LIMK1 inhibitor BMS-4
Based on 1 Customer Validation
LIMK1 inhibitor BMS-4 is a LIM Kinase (LIMK) inhibitor targeting to LIMK1/2. LIMK1 inhibitor BMS-4 inhibits phosphorylation of cofilin, the LIMK substrate. However, LIMK1 inhibitor BMS-4 is noncytotoxic on A549 cells.
For research use only. We do not sell to patients.
- CAS No.: 905298-84-2
- Formula: C23H23N7O2S
- Molecular Weight:461.54
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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LIMK1 7.25 (pIC50) |
LIMK2 6.87 (pIC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-1080 | IC50 |
>50 μM
Compound: 31
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Cytotoxicity against human HT1080 cells assessed as inhibition of thymidine incorporation
Cytotoxicity against human HT1080 cells assessed as inhibition of thymidine incorporation
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[PMID: 22902653] |
| ZR-75-1 | IC50 |
1 nM
Compound: BMS4
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Inhibition of LIMK1-catalyzed cofilin phosphorylation in human ZR-75-1 cells
Inhibition of LIMK1-catalyzed cofilin phosphorylation in human ZR-75-1 cells
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10.1039/C1MD00138H |
LIMK1 inhibitor BMS-4 (compound 4) (0.014-10 μM; 24 h) inhibits LIMKs in vitro without affecting A549 cell survival or proliferation[1].
LIMK1 inhibitor BMS-4 (0.014-1 μM; 2 h) inhibits phosphorylation of the LIMK substrate cofilin in A549 human lung cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 905298-84-2
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Appearance Solid
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Molecular Weight 461.54
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Formula C23H23N7O2S
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Color White to off-white
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SMILES
O=C(NCC)NC1=NC=C(C2=CC(C3=C(C)C=C(C=C3C)OC)=NC(C4=NC=CN=C4)=N2)S1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Collins R, et al. Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity. J Med Chem. 2022 Oct 27;65(20):13705-13713. [Content Brief]
[2]. Ross-Macdonald P, et al. Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors. Mol Cancer Ther. 2008 Nov;7(11):3490-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LIMK1 inhibitor BMS-4 Related Classifications
HY-128062 Related Classifications
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