42369-86-8
Chemical Structure
N,N′-Diferuloylputrescine
Synonym(s): (E/Z)-Terrestribisamide
- CAS No.: 42369-86-8
- Formula:C24H28N2O6
- Molecular Weight:440.49
InChIKey: CHEMZHJQHCVLFI-MKICQXMISA-N
SMILES: O=C(NCCCCNC(/C=C/C1=CC=C(C(OC)=C1)O)=O)/C=C/C2=CC=C(C(OC)=C2)O
Biological Activity: N,N′-Diferuloylputrescine ((E/Z)-Terrestribisamide) is an inhibitor of pigmentation that reduces pigmentation in vivo. N,N′-Diferuloylputrescine exhibits anti-melanogenic, antioxidant, and α-glucosidase (α-glucosidase) inhibitory activities. N,N′-Diferuloylputrescine significantly decreases MITF protein levels and scavenges reactive oxygen species, while protecting neuroblastoma cells, keratinocytes, and erythrocytes from oxidative damage. N,N′-Diferuloylputrescine can be used for research on pigmentation, non-insulin-dependent diabetes mellitus, neurodegenerative diseases, and skin aging[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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N,N′-Diferuloylputrescine | 97.0% | N,N′-Diferuloylputrescine ((E/Z)-Terrestribisamide) is an inhibitor of pigmentation that reduces pigmentation in vivo. N,N′-Diferuloylputrescine exhibits anti-melanogenic, antioxidant, and α-glucosidase (α-glucosidase) inhibitory activities. N,N′-Diferuloylputrescine significantly decreases MITF protein levels and scavenges reactive oxygen species, while protecting neuroblastoma cells, keratinocytes, and erythrocytes from oxidative damage. N,N′-Diferuloylputrescine can be used for research on pigmentation, non-insulin-dependent diabetes mellitus, neurodegenerative diseases, and skin aging. | ||||||||||||||||||||
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References
- [1]. Kim MJ, et al. Effect of hydroxycinnamic acid derivatives from corn bran on melanogenic protein expression. Journal of the Korean Society for Applied Biological Chemistry. 2010 Aug;53(4):422-6.
- [2]. Niwa T, et al. Inhibitory activity of corn-derived bisamide compounds against alpha-glucosidase. Journal of agricultural and food chemistry. 2003 Jan 01;51(1):90-4.
- [3]. Xin XL, et al. Phenylpropanoid amides from Alisma orientalis and their protective effects against H2O2-induced damage in SH-SY5Y cells. Phytochemistry Letters. 2017 Sep 1;21:46-50.
- [4]. Taj R, Sorensen J L. Synthesis of Actinomycetes natural products JBIR-94, JBIR-125, and related analogues[J]. Tetrahedron Letters, 2015, 56(51): 7108-7111.
- [5]. Hwang J P, Ha J H, No G Y, et al. Cellular protective effect of novel dimeric ferulamide derivatives against UVA and 1O2 and its structural mechanism[J]. Journal of industrial and engineering chemistry, 2017, 53: 164-170.
