155613-98-2
Chemical Structure
IR-1048
Synonym(s): S01448
- CAS 番号: 155613-98-2
- Formula:C40H38BCl3F4N2
- Molecular Weight:739.91
InChIKey: IKZNCEDZIQWVNS-UHFFFAOYSA-N
SMILES: [F-][B+3]([F-])([F-])[F-].ClC1=CC=C2C3=C(/C(N2CCCC)=C\C=C4C(Cl)=C(CCC\4)/C=C/C5=[N+](CCCC)C6=CC=C(Cl)C7=CC=CC5=C67)C=CC=C31
Biological Activity: IR-1048 is a nitroreductase (NTR)-responsive near-infrared fluorescence (NIR)/photoacoustic (PA) imaging probe and photothermal agent. IR-1048 is coupled with a nitroimidazole group to form IR-1048-MZ. IR-1048-MZ is catalytically reduced by NTR in a hypoxic environment, restoring strong near-infrared absorption and fluorescence emission (NIR II window), while activating the photothermal effect. IR-1048 relies on NTR-mediated electron transfer to relieve intramolecular fluorescence quenching, achieving specific imaging and photothermal ablation of tumor hypoxic areas. IR-1048 is mainly used for high-contrast NIR II/photoacoustic imaging and photothermal therapy research and tumor diagnosis of the tumor hypoxic microenvironment[1][2].
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IR-1048 | 97.0% | IR-1048 is a nitroreductase (NTR)-responsive near-infrared fluorescence (NIR)/photoacoustic (PA) imaging probe and photothermal agent. IR-1048 is coupled with a nitroimidazole group to form IR-1048-MZ. IR-1048-MZ is catalytically reduced by NTR in a hypoxic environment, restoring strong near-infrared absorption and fluorescence emission (NIR II window), while activating the photothermal effect. IR-1048 relies on NTR-mediated electron transfer to relieve intramolecular fluorescence quenching, achieving specific imaging and photothermal ablation of tumor hypoxic areas. IR-1048 is mainly used for high-contrast NIR II/photoacoustic imaging and photothermal therapy research and tumor diagnosis of the tumor hypoxic microenvironment. | ||||||||||||||||||||
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References
- [1]. Xiaoqing Meng, et al. Hypoxia-triggered single molecule probe for high-contrast NIR II/PA tumor imaging and robust photothermal therapy. Theranostics. 2018 Nov 15;8(21):6025-6034. [Content Brief]
- [2]. Xiaoxu Kang, et al. Dual-Cascade Responsive Nanoparticles Enhance Pancreatic Cancer Therapy by Eliminating Tumor-Resident Intracellular Bacteria. Adv Mater. 2022 Dec;34(49):e2206765. [Content Brief]
