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noncytotoxic

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41

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2

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5

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4

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2

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P1028
    Hexa-D-arginine
    5+ Cited Publications

    Furin Inhibitor II

    		 Bacterial Infection
    Hexa-D-arginine (Furin Inhibitor II) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo .
    Hexa-D-arginine
  • HY-120870
    para-Nitroblebbistatin
    2 Publications Verification

    		 Myosin Metabolic Disease
    para-Nitroblebbistatin is a derivative of Blebbistatin (HY-13813) and an inhibitor of myosin II. para-Nitroblebbistatin is photostable, non-cytotoxic, and non-phototoxic. para-Nitroblebbistatin can serve as an ideal substitute for Blebbistatin (HY-13813) to study the role of myosin II in physiology, development, and cell biology .
    para-Nitroblebbistatin
  • HY-101868
    INF39
    Maximum Cited Publications
    11 Publications Verification

    		 NOD-like Receptor (NLR) Inflammation/Immunology
    INF39 is an irreversible and noncytotoxic NLRP3 inhibitor.
    INF39
  • HY-157131
    TRPV2-selective blocker 1
    2 Publications Verification

    		 TRP Channel Neurological Disease
    TRPV2-selective blocker 1 is a TRPV2-selective blocker that inhibits calcium influx and ionic currents. TRPV2-selective blocker 1 exhibits an IC50 of 6.3 μM against rat TRPV2, and shows no activity against TRPV1, TRPV3 or TRPV4 channels. TRPV2-selective blocker 1 attenuates macrophage phagocytosis, LPS-induced macrophage migration, and calcium microdomains generated by peripheral TRPV2. TRPV2-selective blocker 1 is non-cytotoxic and can be used to investigate the function of TRPV2 during immune processes .
    TRPV2-selective blocker 1
  • HY-144012
    DPPE-PEG2000 ammonium

    16:0 PEG2000 PE ammonium; 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] ammonium

    		 Liposome Others
    DPPE-PEG2000 ammonium (16:0 PEG5000 PE) is a polymer-lipid conjugate and LipoParticle stabilizer with a PEG chain of 5,000 g/mol molecular weight attached to its polar head, and it can be internalized by biological membranes. DPPE-PEG2000 ammonium enables LipoParticle to maintain colloidal stability after 20-fold dilution in PBS or cell culture medium, and prevents aggregate formation during lyophilization and rehydration. DPPE-PEG2000 ammonium helps enhance the non-cytotoxic property of LipoParticle formulations against human osteoblasts. DPPE-PEG2000 ammonium serves as a PEG lipid functional end group for synthesizing liposomes (LPs), is used in the design of conjugated polymer nanoparticles, and applies to research related to bone and joint infections .
    DPPE-PEG2000 ammonium
  • HY-173496
    ST6GAL1-IN-1

    		Sialyltransferase Integrin VEGFR Akt Cancer
    ST6GAL1-IN-1 is an orally active selective ST6GAL1 inhibitor (IC50 = 20 μM). ST6GAL1-IN-1 exhibits high antimetastatic potential, effectively inhibiting the migration of MDA-MB-231 cells at noncytotoxic concentrations. ST6GAL1-IN-1 can disrupt integrin sialylation in MDA-MB-231 cells. ST6GAL1-IN-1 inhibits tumor angiogenesis and cancer metastasis via the Integrin/VEGFR2-mediated signaling pathway. ST6GAL1-IN-1 effectively suppresses both tumor growth and cancer metastasis on the MDA-MB-231 xenograft model. ST6GAL1-IN-1 can be used for the study of Triple-negative breast cancer (TNBC) .
    ST6GAL1-IN-1
  • HY-148560
    ccc_R08
    1 Publications Verification

    		 HBV DNA/RNA Synthesis Infection
    ccc_R08 is a non-cytotoxic and orally active cccDNA inhibitor that reduces cccDNA levels in the liver of HBV-infected mice. ccc_R08 can be used in the study of HBV virus (hepatitis B virus) infection .
    ccc_R08
  • HY-128062
    LIMK1 inhibitor BMS-4

