233605-81-7
233605-81-7
Chemical Structure
AV123
- CAS No.: 233605-81-7
- Formula:C11H14N4O2
- Molecular Weight:234.25
IUPAC Name: N-butyl-6-nitro-1H-benzo[d]imidazol-2-amine
InChIKey: KCMYEMHXIIFYLP-UHFFFAOYSA-N
SMILES: O=[N+](C1=CC=C2C(NC(NCCCC)=N2)=C1)[O-]
Biological Activity: AV123 (compound 12) is a non-cytotoxic RIPK1 inhibitor (IC50=12.12 µM). AV123 blocks the TNF-α-induced necroptotic (EC50=1.7 μM) but not the apoptotic cell death. AV123 can be used in the study of necrotic chronic conditions such as ischemia-reperfusion injury of the brain, heart and kidney, inflammatory diseases, neurodegenerative diseases and infectious diseases[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AV123 | 99.60% | AV123 (compound 12) is a non-cytotoxic RIPK1 inhibitor (IC50=12.12 µM). AV123 blocks the TNF-α-induced necroptotic (EC50=1.7 μM) but not the apoptotic cell death. AV123 can be used in the study of necrotic chronic conditions such as ischemia-reperfusion injury of the brain, heart and kidney, inflammatory diseases, neurodegenerative diseases and infectious diseases. | ||||||||||||||||||||
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