136 Results for "

protease substrate

" in MedChemExpress (MCE) Product Catalog:
Products (136)

136 Results for "protease substrate" in MCE Product Catalog:

13
13 Cited Publications
Cat. No.: HY-17367
CAS No.: 198904-31-3
Synonyms: BMS-232632
Atazanavir (BMS-232632) is a highly selective and orally active HIV-1 protease inhibitor . Atazanavir is a substrate and inhibitor of CYP3A4, and an inhibitor of P-glycoprotein (P-gp). Atazanavir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 3.49 μM. Atazanavir inhibits cardiac fibrosis, hyperlipidemia and induces malignant glioma death .
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13
13 Cited Publications
Cat. No.: HY-17367A
CAS No.: 229975-97-7
Synonyms: BMS-232632 sulfate
Atazanavir (BMS-232632) sulfate is a highly selective and orally active HIV-1 protease inhibitor with blood-brain barrier permeability. Atazanavir sulfate is a substrate and inhibitor of CYP3A4, and an inhibitor of P-glycoprotein (P-gp). Atazanavir sulfate is also a SARS-CoV 3CL pro inhibitor with an IC50 of 3.49 μM. Atazanavir sulfate inhibits cardiac fibrosis, hyperlipidemia and induces malignant glioma death .
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3
3 Cited Publications
Cat. No.: HY-D1080
CAS No.: 50402-56-7
Synonyms: 1,5-EDANS
EDANS (1,5-EDANS) is a novel and quenched fluorogenic substrate for assaying retroviral protease by resonance energy transfer (RET) .
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3
3 Cited Publications
Cat. No.: HY-P2295
Target:  

SARS-CoV

Research Areas:  

Others

Dabcyl-KTSAVLQSGFRKME-Edans TFA is a fluorogenic peptide. Dabcyl-KTSAVLQSGFRKME-Edans TFA is used as the substrate to measure the enzymatic activities of protease forms. Dabcyl-KTSAVLQSGFRKME-Edans TFA has the potential for study 2019-nCoV (COVID-19) infection .
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2
2 Cited Publications
Cat. No.: HY-N1181
CAS No.: 603-61-2
Synonyms: 4'-O-Methyl Quercetin
Tamarixetin (4'-O-Methyl Quercetin) is an orally active natural flavonoid derivative of quercetin and caseinolytic protease p (ClpP) inhibitor with anti-inflammatory, antioxidant and antitumor effects. Tamarixetin inhibits the hydrolytic activity of ClpP to the fluorescent substrate Suc-LY-AMC with an IC50 of 49.73 μM, which can be used for the study of Staphylococcus aureus infection. Tamarixetin inhibits tumor cell growth, induces apoptosis, and cell cycle arrest. Tamarixetin prevents cardiac hypertrophy by inhibiting the NFAT and AKT pathways .
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2
2 Cited Publications
Cat. No.: HY-111832
CAS No.: 79886-50-3
Purity:  99.08%
Synonyms: TeGG
1,2,3,6-Tetragalloylglucose (TEgG) is a competitive inhibitor of UDP-glucuronyltransferase UGT1A1, targeting the competitive substrate binding site of UGT1A1. 1,2,3,6-Tetragalloylglucose inhibits UGT1A1-mediated β-estradiol 3-glucuronidation and SN-38 glucuronidation with IC50 of 6.01 μM and 4.31 μM, respectively, and binds to UGT1A1 with Ki of 3.55 μM. 1,2,3,6-Tetragalloylglucose also induces tumor cell apoptosis, inhibit cell proliferation, activates caspase-3 and induces DNA fragmentation in HL-60 cells. 1,2,3,6-Tetragalloylglucose also inhibits HIV integrase and reverse transcriptase, and inhibits HCV protease .
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1
1 Cited Publications
Cat. No.: HY-134435
CAS No.: 70375-22-3
Purity:  99.2%
Z-Arg-AMC hydrochloride is a fluorogenic substrate for trypsin and papain. Z-Arg-AMC hydrochloride can be used to research activity of trypsin (Ex/Em=355/460 nm) .
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1
1 Cited Publications
Cat. No.: HY-P4406
CAS No.: 100307-95-7
Target:  

Fluorescent Dye

Research Areas:  

Others

Abz-AGLA-Nba is a fluorogenic substrate for the determination of protease activity. Abz-AGLA-Nba is hydrolyzed to release aminoacyl benzimide (Abz-AGLA) and 2-naphthylaminoacyl (Nba). The product Abz-AGLA produced by this hydrolysis reaction is fluorescent under ultraviolet light and can emit a fluorescent signal .
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1
1 Cited Publications
Cat. No.: HY-B2228
CAS No.: 9001-92-7
Proteinase, Aspergillus oryzae is a serine protease that hydrolyzes peptide bonds in protein substrates, preferring alkaline conditions (optimal pH 10.5). It efficiently degrades casein, poly-L-glutamic acid, and poly-L-lysine, with activity irreversibly inhibited by diisopropylfluorophosphate (DFP) and potato inhibitor. This enzyme catalyzes proteolysis via serine residues in its active site, finding applications in food processing (e.g., soy sauce fermentation), detergents, and leather industries due to its high yield in solid-state fermentation and cost-effective production.
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1
1 Cited Publications
Cat. No.: HY-E70005H
CAS No.: 9001-12-1
Target:  