    		LIM Kinase (LIMK) Cancer
    LIMK1 inhibitor BMS-4 is a LIM Kinase (LIMK) inhibitor targeting to LIMK1/2. LIMK1 inhibitor BMS-4 inhibits phosphorylation of cofilin, the LIMK substrate. However, LIMK1 inhibitor BMS-4 is noncytotoxic on A549 cells .
    LIMK1 inhibitor BMS-4
  • HY-144012H
    DPPE-PEG5000

    16:0 PEG5000 PE; 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-5000] ammonium

    		 Liposome Others
    DPPE-PEG5000 (16:0 PEG5000 PE) is a polymer-lipid conjugate and LipoParticle stabilizer with a PEG chain of 5,000 g/mol molecular weight attached to its polar head, and it can be internalized by biological membranes. DPPE-PEG5000 enables LipoParticle to maintain colloidal stability after 20-fold dilution in PBS or cell culture medium, and prevents aggregate formation during lyophilization and rehydration. DPPE-PEG5000 helps enhance the non-cytotoxic property of LipoParticle formulations against human osteoblasts. DPPE-PEG5000 serves as a PEG lipid functional end group for synthesizing liposomes (LPs), is used in the design of conjugated polymer nanoparticles, and applies to research related to bone and joint infections .
    DPPE-PEG5000
  • HY-145668
    Cyclopentenyl uracil

    		UGT Cancer
    Cyclopentenyl uracil, a non-cytotoxic inhibitor of uridine kinase, effectively blocks the salvage of circulating uridine by host and tumor tissues in the intact mouse .
    Cyclopentenyl uracil
  • HY-153016
    HIF-2α agonist 2
    1 Publications Verification

    		 HIF/HIF Prolyl-Hydroxylase Inflammation/Immunology
    HIF-2α agonist 2 (compound 10) is a HIF-2α agonist with an EC50 value of 1.68 μM at the dose of 20 μM. HIF-2α agonist 2 is non-cytotoxic against 786-O-HRE-Luc cells. HIF-2α agonist 2 can be used for oxygen metabolism research .
    HIF-2α agonist 2
  • HY-151369
    AV123

    		RIP kinase Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
    AV123 (compound 12) is a non-cytotoxic RIPK1 inhibitor (IC50=12.12 µM). AV123 blocks the TNF-α-induced necroptotic (EC50=1.7 μM) but not the apoptotic cell death. AV123 can be used in the study of necrotic chronic conditions such as ischemia-reperfusion injury of the brain, heart and kidney, inflammatory diseases, neurodegenerative diseases and infectious diseases .
    AV123
  • HY-128063
    CXCR3 antagonist 1

    		CXCR Inflammation/Immunology
    CXCR3 antagonist 1 (compound 6c) is a selective and non-cytotoxic CXCR3 antagonist (IC50=0.06 µM). CXCR3 antagonist 1 has potential in researching inflammatory diseases (including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and diabetes) .
    CXCR3 antagonist 1
  • HY-P1028A
    Hexa-D-arginine TFA
    5+ Cited Publications

    Furin Inhibitor II TFA

    		 Bacterial Infection
    Hexa-D-arginine TFA (Furin Inhibitor II TFA) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine TFA blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo .
    Hexa-D-arginine TFA
  • HY-W075353
    TPPS

    		Fluorescent Dye MOFs Cancer
    TPPS can be used as a non-cytotoxic probe for detecting tumor location .
    TPPS
  • HY-146727
    JAK3-IN-11

    		JAK Inflammation/Immunology
    JAK3-IN-11 (Compound 12), a potent, noncytotoxic, irreversible, orally active JAK3 inhibitor with IC50 value of 1.7 nM, has excellent selectivity (>588-fold compared to other JAK isoforms), covalently bind to the ATP-binding pocket in JAK3. JAK3-IN-11 strongly inhibits JAK3-dependent signaling and T cell proliferation, is a promising tool for study autoimmune diseases .
    JAK3-IN-11
  • HY-144655
    IP2

    		Phosphatase Cancer
    IP2 is an immunomodulatory agent. IP2 increases PTP (Pioneer Translation Product)-derived antigen presentation in cancer cells. IP2 shows non-cytotoxic for cancer cells. IP2 induces tumor growth defects in mouse .
    IP2
  • HY-157892
    Antimalarial agent 38

    		Parasite Infection
    Antimalarial agent 38 is an orally active antimalarial agent, which inhibits Plasmodium falciparum D6 strain, Chloroquine (HY-17589A)-sensitive Thai strain and Chloroquine-resistant FcB1 strain and K1 strain, with IC50s of 0.5, 13, 1 and 13 μM, respectively. Antimalarial agent 38 is non-cytotoxic for mammalian cells MCR58 (IC50 >140 μM). Antimalarial agent 38 improves the survival rate of Plasmodium yoelii nigeriensis infected mouse model .
    Antimalarial agent 38
  • HY-119938
    Tuberculosis inhibitor 1

    		Bacterial Infection
    Tuberculosis inhibitor 1 is a potent and non-cytotoxic trypanosoma brucei growth inhibitor with an EC50 of 5 nM .
    Tuberculosis inhibitor 1
  • HY-123228
    CHF5022

    		Amyloid-β Neurological Disease
    CHF5022 is an inhibitor of Aβ42 secretion (IC50=92 μM). CHF5022 retains a modest activity on Aβ40 at non-cytotoxic concentrations (−22.2±4.8% at 100 μM) .
    CHF5022
  • HY-N10437
    6-Acetylnimbandiol

    6-O-Acetylnimbandiol

    		 Tyrosinase Cancer
    6-Acetylnimbandiol (6-O-Acetylnimbandiol) is a non-cytotoxic tyrosinase inhibitor (IC50=69.85 μM) that effectively inhibits melanin production and MITF expression. 6-Acetylnimbandiol can be used in melanoma research .
    6-Acetylnimbandiol
  • HY-149698
    Tyrosinase-IN-17

    		Tyrosinase Cancer
    Tyrosinase-IN-17 (Compound 5b) is a lipophilic, skin-permeable, and non-cytotoxic Tyrosinase inhibitor (pIC50=4.99). Tyrosinase-IN-17 can be used for research on melanin-related diseases, such as melanoma, melanogenesis, etc .
    Tyrosinase-IN-17
  • HY-176401
    AChE-IN-87

    		Cholinesterase (ChE) Neurological Disease
    AChE-IN-87 (Compound 8j) is an AChE inhibitor (IC50: 0.05 μM; Ki: 16.93 nM). AChE-IN-87 is non-cytotoxic to 3T3 cells. AChE-IN-87 can be used in the study of Alzheimer's disease (AD) .
    AChE-IN-87
  • HY-170777
    SLU-10906

    		Parasite Infection
    SLU-10906 (Compound 63) is an orally active and potent Cryptosporidium inhibitor. SLU-10906 is active against the parasite in a cell-based infection model (EC50= 0.19 μM) and non-cytotoxic. SLU-10906 is promising for research of cryptosporidiosis .
    SLU-10906
  • HY-163630
    Antibacterial agent 217

    		Bacterial Infection
    Antibacterial agent 217 (Compound 24) is a non-cytotoxic, non-hemolytic, moderately active antibacterial agent that inhibits the growth of Staphylococcus aureus strains with a minimum inhibitory concentration (MIC) of 32 μg/mL. Antibacterial agent 217 also moderately inhibits the growth of Staphylococcus epidermidis .
    Antibacterial agent 217
  • HY-159582
    ACKR3 agonist 1

    		CXCR Cardiovascular Disease
    ACKR3 agonist 1 (compound 27) is a selective ACKR3 agonist (EC50=69 nM, Emax=82%) that inhibits platelet aggregation. ACKR3 agonist 1 is metabolically stable and non-cytotoxic, and has the potential to inhibit platelet-mediated thrombosis .
    ACKR3 agonist 1
  • HY-P10860
    cMCoFx1

