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Pathways Recommended: Metabolic Enzyme/Protease
Results for "

protease substrate

" in MedChemExpress (MCE) Product Catalog:

120

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11

Fluorescent Dye

4

Biochemical Assay Reagents

81

Peptides

8

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5

Isotope-Labeled Compounds

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-137784
    Boc-Val-Pro-Arg-AMC hydrochloride

    		Fluorescent Dye Others
    Boc-Val-Pro-Arg-AMC hydrochloride is a sensitive fluorogenic substrate for measuring trypsin-like serine proteases activity .
    Boc-Val-Pro-Arg-AMC hydrochloride
  • HY-D1080
    EDANS
    3 Publications Verification

    1,5-EDANS

    		 Fluorescent Dye Others
    EDANS (1,5-EDANS) is a novel and quenched fluorogenic substrate for assaying retroviral protease by resonance energy transfer (RET) .
    EDANS
  • HY-P2295
    Dabcyl-KTSAVLQSGFRKME-Edans TFA
    2 Publications Verification

    		 SARS-CoV Others
    Dabcyl-KTSAVLQSGFRKME-Edans TFA is a fluorogenic peptide. Dabcyl-KTSAVLQSGFRKME-Edans TFA is used as the substrate to measure the enzymatic activities of protease forms. Dabcyl-KTSAVLQSGFRKME-Edans TFA has the potential for study 2019-nCoV (COVID-19) infection .
    Dabcyl-KTSAVLQSGFRKME-Edans TFA
  • HY-P4326
    Boc-Val-Pro-Arg-AMC

    		Fluorescent Dye Others
    Boc-Val-Pro-Arg-MCA is a sensitive fluorogenic substrate for measuring trypsin-like serine proteases activity .
    Boc-Val-Pro-Arg-AMC
  • HY-131409
    D-Val-Leu-Lys-pNA dihydrochloride

    D-Val-Leu-Lys-p-itoailide dihydrochloride; D-VLK-pNA dihydrochloride; S 2251 dihydrochloride

    		 Fluorescent Dye Others
    D-Val-Leu-Lys-pNA (D-Val-Leu-Lys-p-nitroanilide) dihydrochloride is a chromogenic peptide substrate that serves as a characteristic substrate for plasmin and plasminogen. D-Val-Leu-Lys-pNA dihydrochloride acts as a sensitive substrate for the DFE27 serine protease derived from Bacillus subtilis DC27. Catalyzed by plasmin, D-Val-Leu-Lys-pNA dihydrochloride binds and hydrolyzes to release p-nitroaniline (pNA), which can be detected colorimetrically at 405 nm as a measure of fibrinolytic activity .
    D-Val-Leu-Lys-pNA dihydrochloride
  • HY-W027544
    MCA

    7-Methoxycoumarin-4-acetic acid

    		 Fluorescent Dye Others
    MCA (7-Methoxycoumarin-4-acetic acid) is a Coumarin (HY-N0709) derivative. MCA quantitates platelet-activating factor (PAF) by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities .
    MCA
  • HY-142021
    Z-Leu-Arg-AMC

    		Cathepsin Parasite Infection Inflammation/Immunology
    Z-Leu-Arg-AMC is a fluorogenic peptide substrate for cysteine proteases (e.g., Cathepsin) (Ex=350 nm，Em=460 nm). Z-Leu-Arg-AMC is preferentially cleaved by Cathepsin K and S under weakly acidic conditions, while its hydrolysis relies on residual Cathepsin S activity at neutral pH. Z-Leu-Arg-AMC serves as a substrate for recombinant Sphenophorus levis Cathepsin L, falcipain-2, falcipain-3, berghepain-2, knowlepain-2, vivapain-2, as well as falcipain-2 chimeras and constructs. It enables quantitative detection of cysteine protease activity in human inflammatory bronchoalveolar lavage fluid via fluorescence generation. Z-Leu-Arg-AMC can be used in research related to pulmonary inflammatory diseases and malaria .
    Z-Leu-Arg-AMC
  • HY-P2895
    Clostripain

