199444-11-6
Chemical Structure
IR-775 chloride
- CAS No.: 199444-11-6
- Formula:C32H36Cl2N2
- Molecular Weight:519.55
IUPAC Name: 7-(diethylamino)-3-(thiophen-2-yl)-2H-chromen-2-one
InChIKey: BPSIJFMUSNMMAL-UHFFFAOYSA-M
SMILES: CC1(C)C(/C=C/C2=C(Cl)/C(CCC2)=C/C=C3N(C)C4=C(C=CC=C4)C/3(C)C)=[N+](C)C5=C1C=CC=C5.[Cl-]
Biological Activity: IR-775 chloride is a cyanine dye with near-infrared absorption (Ex/Em = 775/795 nm). IR-775 chloride acts as a photosensitizer or photothermal agent, and induces apoptosis via generating ROS or exerting photothermal effects upon irradiation; its combination with 2-methoxyestradiol (HY-12033) inhibits SOD2 to enhance photodynamic therapy (PDT) efficacy, and its liposomal encapsulation enables phytotherapy-photothermal therapy (PTT) synergy. IR-775 chloride is applicable for investigating PDT/PTT and near-infrared fluorescence imaging in ovarian cancer and breast cancer[1][2].
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IR-775 chloride | IR-775 chloride is a cyanine dye with near-infrared absorption (Ex/Em = 775/795 nm). IR-775 chloride acts as a photosensitizer or photothermal agent, and induces apoptosis via generating ROS or exerting photothermal effects upon irradiation; its combination with 2-methoxyestradiol (HY-12033) inhibits SOD2 to enhance photodynamic therapy (PDT) efficacy, and its liposomal encapsulation enables phytotherapy-photothermal therapy (PTT) synergy. IR-775 chloride is applicable for investigating PDT/PTT and near-infrared fluorescence imaging in ovarian cancer and breast cancer. | |||||||||||||||||||||
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- [1]. Waszkiewicz M, et al. The photodynamic reaction with IR-775 cyanine combined with 2-methoxyestradiol in ovarian (SKOV-3) and human breast adenocarcinoma (MDA MB-231) cell lines. Photodiagnosis and photodynamic therapy. 2022 Jun;38:102766. [Content Brief]
- [2]. Pebam M, et al. IR-775 - Hyptis loaded bioactive nanoparticles for enhanced phyto-photothermal therapy of breast cancer cells. Photodiagnosis and photodynamic therapy. 2023 Dec;44:103872. [Content Brief]
Keywords