    		Factor Xa Cardiovascular Disease
    cMCoFx1 is a potent and selective FXIIa cyclic peptide inhibitor. cMCoFx1 has high binding affinity (KD: 900 pM) and inhibitory activity (Ki: 370 pM) for FXIIa. cMCoFx1 can effectively inhibit endogenous clotting pathways, and cMCoFx1 is stable in serum and non-cytotoxic .
    cMCoFx1
  • HY-155105
    α-Glucosidase-IN-30

    		Glycosidase Metabolic Disease
    α-Glucosidase-IN-30 (compound 8c) is a potent, orally active, competitive inhibitor against α-glucosidase, with Ki  of 40.0 µM and IC50 value of 49.0 µM. α-Glucosidase-IN-30 is non-cytotoxic against the cancer and normal cell lines MCF-7 and HDF, and can be used for Type 2 diabetes study .
    α-Glucosidase-IN-30
  • HY-117512
    UWA-101 hydrochloride

    		Dopamine Transporter Serotonin Transporter Neurological Disease
    UWA-101 hydrochloride is a selective and non-cytotoxic DAT/SERT inhibitor, with EC50 values of 3.6 µM and 2.3 µM for inhibiting DAT and SERT, respectively. UWA-101 hydrochloride can alleviate the side effects of dopaminergic agents (such as L-DOPA), such as motor disorders, and lacks psychotropic activity. UWA-101 hydrochloride can be used for research on neurodegenerative diseases such as Parkinson's disease .
    UWA-101 hydrochloride
  • HY-155679
    SARS-CoV-2 nsp14-IN-4

    		SARS-CoV Infection
    SARS-CoV-2 nsp14-IN-4 (Compound 12q) is an inhibitor of SARS-CoV-2 nsp14 methyltransferase (IC50=19 nM). SARS-CoV-2 nsp14-IN-4 is non-cytotoxic and cell-permeable. SARS-CoV-2 nsp14-IN-4 is used in COVID-19 research .
    SARS-CoV-2 nsp14-IN-4
  • HY-161240
    MAO-B-IN-30

    		Monoamine Oxidase Neurological Disease Inflammation/Immunology
    MAO-B-IN-30 (compound IS7) is a potent, selective and cross the blood-brain barrier MAO-B inhibitor with IC50 values of 19.176, 0.082 µM for MAO-A and MAO-B, respectively. MAO-B-IN-30 shows antiproliferative activity and non-cytotoxic. MAO-B-IN-30 reduces TNF-alpha, IL-6, NF-kB levels. MAO-B-IN-30 has the potential for the research of Parkinson's disease .
    MAO-B-IN-30
  • HY-P11019
    IS4

    		CXCR Calcium Channel Cancer
    IS4 is a selective CXCR4 competitive antagonist, with an IC50 of 0.65 nM in THP-1 cells and 38.75 nM in Jurkat cells. IS4 is stable in serum and non-cytotoxic. IS4 competitively binds to CXCR4 with CXCL12, thereby inhibiting CXCL12-induced intracellular Ca 2+ release and cancer cell migration. IS4 can be used in the research on the prevention of metastasis of breast cancer, prostate cancer, leukemia, and other diseases .
    IS4
  • HY-170606
    α-Glucosidase-IN-79

    		Glycosidase Metabolic Disease
    α-Glucosidase-IN-79 (Compound 4d9) is a non-competitive α-Glucosidase inhibitor with an IC50 of 2.11 μM, which is more potent than existing α-Glucosidase inhibitors such as Acarbose (HY-B0089) (IC50 of 327.0 μM) and HXH8r (IC50 of 15.32 μM). α-Glucosidase-IN-79 is non-cytotoxic to human normal hepatocyte (LO2) cells and shows good metabolic stability in rat plasma. α-Glucosidase-IN-79 holds promise for research into type 2 diabetes .
    α-Glucosidase-IN-79
  • HY-117740
    Heronamide C

