905298-84-2
905298-84-2
Chemical Structure
LIMK1 inhibitor BMS-4
- CAS No.: 905298-84-2
- Formula:C23H23N7O2S
- Molecular Weight:461.54
IUPAC Name: 1-ethyl-3-(5-(6-(4-methoxy-2,6-dimethylphenyl)-2-(pyrazin-2-yl)pyrimidin-4-yl)thiazol-2-yl)urea
InChIKey: WUCYRTXFXRZKSV-UHFFFAOYSA-N
SMILES: O=C(NCC)NC1=NC=C(C2=CC(C3=C(C)C=C(C=C3C)OC)=NC(C4=NC=CN=C4)=N2)S1
Biological Activity: LIMK1 inhibitor BMS-4 is a LIM Kinase (LIMK) inhibitor targeting to LIMK1/2. LIMK1 inhibitor BMS-4 inhibits phosphorylation of cofilin, the LIMK substrate. However, LIMK1 inhibitor BMS-4 is noncytotoxic on A549 cells[1][2].
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LIMK1 inhibitor BMS-4 | LIMK1 inhibitor BMS-4 is a LIM Kinase (LIMK) inhibitor targeting to LIMK1/2. LIMK1 inhibitor BMS-4 inhibits phosphorylation of cofilin, the LIMK substrate. However, LIMK1 inhibitor BMS-4 is noncytotoxic on A549 cells. | |||||||||||||||||||||
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References
- [1]. Collins R, et al. Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity. J Med Chem. 2022 Oct 27;65(20):13705-13713. [Content Brief]
- [2]. Ross-Macdonald P, et al. Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors. Mol Cancer Ther. 2008 Nov;7(11):3490-8. [Content Brief]
Keywords
