LIMK-IN-1
Based on 1 Customer Validation
LIMK-IN-1 (Compound 14) is an inhibitor of LIM-Kinase (LIMK), with IC50s of 0.5 nM and 0.9 nM for LIMK1 and LIMK2, respectively. LIMK-IN-1 can be used for ocular hypertension and associated glaucoma research.
For research use only. We do not sell to patients.
- Purity: 99.33%
- CAS No.: 1116571-01-7
- Formula: C20H21BrN8
- Molecular Weight:453.34
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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LIMK1 0.9 nM (IC50) |
LIMK2 0.5 nM (IC50) |
ROCK1 260 nM (IC50) |
ROCK2 2700 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| Sf9 | IC50 |
0.9 nM
Compound: 14
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Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation counting
Inhibition of human recombinant LIMK2 expressed in baculovirus-Sf9 system by scintillation counting
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[PMID: 19831390] |
LIMK-IN-1 (Compound 14) (100 nM) increases outflow facility by about 30% in a pig eye perfusion assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1116571-01-7
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Appearance Solid
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Molecular Weight 453.34
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Formula C20H21BrN8
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Color White to off-white
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SMILES
CC1=CNC2=NC=NC(N3C[C@H](C)N(/C(NC4=CC=CC(Br)=C4)=N\C#N)CC3)=C21
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 125 mg/mL (275.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2058 mL | 11.0292 mL | 22.0585 mL | 55.1462 mL |
| 5 mM | 0.4412 mL | 2.2058 mL | 4.4117 mL | 11.0292 mL | |
| 10 mM | 0.2206 mL | 1.1029 mL | 2.2058 mL | 5.5146 mL | |
| 15 mM | 0.1471 mL | 0.7353 mL | 1.4706 mL | 3.6764 mL | |
| 20 mM | 0.1103 mL | 0.5515 mL | 1.1029 mL | 2.7573 mL | |
| 25 mM | 0.0882 mL | 0.4412 mL | 0.8823 mL | 2.2058 mL | |
| 30 mM | 0.0735 mL | 0.3676 mL | 0.7353 mL | 1.8382 mL | |
| 40 mM | 0.0551 mL | 0.2757 mL | 0.5515 mL | 1.3787 mL | |
| 50 mM | 0.0441 mL | 0.2206 mL | 0.4412 mL | 1.1029 mL | |
| 60 mM | 0.0368 mL | 0.1838 mL | 0.3676 mL | 0.9191 mL | |
| 80 mM | 0.0276 mL | 0.1379 mL | 0.2757 mL | 0.6893 mL | |
| 100 mM | 0.0221 mL | 0.1103 mL | 0.2206 mL | 0.5515 mL |
LIMK-IN-1 Related Classifications
HY-14227 Related Classifications
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