2. Swertiajaponin

Swertiajaponin is a tyrosinase inhibitor, forms multiple hydrogen bonds and hydrophobic interactions with the binding pocket of tyrosinase, with an IC50 of 43.47 μM. Swertiajaponin also inhibits oxidative stress-mediated MAPK/MITF signaling, leading to decrease in tyrosinase protein level. Swertiajaponin suppresses melanin accumulation and exhibits strong anti-oxidative activity.

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Swertiajaponin Chemical Structure

Swertiajaponin Chemical Structure

CAS No. : 6980-25-2

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5 mg USD 210 In-stock
10 mg USD 340 In-stock
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Description

Swertiajaponin is a tyrosinase inhibitor, forms multiple hydrogen bonds and hydrophobic interactions with the binding pocket of tyrosinase, with an IC50 of 43.47 μM. Swertiajaponin also inhibits oxidative stress-mediated MAPK/MITF signaling, leading to decrease in tyrosinase protein level. Swertiajaponin suppresses melanin accumulation and exhibits strong anti-oxidative activity[1].

IC50 & Target

IC50: 43.47 μM (tyrosinase)[1]
Molecular Weight

462.40

Formula

C22H22O11
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C=C(C2=CC=C(O)C(O)=C2)OC3=CC(OC)=C([C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)C(O)=C13
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (540.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1626 mL 10.8131 mL 21.6263 mL
5 mM 0.4325 mL 2.1626 mL 4.3253 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.84%

COA (250 KB) HNMR (316 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1626 mL 10.8131 mL 21.6263 mL 54.0657 mL
5 mM 0.4325 mL 2.1626 mL 4.3253 mL 10.8131 mL
10 mM 0.2163 mL 1.0813 mL 2.1626 mL 5.4066 mL
15 mM 0.1442 mL 0.7209 mL 1.4418 mL 3.6044 mL
20 mM 0.1081 mL 0.5407 mL 1.0813 mL 2.7033 mL
25 mM 0.0865 mL 0.4325 mL 0.8651 mL 2.1626 mL
30 mM 0.0721 mL 0.3604 mL 0.7209 mL 1.8022 mL
40 mM 0.0541 mL 0.2703 mL 0.5407 mL 1.3516 mL
50 mM 0.0433 mL 0.2163 mL 0.4325 mL 1.0813 mL
60 mM 0.0360 mL 0.1802 mL 0.3604 mL 0.9011 mL
80 mM 0.0270 mL 0.1352 mL 0.2703 mL 0.6758 mL
100 mM 0.0216 mL 0.1081 mL 0.2163 mL 0.5407 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Swertiajaponin6980-25-2Inhibitorinhibitorinhibit

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