142155-24-6
Chemical Structure
Gluten Exorphin A5
- CAS No.: 142155-24-6
- Formula:C29H37N5O9
- Molecular Weight:599.63
InChIKey: SBTRTGWXCQVLKM-VHEHYOFYSA-N
SMILES: OC(C=C1)=CC=C1C[C@H](NC([C@@H](NC(CN)=O)CC2=CC=C(C=C2)O)=O)C(N3[C@@H](CCC3)C(N[C@H](C(O)=O)[C@H](O)C)=O)=O
Biological Activity: Gluten Exorphin A5 is an orally active δ-opioid receptor ligand. Gluten Exorphin A5 exhibits opioid agonist biological activity, analgesic activity, stress-induced analgesia regulatory effects, memory-promoting effects, and non-cytotoxicity. Gluten Exorphin A5 modulates intestinal permeability, can cross in vitro human intestinal epithelial cells via paracellular transport, and resists brush border peptidase hydrolysis. Gluten Exorphin A5 can be used in the research of stress-related processes and cognitive processes[1][2][3].
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Gluten Exorphin A5 | Gluten Exorphin A5 is an orally active δ-opioid receptor ligand. Gluten Exorphin A5 exhibits opioid agonist biological activity, analgesic activity, stress-induced analgesia regulatory effects, memory-promoting effects, and non-cytotoxicity. Gluten Exorphin A5 modulates intestinal permeability, can cross in vitro human intestinal epithelial cells via paracellular transport, and resists brush border peptidase hydrolysis. Gluten Exorphin A5 can be used in the research of stress-related processes and cognitive processes. | |||||||||||||||||||||
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- [1]. Takahashi M, et al. Behavioral and pharmacological studies on gluten exorphin A5, a newly isolated bioactive food protein fragment, in mice. Japanese journal of pharmacology. 2000 Nov;84(3):259-65. [Content Brief]
- [2]. Maggioni M, et al. Transport of wheat gluten exorphins A5 and C5 through an in vitro model of intestinal epithelium. Food Research International.
- [3]. Stuknytė M, et al. Release of wheat gluten exorphins A5 and C5 during in vitro gastrointestinal digestion of bread and pasta and their absorption through an in vitro model of intestinal epithelium. Food Research International. 2015;72:208-214.
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