    Clostridiopeptidase B

    		 Endogenous Metabolite Others
    Clostripain (Clostridiopeptidase B) is a thiol protease isolated from Clostridium histolyticum. Clostripain exhibits proteolytic activity as well as amidase-esterase activity. The specificity of Clostripain is primarily restricted to arginine residues, but it also shows minor hydrolytic activity toward most lysine-containing substrates. Clostripain catalyzes the ammonolysis of Carbobenzoxyarginyl methyl ester to generate various dipeptides .
    Clostripain
  • HY-P3949
    Fluorescent Substrate for Glu-Specific Proteases

    		Fluorescent Dye Others
    Fluorescent Substrate for Glu-Specific Proteases is a V8 protease-Specific chromogenic substrate .
    Fluorescent Substrate for Glu-Specific Proteases
  • HY-148073
    MeO-Succ-Arg-Pro-Tyr-AMC TFA

    		Fluorescent Dye Ser/Thr Protease Others
    MeO-Succ-Arg-Pro-Tyr-AMC TFA is a fluorogenic peptide substrate for chymotrypsin-like proteases that detects protease activity . (measured at 460 nm)
    MeO-Succ-Arg-Pro-Tyr-AMC TFA
  • HY-137840
    Hippuryl-L-phenylalanine

    		Carboxypeptidase Cancer
    Hippuryl-L-phenylalanine is a substrate of carboxypeptidase. Carboxypeptidase is a protease enzyme that related with obesity, epilepsy and neurodegeneration. Hippuryl-L-phenylalanine can be used for the determination of carboxypeptidase activity .
    Hippuryl-L-phenylalanine
  • HY-P4425
    Gly-Phe-AMC

    		Biochemical Assay Reagents Others
    Gly-Phe-AMC is a fluorogenic peptide substrate consisting of a peptide sequence composed of glycine and phenylalanine, linked to the fluorophore AMC. Gly-Phe-AMC also serves as a cathepsin C substrate. Gly-Phe-AMC is widely used to detect the activity of various proteases .
    Gly-Phe-AMC
  • HY-P2065
    Ac-VEID-AMC

    		Fluorescent Dye Others
    Ac-VEID-AMC is a fluorescent substrate for the determination of caspase-6 and related cysteine protease activities (Ex=340-360 nm, Em=440-460 nm) .
    Ac-VEID-AMC
  • HY-134435
    Z-Arg-AMC hydrochloride
    1 Publications Verification

    		 Fluorescent Dye Others
    Z-Arg-AMC hydrochloride is a fluorogenic substrate for trypsin and papain. Z-Arg-AMC hydrochloride can be used to research activity of trypsin (Ex/Em=355/460 nm) .
    Z-Arg-AMC hydrochloride
  • HY-P2990
    Enteropeptidase

    TMPRSS15

    		 Ser/Thr Protease Metabolic Disease
    Enteropeptidase (TMPRSS15), a type II transmembrane serine protease and a physiological activator of trypsinogen. Enteropeptidase is associated with the brush border membrane (BBM) of the enterocytes in the upper small intestine. Trypsinogen is the primary substrate for Enteropeptidase. Enteropeptidase is involved in digestion in humans and animals .
    Enteropeptidase
  • HY-P4417
    Ac-IEPD-AMC

    		Fluorescent Dye Others
    Ac-IEPD-AMC is a fluorogenic substrate for the determination of protease activity. Ac-IEPD-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
    Ac-IEPD-AMC
  • HY-P4419A
    Boc-Asp(OBzl)-Pro-Arg-AMC acetate

    		Fluorescent Dye Others
    Boc-Asp(OBzl)-Pro-Arg-AMC acetate is a fluorogenic substrate for the determination of protease activity. Boc-Asp(OBzl)-Pro-Arg-AMC acetate undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
    Boc-Asp(OBzl)-Pro-Arg-AMC acetate
  • HY-137303
    FA-Gly-Leu-NH2

    FAGLA

    		 Bacterial Others
    FA-Gly-Leu-NH2 (FAGLA) is a dipeptide substrate for proteases that can be hydrolyzed by thermophilic proteases and neutral proteases, showing pH-dependent variations in kcat/Km .
    FA-Gly-Leu-NH2
  • HY-P3934
    HIV Protease Substrate I

    		HIV Protease Infection
    HIV Protease Substrate I is a chromogenic substrate of HIV-1 protease. HIV Protease Substrate I has the cleavage site of HIV protease .
    HIV Protease Substrate I
  • HY-D1685
    BZiPAR

