1. Others
  2. Others
  3. IP2

IP2 

Cat. No.: HY-144655
Handling Instructions

IP2 is an immunomodulatory agent. IP2 increases PTP (Pioneer Translation Product)-derived antigen presentation in cancer cells. IP2 shows non-cytotoxic for cancer cells. IP2 induces tumor growth defects in mouse.

For research use only. We do not sell to patients.

IP2 Chemical Structure

IP2 Chemical Structure

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

IP2 is an immunomodulatory agent. IP2 increases PTP (Pioneer Translation Product)-derived antigen presentation in cancer cells. IP2 shows non-cytotoxic for cancer cells. IP2 induces tumor growth defects in mouse[1].

In Vitro

IP2 (35 µM) shows immunomodulatory activity in murine MCA205 fibrosarcoma cells[1].
IP2 (35 µM) increases in the intron-derived SL8 antigen presentation[1].
IP2 (10 µM; 72 h) shows non-cytotoxic for cancer cells[1].
IP2 (10 µM) shows selectivity against three G-protein coupled receptor ADRB1 (35%), HRH2 (40%), and OPRD1 (53%), and inhibits the three enzymes of COX1 (52.8%), PDE3A (84.8%), and PDE4D2 (87.2%)[1].
IP2 (10 µM) dose not induce immunogenic cell death hallmarks in human osteosarcoma U2OS cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: MCF-7, A549, HCT116, K562, MCA205, B16F10, K562R, HUVEC cells
Concentration: 10 µM
Incubation Time: 72 h
Result: Showed non-cytotoxic for cancer cells.
In Vivo

IP2 (0.711 mg/kg for i.p. for mice; 9.103 mg/kg for i.v. for nice; 26.76 mg/kg for i.v. for dog) shows a high bioavailability in mice[1].
IP2 (50, 100, 250, 500 mg/kg; i.p.) shows very well toleration in C57BL/6 mice[1].
IP2 (2.5 mg/kg; i.v.) induces tumor growth defects in C57BL/6 mice[1].
IP2 (5 mg/kg; intratumor injection; three times per week for 2 weeks) induces tumor growth defects in C57BL/6 mice[1].
Pharmacokinetic Parameters of IP2 in Male C57BL/6J mice and male beagle dog[1].

Dose (mg/kg) Cmax (ng/mL) Tmax (h) T1/2 (h) CL (mL/min/kg) F % MRT0-t (h) AUCtot (ng/mL·h) AUCextra (%)
ip mice 9.103 2078 0.0833 0.8 154 86 0.7 982.3 1.3
iv mice 0.711 322.7 0.0833 1.1 133 0.9 88.8 15.2
iv dog 26.76 272 (µg/mL) 0.0833 3.8 0.69 3.8 654.7 (µg/mL·h) 0.9
Male C57BL/6J mice and male beagle dog; 0.711 mg/kg for i.p. for mice; 9.103 mg/kg for i.v. for mice; 26.76 mg/kg for i.v. for dog[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice and male beagle dog[1]
Dosage: 0.711 mg/kg for i.p. for mice; 9.103 mg/kg for i.v. for nice; 26.76 mg/kg for i.v. for dog
Administration: I.p. or i.v.
Result: Exhibited a high bioavailability in mice and a very low clearance in dogs and a moderate half-life of elimination.
Animal Model: Female C57BL/6 mice[1]
Dosage: 50, 100, 250, 500 mg/kg
Administration: I.p.
Result: Showed very well toleration in C57BL/6 mice.
Animal Model: C57BL/6 mice[1]
Dosage: 5 mg/kg
Administration: Intratumor injection; three times per week for 2 weeks
Result: Shows a 50% decreased in MCA205 WT fibrosarcoma growth at killing.
Molecular Weight

830.40

Formula

C32H20Na4O17P2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
IP2
Cat. No.:
HY-144655
Quantity:
MCE Japan Authorized Agent: