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Results for "

pigmentation

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (1) Antibiotic (1) AP-1 (1) Apoptosis (1) Autophagy (2) Bacterial (2) Biochemical Assay Reagents (3) Cholinesterase (ChE) (1) Drug Derivative (3) Endogenous Metabolite (2) Glycosidase (1) GSK-3 (1) Insecticide (1) Keap1-Nrf2 (1) Melanocortin Receptor (8) Nuclear Factor of activated T Cells (NFAT) (1) PARP (1) Reactive Oxygen Species (ROS) (2) Reference Standards (1) Ser/Thr Protease (1) Sirtuin (2) Tyrosinase (12)
By Research Areas:	Cancer (8) Cardiovascular Disease (1) Endocrinology (5) Infection (2) Inflammation/Immunology (7) Metabolic Disease (18) Neurological Disease (3)

By Targets:

AMPK (1)

Antibiotic (1)

AP-1 (1)

Apoptosis (1)

Autophagy (2)

Bacterial (2)

Biochemical Assay Reagents (3)

Cholinesterase (ChE) (1)

Drug Derivative (3)

Endogenous Metabolite (2)

Glycosidase (1)

GSK-3 (1)

Insecticide (1)

Keap1-Nrf2 (1)

Melanocortin Receptor (8)

Nuclear Factor of activated T Cells (NFAT) (1)

PARP (1)

Reactive Oxygen Species (ROS) (2)

Reference Standards (1)

Ser/Thr Protease (1)

Sirtuin (2)

Tyrosinase (12)

By Research Areas:

Cancer (8)

Cardiovascular Disease (1)

Endocrinology (5)

Infection (2)

Inflammation/Immunology (7)

Metabolic Disease (18)

Neurological Disease (3)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-125860

Tyrosinase, Mushroom Polyphenol oxidase	Tyrosinase	Neurological Disease Endocrinology Cancer
Tyrosinase (EC 1.14.18.1) (Polyphenol oxidase) is a rate-limiting enzyme that controls the production of melanin. Tyrosinase is mainly found in melanosomes synthesized by skin melanocytes. Tyrosinase can be used in research on Parkinson's disease, melanoma and pigmentation .

HY-109114

Dersimelagon MT-7117	Melanocortin Receptor	Metabolic Disease
Dersimelagon (MT-7117) is an orally active, selective melanocortin 1 receptor (MC1R) agonist with EC₅₀ values of 8.16, 3.91, 1.14 and 0.251 nM for human (h), cynomolgus monkey (cm), mouse (m) and rat (r) MC1R, respectively. Dersimelagon shows good affinity for hMC1R and hMC4R with K_i values of 2.26, 32.9 nM, respectively. Dersimelagon can be used for the research of skin pigmentation .

HY-W251181

Isobutylamido thiazolyl resorcinol	Tyrosinase	Metabolic Disease
Isobutylamido thiazolyl resorcinol is a selective hTyr inhibitor with an IC₅₀ of 1.1 μM. Isobutylamido thiazolyl resorcinol shows an IC₅₀ of 108 μM against mushroom Tyrosinase. Isobutylamido thiazolyl resorcinol effectively prevents pigmentation caused by UVB irradiation. Isobutylamido thiazolyl resorcinol significantly improves the visibility of acne-induced hyperpigmentation .

HY-P0097

Nonapeptide-1 2 Publications Verification Melanostatine-5	Melanocortin Receptor	Metabolic Disease Endocrinology Cancer
Nonapeptide-1 (Melanostatine-5), a peptide hormone, is a selective antagonist of MC1R (K_i: 40 nM). Nonapeptide-1 is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC₅₀: 2.5 nM and 11 nM, respectively). Nonapeptide-1 inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer .

HY-P10533

Cysteine peptide	Tyrosinase	Others
Cysteine peptide is a tyrosinase inhibitor with skin-whitening, antioxidant and multi-regulatory activities. Cysteine peptide inhibits enzyme activity and blocks melanin transport, effectively reducing UV-B-induced skin erythema and pigmentation. Cysteine peptide synergistically maintains skin health by quenching ROS, resisting oxidative stress and promoting pheomelanin production. Cysteine peptide safely prevents daily ultraviolet damage and supports moderate sun exposure for vitamin D synthesis. Cysteine peptide also acts as a plant signaling factor to regulate vegetative growth, development and stress resistance responses .

HY-20074

(+)-Pinanediol (1S,2S,3R,5S)-(+)-Pinanediol	Biochemical Assay Reagents	Others
(+)-Pinanediol ((1S,2S,3R,5S)-(+)-Pinanediol) is a potent inducer of melanin production. In S91 cells, it acts by inducing higher levels of pigmentation and nitric oxide (NO) synthesis .

HY-W015591

Mandelic acid 1 Publications Verification (±)-Mandelic acid; DL-Mandelic acid	Bacterial Endogenous Metabolite	Infection
Mandelic acid ((±)-Mandelic acid), an alpha-hydroxycarboxylic acid, has been widely used as an intermediate of pharmaceutical and fine chemicals. Mandelic acid shows antimicrobial activity and has been used for the research of urinary tract infections and vaginal trichomoniasis. Mandelic acid exhibits high sperm-immobilizing activity and low vaginal irritation .

HY-N2204

Swertiajaponin	Tyrosinase Reactive Oxygen Species (ROS)	Inflammation/Immunology
Swertiajaponin is a tyrosinase inhibitor, forms multiple hydrogen bonds and hydrophobic interactions with the binding pocket of tyrosinase, with an IC₅₀ of 43.47 μM. Swertiajaponin also inhibits oxidative stress-mediated MAPK/MITF signaling, leading to decrease in tyrosinase protein level. Swertiajaponin suppresses melanin accumulation and exhibits strong anti-oxidative activity .

HY-N1775

3',4'-Dihydroxyacetophenone 3,4-DHAP	Tyrosinase Reactive Oxygen Species (ROS) Keap1-Nrf2 PARP Autophagy Apoptosis	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
3',4'-Dihydroxyacetophenone (3,4-DHAP) is a phenolic compound with oral bioavailability, possessing potent antioxidant, anti-inflammatory, anticancer and cardiovascular protective activities. 3',4'-Dihydroxyacetophenone inhibits mushroom Tyrosinase activity with an IC₅₀ of 10 μM, thereby suppressing melanogenesis . 3',4'-Dihydroxyacetophenone inhibits platelet aggregation in platelet-rich plasma. 3',4'-Dihydroxyacetophenone reduces ROS levels in human umbilical vein endothelial cells treated with high glucose, upregulates the expression of Nrf2, HO-1 and PARP-1 in cells, and promotes the nuclear translocation of Nrf2 . 3',4'-Dihydroxyacetophenone induces autophagy and apoptosis. 3',4'-Dihydroxyacetophenone inhibits seed germination/growth in most plants. 3',4'-Dihydroxyacetophenone can be used in the research of cancer, neurodegenerative diseases, non-alcoholic steatohepatitis, diabetes, obesity, skin pigmentation disorders, and cardiovascular and cerebrovascular diseases .

HY-P0097A

Nonapeptide-1 acetate salt 2 Publications Verification Melanostatine-5 acetate salt	Melanocortin Receptor	Metabolic Disease Endocrinology Cancer
Nonapeptide-1 (Melanostatine-5) acetate salt, a peptide hormone, is a selective antagonist of MC1R (K_i: 40 nM). Nonapeptide-1 acetate salt is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes (IC₅₀: 2.5 nM and 11 nM, respectively). Nonapeptide-1 acetate salt inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer .

HY-P5247

Palmitoyl tetrapeptide-20 PTP20	Melanocortin Receptor Sirtuin	Metabolic Disease Inflammation/Immunology
Palmitoyl tetrapeptide-20 (PTP20) is a biomimetic peptide agonist of α-MSH. Palmitoyl tetrapeptide-20 promotes hair pigmentation and delays hair graying by activating the MC1-R pathway (AC₅₀: 0.16 nM), enhancing catalase activity to reduce H₂O₂ accumulation, and upregulating SIRT1 activity. Palmitoyl tetrapeptide-20 can be used in research on preventing hair loss and improving hair graying .

HY-78700

4-Bromobenzoic acid	Tyrosinase	Metabolic Disease
4-Bromobenzoic acid is a tyrosinase inhibitor (IC₅₀ range 0-0.3 mg/mL). 4-Bromobenzoic acid can be metabolized through the protocatechuic acid (PCA) pathway. 4-Bromobenzoic acid can be used for research on cosmetic whitening or pigmentation conditions .

HY-W250145

Acid Black 2 Nigrosine	Biochemical Assay Reagents	Others
Acid Black 2 (Nigrosine) is an alcohol-soluble absorber used to mimic skin pigmentation in tissue-mimicking phantoms. Acid Black 2 acts as an absorber in silicone-based thin tissue phantoms to simulate varying melanosome volume fractions in skin .

HY-N12267

N,N′-Diferuloylputrescine (E/Z)-Terrestribisamide	Melanocortin Receptor	Metabolic Disease
N,N′-Diferuloylputrescine ((E/Z)-Terrestribisamide) is a inhibitor of *pigmentation* with 57% reduction. N,N′-Diferuloylputrescine significantly reduces the protein level of MITF. N,N′-Diferuloylputrescine has strong antioxidant activities as radical scavengers against reactive oxygen species .

HY-P5247A

Palmitoyl tetrapeptide-20 TFA PTP20 TFA	Melanocortin Receptor Sirtuin	Metabolic Disease Inflammation/Immunology
Palmitoyl tetrapeptide-20 (PTP20) TFA is a biomimetic peptide agonist of α-MSH. Palmitoyl tetrapeptide-20 TFA promotes hair pigmentation and delays hair graying by activating the MC1-R pathway (AC₅₀: 0.16 nM), enhancing catalase activity to reduce H₂O₂ accumulation, and upregulating SIRT1 activity. Palmitoyl tetrapeptide-20 TFA can be used in research on preventing hair loss and improving hair graying .

HY-W015591R

Mandelic acid (Standard) (±)-Mandelic acid (Standard); DL-Mandelic acid (Standard)	Reference Standards Bacterial Endogenous Metabolite	Infection
Mandelic acid (Standard) is the analytical standard of Mandelic acid. This product is intended for research and analytical applications. Mandelic acid ((±)-Mandelic acid), an alpha-hydroxycarboxylic acid, has been widely used as an intermediate of pharmaceutical and fine chemicals. Mandelic acid shows antimicrobial activity and has been used for the research of urinary tract infections and vaginal trichomoniasis. Mandelic acid exhibits high sperm-immobilizing activity and low vaginal irritation .

HY-116640

Amorphigenin	AP-1 Nuclear Factor of activated T Cells (NFAT) AMPK Autophagy	Metabolic Disease Inflammation/Immunology Endocrinology
Amorphigenin is a trothotenone compound. Amorphigenin inhibits osteoclast differentiation by suppressing the expression of c-Fos and NFATc1 in activated T cells. Amorphigenin degrades melanosome proteins by activating the AMPK-dependent autophagy pathway, but not in dependence of the mTOR pathway. Amorphigenin significantly protects bone mass and reduces bone erosion in a mouse model of inflammatory bone loss. Amorphigenin can be used to study inflammatory bone diseases, postmenopausal osteoporosis, and skin pigmentation disorders .

HY-148400

Cetyl tranexamate hydrochloride TXC hydrochloride	Ser/Thr Protease Drug Derivative	Metabolic Disease
Cetyl tranexamate (TXC) hydrochloride is an ester derivative of Tranexamic acid (HY-B0149). Cetyl tranexamate hydrochloride is an inhibitor of fibrinogen activation and can reduce the production of fibrinogen in keratinocytes induced by ultraviolet rays or damage, indirectly inhibiting the melanin production pathway. Cetyl tranexamate hydrochloride also targets melanin (dark spots) and hemoglobin (red spots), reducing vascular dilation and pigmentation by inhibiting inflammatory mediators (such as prostaglandins, platelet activating factors). Cetyl tranexamate hydrochloride can be used as a cosmetic ingredient and is suitable for epidermal pigment disorders such as photoaging, post-inflammatory hyperpigmentation (PIH), and melasma .

HY-W068430

5,7-Dimethoxy-2,2-dimethylchromene	Insecticide	Others
5,7-Dimethoxy-2,2-dimethylchromene is a synthetic precocenoid, has potential insect control function. 5,7-Dimethoxy-2,2-dimethylchromene induces loss of pigmentation in hatching larvae of shield bug (Eurgaster integriceps) .

HY-109114A

Dersimelagon phosphate MT-7117 phosphate	Melanocortin Receptor	Metabolic Disease
Dersimelagon phosphate is an orally active, selective melanocortin 1 receptor (MC1R) agonist with EC₅₀ values of 8.16, 3.91, 1.14 and 0.251 nM for human (h), cynomolgus monkey (cm), mouse (m) and rat (r) MC1R, respectively. Dersimelagon phosphate shows good affinity for hMC1R and hMC4R with K_i values of 2.26, 32.9 nM, respectively. Dersimelagon phosphate can be used for the research of skin pigmentation .

HY-121889

FQ	Tyrosinase	Inflammation/Immunology
FQ is a tyrosinase inhibitor that effectively inhibits the diphenolase activity of mushroom tyrosinase (IC₅₀=120 μM). FQ can be used in the study of pigmentation .

HY-173512

mTYR-IN-1	Tyrosinase	Metabolic Disease
mTYR-IN-1 (compound 3e) is a reversible and competitive mTYR inhibitor with an IC₅₀ of 4.86 μM. mTYR-IN-1 can be used in the study of skin pigmentation .

HY-177607

25-Flurocholesterol	Biochemical Assay Reagents	Metabolic Disease
25-Flurocholesterol is an oxysterol. 25-Fluorocholesterol increases pigmentation .

HY-161969

Tyrosinase-IN-34	Tyrosinase	Cancer
Tyrosinase-IN-34 (compound 5a) is a human tyrosinase inhibitor (IC₅₀: 3.5 μM) with the potential to control melanogenesis and pigmentation .

HY-W267446

6-Methoxy-4-methylcoumarin	Melanocortin Receptor GSK-3	Metabolic Disease Cancer
6-Methoxy-4-methylcoumarin is a 4-methylcoumarin derivative with an antitumor activity. 6-Methoxy-4-methylcoumarin activates melanin synthesis in B16F10 melanoma cells. 6-Methoxy-4-methylcoumarin is a pigmentation stimulator, and can be used for the study of skin conditions such as vitiligo .

HY-N0113A

Hordenine sulfate Ordenina sulfate; Peyocactine sulfate	Antibiotic	Others
Hordenine sulfate (Ordenina sulfate) is an active compound extracted from malted barley that has melanin-inhibiting activity. Hordenine sulfate significantly reduced melanin content and reduced intracellular cAMP levels. Hordenine sulfate inhibits the expression of proteins related to melanogenesis, including microblind transcription factor (MITF), tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2. Therefore, Hordenine sulfate can be used as an active ingredient to inhibit pigmentation .

HY-N3773

Dodoviscin A	Tyrosinase	Cancer
Dodoviscin A is a pigmentation-altering agent, which can be isolated from the aerial parts of Dodonaea viscosa. Dodoviscin A inhibits melanin production in B16-F10 melanoma cells. Dodoviscin A suppresses mushroom tyrosinase activity, and tyrosinase activity induced by 3-isobutyl-1-methylxanthine. Dodoviscin A also inhibits the phorphosylation of cAMP response element binding protein, induced by 3-isobutyl-1-methylxanthine and forskolin .

HY-W750672

Astaxanthin dipalmitate	Drug Derivative	Others
Astaxanthin dipalmitate is a carotenoid. Astaxanthin dipalmitate can be used for pigmentation of rainbow trout and sea trout. Carotenoids are important biological active, and may regulate cellular differentiation, growth control, photooxidative protection, cell membrane stability, photosynthesis, vision process and nutrition .

HY-179100

Tyrosinase-IN-45	Tyrosinase	Inflammation/Immunology
Tyrosinase-IN-45 (compound 4) is a tyrosinase inhibitor (IC₅₀ = 1.51 μM). Tyrosinase-IN-45 can reduce the melanin content. Tyrosinase-IN-45 can be used for skin whitening and improving pigmentation .

HY-N10337

Norjuziphine (-)-Norjuziphine	Drug Derivative	Cancer
Norjuziphine ((-)-Norjuziphine) is an alkaloid found in the lotus flower (Nelumbo nucifera). Norjuziphine inhibits the melanogenesis of murine B16 melanoma 4A5 cells stimulated by Theophylline (HY-B0809) (IC₅₀=14.4 μM). Norjuziphine is promising for research of skin whitening and related skin pigmentation diseases .

HY-179619

Tyrosinase-IN-46	Tyrosinase	Metabolic Disease
Tyrosinase-IN-46 (Compound III19) is a tyrosinase inhibitor. Its IC₅₀ values for L-dopa and L-tyrosine are 3.24 and 2.79 nM respectively. Tyrosinase-IN-46 inhibits melanin synthesis and shows a significant anti-pigmentation effect. Tyrosinase-IN-46 can be used for the study of pigmentation disorders .

HY-N9846

Luteolin 5,3'-dimethyl ether	Cholinesterase (ChE) Glycosidase	Neurological Disease Metabolic Disease
Luteolin 5,3'-dimethyl ether is a flavonoid compound that exhibits strong binding to enzymes such as acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and α-Glycosidase. Luteolin 5,3'-dimethyl ether can be naturally extracted from the dried roots of Alhagi maurorum (camel thorn). The methanol extract of this plant has significant free radical scavenging ability and enzyme inhibitory potential. Luteolin 5,3'-dimethyl ether can be used in research related to neurodegenerative diseases, diabetes, and skin pigmentation-related diseases .

Acid Black 2 Nigrosine	Fluorescent Dye
Acid Black 2 (Nigrosine) is an alcohol-soluble absorber used to mimic skin pigmentation in tissue-mimicking phantoms. Acid Black 2 acts as an absorber in silicone-based thin tissue phantoms to simulate varying melanosome volume fractions in skin .

Cat. No.	Product Name	Type