    		Fluorescent Dye Others
    BZiPAR is a fluorescent probe. BZiPAR also is a substrate of trypsin that becomes fluorescent after cleavage by the protease .
    BZiPAR
  • HY-129867
    Z-Leu-Leu-Leu-AMC

    Z-LLL-AMC

    		 Proteasome Others
    Z-Leu-Leu-Leu-AMC is a fluorogenic substrate for measuring the chymotrypsin-like protease activity of the 20S proteasome .
    Z-Leu-Leu-Leu-AMC
  • HY-P3794
    Glu-Ala-Leu-Phe-Gln-pNA

    		Virus Protease Infection
    Glu-Ala-Leu-Phe-Gln-pNA is a Chiba virus 3C-like protease (CVP) substrate .
    Glu-Ala-Leu-Phe-Gln-pNA
  • HY-P5313A
    Abz-Nle-Lys-Arg-Arg-Ser-3-(NO2)Tyr acetate

    		Dengue Virus Infection
    Abz-Nle-Lys-Arg-Arg-Ser-3-(NO2)Tyr acetate is a DEN protease substrate, which can be used in research related to dengue virus (drug development) .
    Abz-Nle-Lys-Arg-Arg-Ser-3-(NO2)Tyr acetate
  • HY-P4406
    Abz-AGLA-Nba
    1 Publications Verification

    		 Fluorescent Dye Others
    Abz-AGLA-Nba is a fluorogenic substrate for the determination of protease activity. Abz-AGLA-Nba is hydrolyzed to release aminoacyl benzimide (Abz-AGLA) and 2-naphthylaminoacyl (Nba). The product Abz-AGLA produced by this hydrolysis reaction is fluorescent under ultraviolet light and can emit a fluorescent signal .
    Abz-AGLA-Nba
  • HY-D1080R
    EDANS (Standard)

    1,5-EDANS (Standard)

    		 Fluorescent Dye Reference Standards Others
    EDANS (1,5-EDANS) (Standard) is an analytical standard for EDANS. This product is intended for research and analytical applications. EDANS (1,5-EDANS) is a novel quenched fluorogenic substrate for the analysis of retroviral proteases by resonance energy transfer .
    EDANS (Standard)
  • HY-158307
    Z-Arg-Arg-βNA acetate

    		Cathepsin Others
    Z-Arg-Arg-βNA acetate is a sensitive dipeptide substrate of the protease Cathepsin B and resistant to proteases H and L. Z-Arg-Arg-βNA acetate can serve as an important tool for distinguishing non-Cathepsin B type proteins .
    Z-Arg-Arg-βNA acetate
  • HY-137872
    L-Leucyl-4-nitroanilide hydrochloride

    		Biochemical Assay Reagents Others
    L-Leucyl-4-nitroanilide hydrochloride is a commonly used substrate in various biochemical assays to measure the activity of enzymes that cleave peptide bonds, such as proteases. L-Leucine p-nitroanilide hydrochloride has unique chemical properties that allow it to be cleaved by these enzymes to form a yellow product called p-nitroaniline. This makes it a useful tool for detecting and quantifying protease activity in biological samples such as blood or tissue extracts.
    L-Leucyl-4-nitroanilide hydrochloride
  • HY-P5062A
    DEC-RVRK-CMK TFA

    Decanoyl-Arg-Val-Arg-Lys-chloromethylketone TFA

    		 Furin Infection
    DEC-RVRK-CMK (Decanoyl-Arg-Val-Arg-Lys-chloromethylketone) TFA is a peptide-based CMK (chloromethylketone) inhibitor that targets and inactivates the secreted soluble kexin (Kex2) (Ki=8.45 μM). The yeast enzyme Kex2 (kexin, EC 3.4.21.61) is a calcium-dependent transmembrane protease and belongs to the mammalian protease family of the serine protease subtilisin family. The binding mechanism of Kex2 with different CMK inhibitors depends on substrate selectivity, particularly the selective differences between lysine and arginine at the P1 position .
    DEC-RVRK-CMK TFA
  • HY-134113
    Z-Gly-Pro-Arg-pNA