Proteasome

Research Areas:  

Cardiovascular Disease

Collagenase, Type VIII is a mixed enzyme derived from Clostridium histolyticum that contains collagenase, a nonspecific protease, and a clostripain. Collagenase, Type VIII can hydrolyze Type VIII collagen and may be used to study the formation of atherosclerosis. Type VIII collagen is a regulator of endothelial cell differentiation and angiogenesis, a substrate for cell adhesion and migration such as smooth muscle cells, and may accumulate in atherosclerosis. After endotoxin activates the expression of Collagenase, Type VIII, it can reduce the production of Type VIII collagen and has the potential to inhibit atherosclerosis .
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Cat. No.: HY-137784
CAS No.: 70375-24-5
Purity:  99.43%
Target:  

Fluorescent Dye

Research Areas:  

Others

Boc-Val-Pro-Arg-AMC hydrochloride is a sensitive fluorogenic substrate for measuring trypsin-like serine proteases activity .
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Cat. No.: HY-P4326
CAS No.: 65147-04-8
Target:  

Fluorescent Dye

Research Areas:  

Others

Boc-Val-Pro-Arg-MCA is a sensitive fluorogenic substrate for measuring trypsin-like serine proteases activity .
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Cat. No.: HY-131409
CAS No.: 62354-43-2
Purity:  99.55%
Synonyms: D-Val-Leu-Lys-p-itoailide dihydrochloride; D-VLK-pNA dihydrochloride; S 2251 dihydrochloride
Target:  

Fluorescent Dye

Research Areas:  

Others

D-Val-Leu-Lys-pNA (D-Val-Leu-Lys-p-nitroanilide) dihydrochloride is a chromogenic peptide substrate that serves as a characteristic substrate for plasmin and plasminogen. D-Val-Leu-Lys-pNA dihydrochloride acts as a sensitive substrate for the DFE27 serine protease derived from Bacillus subtilis DC27. Catalyzed by plasmin, D-Val-Leu-Lys-pNA dihydrochloride binds and hydrolyzes to release p-nitroaniline (pNA), which can be detected colorimetrically at 405 nm as a measure of fibrinolytic activity .
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Cat. No.: HY-W027544
CAS No.: 62935-72-2
Synonyms: 7-Methoxycoumarin-4-acetic acid
MCA (7-Methoxycoumarin-4-acetic acid) is a Coumarin (HY-N0709) derivative. MCA quantitates platelet-activating factor (PAF) by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities .
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Cat. No.: HY-P3949
CAS No.: 143147-75-5
Target:  

Fluorescent Dye

Research Areas:  

Others

Fluorescent Substrate for Glu-Specific Proteases is a V8 protease-Specific chromogenic substrate .
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Cat. No.: HY-148073
Research Areas:  

Others

MeO-Succ-Arg-Pro-Tyr-AMC TFA is a fluorogenic peptide substrate for chymotrypsin-like proteases that detects protease activity . (measured at 460 nm)
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Cat. No.: HY-137840
CAS No.: 744-59-2
Purity:  98.21%
Hippuryl-L-phenylalanine is a substrate of carboxypeptidase. Carboxypeptidase is a protease enzyme that related with obesity, epilepsy and neurodegeneration. Hippuryl-L-phenylalanine can be used for the determination of carboxypeptidase activity .
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Cat. No.: HY-P4425
CAS No.: 201852-70-2
Research Areas:  

Others

Gly-Phe-AMC is a fluorogenic peptide substrate consisting of a peptide sequence composed of glycine and phenylalanine, linked to the fluorophore AMC. Gly-Phe-AMC also serves as a cathepsin C substrate. Gly-Phe-AMC is widely used to detect the activity of various proteases .
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Cat. No.: HY-P2065
CAS No.: 219137-97-0
Target:  

Fluorescent Dye

Research Areas:  

Others

Ac-VEID-AMC is a fluorescent substrate for the determination of caspase-6 and related cysteine protease activities (Ex=340-360 nm, Em=440-460 nm) .
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Cat. No.: HY-P2990
CAS No.: 9014-74-8
Synonyms: TMPRSS15
Target:  

Ser/Thr Protease

Research Areas:  

Metabolic Disease

Enteropeptidase (TMPRSS15), a type II transmembrane serine protease and a physiological activator of trypsinogen. Enteropeptidase is associated with the brush border membrane (BBM) of the enterocytes in the upper small intestine. Trypsinogen is the primary substrate for Enteropeptidase. Enteropeptidase is involved in digestion in humans and animals .
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