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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
phosphodiesterase 7
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "phosphodiesterase 7" in MCE Product Catalog:
1
1 Cited Publications
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PDE7-IN-2 (compound 2) is a potent PDE7 (phosphodiesterase 7) inhibitor with IC50 value of 2.1 µM. PDE7-IN-2 has the potential for the research of parkinson’s disease .
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PDE7-IN-4 is a phosphodiesterase 7 (PDE7) inhibitor with activity that increases intracellular cyclic adenosine monophosphate (cAMP) levels. PDE7-IN-4 shows potential inhibitory effects in neurotransmission and anti-inflammatory applications. PDE7-IN-4 exerts its biological activity by acting on the cAMP/cAMP response element binding protein (CREB) pathway. The development of PDE7-IN-4 aims to improve its pharmacokinetic characteristics to more effectively target neurodegenerative diseases and other inflammation-related diseases .
Cat. No.: HY-P2424
CAS No.: 144396-38-3
Synonyms: CCK-J
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Cat. No.: HY-P703577
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PDE7A; High Affinity CAMP-Specific PDE 1; phosphodiesterase 7A; TM22; HCP1; High Affinity CAMP-Specific 3',5'-Cyclic phosphodiesterase 7A; High Affinity 3',5'-Cyclic-AMP phosphodiesterase 7A; phosphodiesterase Isozyme 7; CAMP-Specific phosphodiesterase 7A
Species:
Human
Source:
E. coli
Cat. No.: HY-P76902
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ENPP7; Alkaline Sphingomyelin phosphodiesterase; Ectonucleotide Pyrophosphatase/phosphodiesterase 7; Intestinal Alkaline Sphingomyelinase; Alk-SMase; Alkaline Sphingomyelinase; NPP7; E-NPP 7; Ectonucleotide Pyrophosphatase/phosphodiesterase Family Member
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P77358
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ENPP7; Alkaline Sphingomyelin phosphodiesterase; Ectonucleotide Pyrophosphatase/phosphodiesterase 7; Intestinal Alkaline Sphingomyelinase; Alk-SMase; Alkaline Sphingomyelinase; NPP7; E-NPP 7; Ectonucleotide Pyrophosphatase/phosphodiesterase Family Member
Species:
Human
Source:
HEK293
Cat. No.: HY-119514
CAS No.: 423744-89-2
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BC12 is a barbituric acid derivative and a phosphodiesterase 7 (PDE7) inhibitor, with an IC50 of 0.77 μM against human targets. BC12 inhibits the enzymatic activity of PDE7, but this activity is not the driver of its immunomodulatory effects on T lymphocytes. BC12 blocks the upregulation of IL-2 transcription in activated T cells. BC12 modulates the transcriptional response of T cells upon stimulation, exerting anti-inflammatory and pro-stress effects. BC12 inhibits the proliferation of primary mouse T cells and the IL-2 secretion of human peripheral blood T lymphocytes. BC12 exerts immunosuppressive and immunomodulatory effects on T lymphocyte function. BC12 can be used in research related to T lymphocyte-mediated diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