    CBZ-Chromozym TH

    		 Biochemical Assay Reagents Others
    Z-Gly-Pro-Arg-pNA (z-GPR-pNA) is a photometric substrate in Prostate-Specific Antigen (PSA) activation protease assays. Z-Gly-Pro-Arg-pNA (z-GPR-pNA) can be used for the test of trypsin activity .
    Z-Gly-Pro-Arg-pNA
  • HY-171444
    GSM III

    		γ-secretase Amyloid-β Neurological Disease
    GSM III is a γ-Secretase complexe (GSEC) modulator. GSM III significantly regulates amyloid-β (Aβ) length at the extracellular interface between the protease (NCT, PSEN) and the substrate APPC99. GSM III can be used for Alzheimer's disease (AD) research .
    GSM III
  • HY-P4417A
    Ac-IEPD-AMC TFA

    		Fluorescent Dye Others
    Ac-IEPD-AMC TFA is a fluorescent substrate used to measure protease activity. Ac-IEPD-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC fluoresces under UV light irradiation and can emit fluorescent signals .
    Ac-IEPD-AMC TFA
  • HY-P4323A
    Boc-Gln-Arg-Arg-AMC acetate

    		Fluorescent Dye Others
    Boc-Gln-Arg-Arg-AMC acetate is a fluorogenic substrate for the determination of protease activity. Boc-Gln-Arg-Arg-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). AMC is fluorescent under UV light and can emit a fluorescent signal .
    Boc-Gln-Arg-Arg-AMC acetate
  • HY-D1079
    EDANS sodium

    		DNA Stain Others
    EDANS sodium is a potent fluorogenic substrates. EDANS sodium is a donor for FRET-based nucleic acid probes and protease substrates. EDANS sodium is often paired with DABCYL or DABSYL. The optimal absorbance and emission wavelengths of EDANS sodium are λabs = 336 nm and λem = 490 nm respectively .
    EDANS sodium
  • HY-P3948
    Fluorescent Substrate for Pro-Specific Proteases

    		Fluorescent Dye Others
    Fluorescent Substrate for Pro-Specific Proteases is a fluorescent substrate of pro-specific proteases. Fluorescent Substrate for Pro-Specific Proteases can be used to detect the hydrolysis rate and activity of target enzyme .
    Fluorescent Substrate for Pro-Specific Proteases
  • HY-136143
    (BHQ-3)-OSu hexafluorophosphate

    		Fluorescent Dye Others
    (BHQ-3)-OSu hexafluorophosphate is used for fluorescent labeling of protease substrates .
    (BHQ-3)-OSu hexafluorophosphate
  • HY-P4496
    Tos-Gly-Pro-Lys-pNA

    		Phosphatase Others
    Tos-Gly-Pro-Lys-pNA is a substrate for the serine protease ALP and can be used to measure the activity of this enzyme .
    Tos-Gly-Pro-Lys-pNA
  • HY-P3947
    Fluorescent Substrate for Subtillsin

    		Ser/Thr Protease Infection
    Fluorescent Substrate for Subtillsin can be used to detect the enzyme activity of subtillsin. Subtilisin is a bacterial serine protease .
    Fluorescent Substrate for Subtillsin
  • HY-P4658
    H-Val-Ala-pNA

    		Dipeptidyl Peptidase Others
    H-Val-Ala-pNA is a substrate for the dipeptide aminopeptidase (DPAPase) of Streptococcus bovis. H-Val-Ala-pNA can be used to measure the activity of the protease .
    H-Val-Ala-pNA
  • HY-P11302
    DABCYL-RAGGYIFS-(E-EDANS)-NH2

    		CHIKV Virus Protease Infection
    DABCYL-RAGGYIFS-(E-EDANS)-NH2, an octapeptide, is a FRET-based substrate peptide of CHIKV nsP2protease with highly sensitivity. DABCYL-RAGGYIFS-(E-EDANS)-NH2 can be cleaved by the active CHIKV nsP2protease, separating fluorophore and quencher and resulting in an increase of fluorescence signal. DABCYL-RAGGYIFS-(E-EDANS)-NH2 can used for the determination of CHIKV nsP2protease activity .
    DABCYL-RAGGYIFS-(E-EDANS)-NH2
  • HY-P4580
    Suc-Ala-Ala-Pro-Phe-SBzl

