γ-Amanitin

Cat. No.: HY-131081: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

γ-Amanitin an ADC cytotoxin and isolated from the mushroom. γ-Amanitin inhibits RNA polymerase II and disrupts synthesis of mRNA. γ-Amanitin shows similar effects to α-Amanitin and β-Amanitin. γ-Amanitin competitively binds to monoclonal antibody (mAb), with an IC₅₀ of 163.1 ng/mL.

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γ-Amanitin Chemical Structure

CAS No. : 21150-23-2

Size	Stock
1 mg	Get quote	Estimated Time of Arrival: December 31
5 mg	Get quote	Estimated Time of Arrival: December 31
10 mg	Get quote	Estimated Time of Arrival: December 31
25 mg	Get quote	Estimated Time of Arrival: December 31
50 mg	Get quote	Estimated Time of Arrival: December 31

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This product is a controlled substance and not for sale in your territory.

Other Forms of γ-Amanitin:

α-Amanitin In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

Traditional Cytotoxic Agents

Molecular Weight

902.97

Formula

C₃₉H₅₄N₁₀O₁₃S

CAS No.

21150-23-2

Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=[S](C[C@H](NC(CNC1=O)=O)C(N[C@H](C2=O)CC(N)=O)=O)C(N3)=C(C[C@@H](C(NCC(N[C@H]1[C@@H](C)CC)=O)=O)NC([C@@H](NC([C@H](C4)N2C[C@@H]4O)=O)[C@@H](C)[C@@H](O)C)=O)C(C3=C5)=CC=C5O

Structure Classification

Initial Source

Microorganisms

Amanita phalloides var. alba mushroom

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Solution, -20°C, 2 years

Purity & Documentation

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (256 KB)

Handling Instructions (2659 KB)

References

[1]. He K, et al. Production of a broad-specificity monoclonal antibody and application as a receptor to detection amatoxins in mushroom. Biologicals. 2017 Sep;49:57-61. [Content Brief]

γ-Amanitin Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

γ-Amanitin21150-23-2DNA/RNA SynthesisADC CytotoxinADC PayloadmushroomADC cytotoxinRNA polymerase IImRNAprotein synthesisInhibitorinhibitorinhibit

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