4 Results for "

photothermal agent

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "photothermal agent" in MCE Product Catalog:

7
IR-780
IR-780
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7 Cited Publications
Cat. No.: HY-D1063
CAS No.: 207399-07-3
IR-780 is a near-infrared fluorescent probe for in vivo imaging of tumor cells. IR-780 is transported into tumor cells via OATPs and ABCB10, with uptake dependent on glycolytic activity and plasma membrane potential. IR-780 preferentially accumulates in tumor cell mitochondria, including those of drug-resistant cancer cells, without chemical conjugation. IR-780 generates reactive oxygen species (ROS), induces hyperthermia and apoptosis, inhibits tumor growth and recurrence, and modulates HSP70 expression upon ultrasound or 808 nm laser exposure. IR-780 acts as a sonosensitizer, photodynamic and photothermal agent, and drug delivery carrier, with low acute imaging-dose toxicity and rapid vital organ clearance. IR-780 can be used for the research of cancer, such as breast cancer, lung cancer, and non-small cell lung cancer (NSCLC) .
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IR-1048
IR-1048
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Cat. No.: HY-D1450
CAS No.: 155613-98-2
Synonyms: S01448
Target:  

Fluorescent Dye

Research Areas:  

Cancer

IR-1048 is a nitroreductase (NTR)-responsive near-infrared fluorescence (NIR)/photoacoustic (PA) imaging probe and photothermal agent. IR-1048 is coupled with a nitroimidazole group to form IR-1048-MZ. IR-1048-MZ is catalytically reduced by NTR in a hypoxic environment, restoring strong near-infrared absorption and fluorescence emission (NIR II window), while activating the photothermal effect. IR-1048 relies on NTR-mediated electron transfer to relieve intramolecular fluorescence quenching, achieving specific imaging and photothermal ablation of tumor hypoxic areas. IR-1048 is mainly used for high-contrast NIR II/photoacoustic imaging and photothermal therapy research and tumor diagnosis of the tumor hypoxic microenvironment .
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IR-775 chloride
IR-775 chloride
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Cat. No.: HY-W248590
CAS No.: 199444-11-6
IR-775 chloride is a cyanine dye with near-infrared absorption (Ex/Em = 775/795 nm). IR-775 chloride acts as a photosensitizer or photothermal agent, and induces apoptosis via generating ROS or exerting photothermal effects upon irradiation; its combination with 2-methoxyestradiol (HY-12033) inhibits SOD2 to enhance photodynamic therapy (PDT) efficacy, and its liposomal encapsulation enables phytotherapy-photothermal therapy (PTT) synergy. IR-775 chloride is applicable for investigating PDT/PTT and near-infrared fluorescence imaging in ovarian cancer and breast cancer .
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BSS-Et
BSS-Et
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Cat. No.: HY-184451
CAS No.: 2825003-94-7
Target:  

Photosensitizer Reactive Oxygen Species (ROS) DNA/RNA Synthesis Apoptosis

Research Areas:  

Cancer

BSS-Et is a near-infrared phototheranostic agent that serves as one of the two release units of hypoxia-responsive prodrug BNNC, responsible for generating photodynamic therapy (PDT) and photothermal therapy (PTT) effects at tumor sites. BSS-Et produces reactive oxygen species and singlet oxygen upon irradiation, inducing oxidative stress and DNA damage. When combined with (R)-CR8 (HY-18340), BSS-Et enhances DNA damage and apoptosis in breast cancer cells. BSS-Et can be used in breast cancer-related research .
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