    		Proteasome Others
    Suc-Ala-Ala-Pro-Phe-SBzl can be used as the substrate of rat intestinal mast cell protease (RMCP I), rat skeletal muscle mast cell protease (RMCP II) and Chymotrypsin (HY-108910). Suc-Ala-Ala-Pro-Phe-SBzl can be hydrolyzed by glycine (R208G) .
    Suc-Ala-Ala-Pro-Phe-SBzl
  • HY-P4039
    Ac-EEVVAC-pNA

    		HCV Protease Infection
    Ac-EEVVAC-pNA is a chromogenic substrate for a continuous spectrophotometric assay of HCV NS3 protease. The sequence EEVVAC is derived from the 5A-5B cleavage junction of the HCV polyprotein .
    Ac-EEVVAC-pNA
  • HY-P3980
    HIV-1, HIV-2 Protease Substrate

    		HIV Protease Infection
    HIV-1, HIV-2 Protease Substrate is the substrate of HIV-1, HIV-2 protease. And there are 4 residues for conservative substitutions of the substrate binding residues of HIV-1 and HIV-2 protease .
    HIV-1, HIV-2 Protease Substrate
  • HY-P5062
    DEC-RVRK-CMK

    Decanoyl-Arg-Val-Arg-Lys-chloromethylketone

    		 Furin Infection
    DEC-RVRK-CMK (Decanoyl-Arg-Val-Arg-Lys-chloromethylketone) is a peptide-based CMK (chloromethylketone) inhibitor that targets and inactivates the secreted soluble kexin (Kex2) (Ki=8.45 μM). The yeast enzyme Kex2 (kexin, EC 3.4.21.61) is a calcium-dependent transmembrane protease and belongs to the mammalian protease family of the serine protease subtilisin family. The binding mechanism of Kex2 with different CMK inhibitors depends on substrate selectivity, particularly the selective differences between lysine and arginine at the P1 position .
    DEC-RVRK-CMK
  • HY-17367S4
    Atazanavir-d6

    BMS-232632-d6

    		 Isotope-Labeled Compounds HIV HIV Protease SARS-CoV Cytochrome P450 P-glycoprotein Endogenous Metabolite Infection Cancer
    Atazanavir-d6 is deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration . Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp) . Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM .
    Atazanavir-d6
  • HY-P4406A
    Abz-AGLA-Nba TFA

    		Fluorescent Dye Others
    Abz-AGLA-Nba TFA is a fluorogenic substrate for the determination of protease activity. Abz-AGLA-Nba TFA is hydrolyzed to release aminoacyl benzimide (Abz-AGLA) and 2-naphthylaminoacyl (Nba). The product Abz-AGLA produced by this hydrolysis reaction is fluorescent under ultraviolet light and can emit a fluorescent signal .
    Abz-AGLA-Nba TFA
  • HY-P4018
    HIV Protease Substrate IV

    		HIV Protease Infection
    HIV Protease Substrate IV is a substrate of HIV protease. HIV Protease Substrate IV can be used to measure the activity of HIV (human immunodeficiency virus) -1 protease .
    HIV Protease Substrate IV
  • HY-120659
    Gly-Gly-AMC

    		Fluorescent Dye Others
    Gly-Gly-AMC is a fluorogenic peptide substrate. Gly-Gly-AMC can be used to assess bacterial protease activity of P. aeruginosa and S. aureus .
    Gly-Gly-AMC
  • HY-W141825
    N-Acetyl-DL-phenylalanine β-naphthyl ester

    		Fluorescent Dye Infection Metabolic Disease
    N-Acetyl-DL-phenylalanine β-naphthyl ester is an aromatic amino acid ester, which functions as a chromogenic substrate for chymotrypsin and microbial serine proteases such as subtilisin .
    N-Acetyl-DL-phenylalanine β-naphthyl ester
  • HY-P2344
    HIV Protease Substrate 1

    		HIV Protease Infection
    HIV Protease Substrate 1, a fiuorogenic HIV protease substrate, can be used to study enzymatic activity of HIV protease .
    HIV Protease Substrate 1
  • HY-P4443
    Ac-GAK-AMC

    		Fluorescent Dye Others
    Ac-GAK-AMC is a fluorescent substrate that can be used to measure protease activity. AMC (7-amino-4-methylcoumarin) is a fluorescent group. In the presence of protease, the protease will hydrolyze Ac-GAK-AMC into a fluorescent product .
    Ac-GAK-AMC

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