    		Others Others
    Heronamide C is a polyketide macrolactam isolated from marine Streptomyces that has the activity of producing reversible non-cytotoxic effects on mammalian cell morphology.
    Heronamide C
  • HY-101868R
    INF39 (Standard)

    		Reference Standards NOD-like Receptor (NLR) Inflammation/Immunology
    INF39 (Standard) is the analytical standard of INF39 (HY-101868). This product is intended for research and analytical applications. INF39 is an irreversible and noncytotoxic NLRP3 inhibitor.
    INF39 (Standard)
  • HY-186203
    8-Bromo-harmane

    		HSV Infection
    8-Bromo-harmane is a β-carboline derivative with anti-HSV-1 activity. 8-Bromo-harmane is non-cytotoxic. 8-Bromo-harmane can be used for the research of herpes simplex virus 1 (HSV-1) infection .
    8-Bromo-harmane
  • HY-126773
    Dp2mT

    		Biochemical Assay Reagents Infection
    Dp2mT is a non-cytotoxic control compound, with an IC50 of >3 μM for HIV-1 transcription inhibition and an IC50 of >10 μM for cytotoxicity. Dp2mT does not bind to intracellular iron pools. Dp2mT does not inhibit CDK9 activity .
    Dp2mT
  • HY-180275
    α-Glucosidase-IN-107

    		Glycosidase Inflammation/Immunology
    α-Glucosidase-IN-107 (Compound 1) is an α-glucosidase inhibitor with an IC50 of 1.01 μM. α-Glucosidase-IN-107 binds to the allosteric site of α-glucosidase. α-Glucosidase-IN-107 shows non-cytotoxic to normal lung fibrolast cells .
    α-Glucosidase-IN-107
  • HY-N17854
    3β-O-α-L-Arabinopyranosylsiaresinolic acid 28-O-β-D-glucopyranosyl ester

    		Drug Derivative Others
    3β-O-α-L-Arabinopyranosylsiaresinolic acid 28-O-β-D-glucopyranosyl ester is a triterpene glycoside found in the roots of Sanguisorba officinalis. 3β-O-α-L-Arabinopyranosylsiaresinolic acid 28-O-β-D-glucopyranosyl ester is non-cytotoxic and does not exhibit cytotoxic activity against human oral squamous cell carcinoma cells or normal human gingival fibroblasts .
    3β-O-α-L-Arabinopyranosylsiaresinolic acid 28-O-β-D-glucopyranosyl ester
  • HY-N17942
    3a-3,29-Dihydroxy-7-oxomultiflor-8-ene-3,29-diyldibenzoate

    		Others Cancer
    3a-3,29-Dihydroxy-7-oxomultiflor-8-ene-3,29-diyldibenzoate is a multiflorane triterpene ester found in the seeds of Trichosanthes kirilowii and non-cytotoxic agent.3a-3,29-Dihydroxy-7-oxomultiflor-8-ene-3,29-diyldibenzoate lacks marked cytotoxic activity against cancer cells .
    3a-3,29-Dihydroxy-7-oxomultiflor-8-ene-3,29-diyldibenzoate
  • HY-W035144
    5-(4-Carboxyphenyl)-10,15,20-triphenylporphyrin

    		HSV Drug Intermediate Infection
    5-(4-Carboxyphenyl)-10,15,20-triphenylporphyrin is a porphyrin compound. 5-(4-Carboxyphenyl)-10,15,20-triphenylporphyrin exhibits virucidal effects of 85% and 60% against HSV-1 and HSV-2, respectively. 5-(4-Carboxyphenyl)-10,15,20-triphenylporphyrin has a maximum noncytotoxic studied concentration of 5 μg/mL on Vero cells. 5-(4-Carboxyphenyl)-10,15,20-triphenylporphyrin can be used for the synthesis of compounds with stronger antiviral activity .
    5-(4-Carboxyphenyl)-10,15,20-triphenylporphyrin

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