an IC50 value of 62 μM with DL-DOPA as the substrate, and a Ki value of 11.5 μM. 3-(2,4-Dihydroxyphenyl) propanoic acid shows no DPPH radical scavenging activity. It can be used in studies related to ultraviolet B (UVB)-induced hyperpigmentation .
DL-Dopa
DL-Dopa
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Cat. No.: HY-113404
CAS No.: 63-84-3
Purity:  98.58%
Category:  

Ketones, Aldehydes, Acids Other Diseases Phenols Polyphenols Endogenous metabolite Disease Research Fields

Target:  

Tyrosinase Dopamine Receptor

DL-Dopa is a dopamine precursor. It serves as a substrate for Mushroom Tyrosinase, which oxidizes it to dopaquinone, an intermediate in the DOPA-melanin polymerization process, and this reaction can be detected at 475 nm. DL-Dopa also forms synergistic hydrophobic and π-π stacking interactions with cationic surfactants. Its binding to cetylpyridinium chloride (HY-B1464) is stronger and exhibits better thermodynamic stability than its binding to benzalkonium chloride (HY-B2232). DL-Dopa can compensate for dopamine depletion in the brain and is applicable to research related to Parkinson's disease .
3',4'-Dihydroxyacetophenone
3',4'-Dihydroxyacetophenone
0 Images
Cat. No.: HY-N1775
CAS No.: 1197-09-7
Synonyms: 3,4-DHAP
Category:  

Pinaceae Phenols Polyphenols Plants Picea schrenkiana Fisch. et Mey. Disease Research Fields Cancer

Target:  

Tyrosinase Reactive Oxygen Species (ROS) Keap1-Nrf2 PARP Autophagy Apoptosis

3',4'-Dihydroxyacetophenone (3,4-DHAP) is a phenolic compound with oral bioavailability, possessing potent antioxidant, anti-inflammatory, anticancer and cardiovascular protective activities. 3',4'-Dihydroxyacetophenone inhibits mushroom Tyrosinase activity with an IC50 of 10 μM, thereby suppressing melanogenesis . 3',4'-Dihydroxyacetophenone inhibits platelet aggregation in platelet-rich plasma. 3',4'-Dihydroxyacetophenone reduces ROS levels in human umbilical vein endothelial cells treated with high glucose, upregulates the expression of Nrf2, HO-1 and PARP-1 in cells, and promotes the nuclear translocation of Nrf2 . 3',4'-Dihydroxyacetophenone induces autophagy and apoptosis. 3',4'-Dihydroxyacetophenone inhibits seed germination/growth in most plants. 3',4'-Dihydroxyacetophenone can be used in the research of cancer, neurodegenerative diseases, non-alcoholic steatohepatitis, diabetes, obesity, skin pigmentation disorders, and cardiovascular and cerebrovascular diseases .
Assay Types